[PDF] Top 20 Role of RNA Structures in Genome Terminal Sequences of the Hepatitis C Virus for Replication and Assembly
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Role of RNA Structures in Genome Terminal Sequences of the Hepatitis C Virus for Replication and Assembly
... in RNA replication, in con- trast to what is described for genotype 1b (18), arguing that either the requirements for RNA replication differ between ...) RNA and their impact on HCV ... See full document
7
The Acidic Domain of Hepatitis C Virus NS4A Contributes to RNA Replication and Virus Particle Assembly
... Hepatitis C virus NS3-4A is a membrane-bound enzyme complex that exhibits serine protease, RNA helicase, and RNA-stimulated ATPase ...viral genome replication and has been ... See full document
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Hepatitis C Virus RNA Replication and Virus Particle Assembly Require Specific Dimerization of the NS4A Protein Transmembrane Domain
... Hepatitis C virus (HCV) NS4A is a single-pass transmembrane (TM) protein essential for viral replication and particle ...in RNA replication and/or virus ...and ... See full document
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The C terminus of NS5A domain II is a key determinant of hepatitis C virus genome replication, but is not required for virion assembly and release.
... for genome replication, whereas D333 and Y334 (JFH-1 D329 and Y330) are not ...the C-terminal 30 residues of the NS5A domain II have no role in either the assembly or release of ... See full document
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Poly(C)-Binding Protein 2 Interacts with Sequences Required for Viral Replication in the Hepatitis C Virus (HCV) 5′ Untranslated Region and Directs HCV RNA Replication through Circularizing the Viral Genome
... HCV RNA and ...the RNA replication ...HCV RNA replication in vitro strongly suggests that PCBP2 is directly involved in HCV RNA ...the assembly of the replication ... See full document
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A Hepatitis C Virus cis-Acting Replication Element Forms a Long-Range RNA-RNA Interaction with Upstream RNA Sequences in NS5B
... functional role(s) of phylogenetically con- served RNA secondary structures in coding regions has been analyzed extensively by reverse genetic analysis, predominantly using antibiotic resistance or a ... See full document
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A Conserved Proline between Domains II and III of Hepatitis C Virus NS5A Influences both RNA Replication and Virus Assembly
... a role for NS5A in virus assembly (2, 20, ...infectious virus produced and the kinetics of virus ...in virus production at 24 and 48 ...infectious virus rather than a ... See full document
9
Cytosolic Phospholipase A2 Gamma Is Involved in Hepatitis C Virus Replication and Assembly
... single-stranded RNA viruses, hepatitis C virus (HCV) replicates its genome in a remodeled intra- cellular membranous structure known as the membranous web ...HCV replication, and ... See full document
13
3′ Nontranslated RNA Signals Required for Replication of Hepatitis C Virus RNA
... the terminal sequences of the genome so as to initiate de novo transcription from the 3⬘ terminal ...novo RNA synthesis at the 3⬘ terminus by preventing movement of the 3⬘ end of the ... See full document
12
Large hepatitis delta antigen in packaging and replication inhibition: role of the carboxyl-terminal 19 amino acids and amino-terminal sequences.
... delta virus (HDV) encodes two proteins, the small delta antigen (SHDAg) and large delta antigen ...the C terminus. While SHDAg is required for HDV replication, LHDAg inhibits replication and, ... See full document
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Specific Interaction of Hepatitis C Virus Protease/Helicase NS3 with the 3′-Terminal Sequences of Viral Positive- and Negative-Strand RNA
... stem-loop structures, SL-I, SL-II, and ...this role of NS4A (3, 4, 15, 33, 34, ...HCV RNA replication; however, various laboratories have recently demonstrated synthesis of full-length ... See full document
14
Casein kinase II and protein kinase C modulate hepatitis delta virus RNA replication but not empty viral particle assembly.
... of the mutated amino acid in the HDAg and the nature of the amino acids before and after the mutation (see below). Underlining indicates mutated bases. All mutant sequences were confirmed by sequencing. The ... See full document
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Kissing-Loop Interaction in the 3′ End of the Hepatitis C Virus Genome Essential for RNA Replication
... The hepatitis C virus (HCV) is the only member of the Hepacivirinae within the Flaviviridae family ...an RNA genome of positive polarity that in the case of HCV has a length of about ... See full document
13
cis-Acting RNA Signals in the NS5B C-Terminal Coding Sequence of the Hepatitis C Virus Genome
... cis-replicating RNA elements in the 5 ⴕ and 3 ⴕ nontranslated regions (NTRs) of the hepatitis C virus (HCV) genome have been thoroughly studied ...coding sequences of the HCV ... See full document
13
Hydrophobic and Charged Residues in the C-Terminal Arm of Hepatitis C Virus RNA-Dependent RNA Polymerase Regulate Initiation and Elongation
... The RNA-dependent RNA polymerase (RdRp) of hepatitis C virus (HCV) is essential for viral genome ...two C-terminal features, a -loop and a C-terminal ... See full document
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Dengue Virus- and Hepatitis C Virus-Induced Replication and Assembly Compartments: the Enemy Inside—Caught in the Web
... underlying RNA replication and virus production differ substan- ...strand RNA genome is delivered into the cytoplasm and used for RNA ...positive-strand RNA viruses, HCV ... See full document
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Sequences in the 5′ Nontranslated Region of Hepatitis C Virus Required for RNA Replication
... by sequences at the 3⬘ end of stem-loop ...BVDV replication in cell ...minus-strand RNA acts as the promoter for initiation of plus- strand RNA synthesis, this observation implies that the ... See full document
11
Genetic Analysis of Sequences in the 3′ Nontranslated Region of Hepatitis C Virus That Are Important for RNA Replication
... infectious genome is viable in vivo ...of RNA replication and whether the full complement of the vari- able region is dispensable for RNA replication, ...for RNA ... See full document
13
An N-Terminal Amphipathic Helix in Hepatitis C Virus (HCV) NS4B Mediates Membrane Association, Correct Localization of Replication Complex Proteins, and HCV RNA Replication
... the role of NS4B’s involvement in the formation of the HCV membrane struc- tures that presumably harbor the replication complex (15, 21), it is tempting to speculate that the AH domain may be involved in ... See full document
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Intragenic Complementation of Hepatitis C Virus NS5A RNA Replication-Defective Alleles
... for replication of the JFH1 ...with replication being facilitated by phosphorylation of these ...same replication-null phenotype as a replicon with an S229A substitution, indicating that introduction ... See full document
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