Top PDF A Study on Clinical and Biochemical Profile in Diabetic Ketoacidosis

A Study on Clinical and Biochemical Profile in Diabetic Ketoacidosis

A Study on Clinical and Biochemical Profile in Diabetic Ketoacidosis

Diabetes is a metabolic disorder of various etiology characterized by prolonged hyperglycemia with disturbances of carbohydrate, fat, and protein metabolism. It is due to defective insulin secretion, insulin action, or both. The long term complications of diabetes are retinopathy with blindness, nephropathy that may lead to renal failure, neuropathy with foot ulcers, limb amputation, Charcot joints, and autonomic dysfunction like postural hypotension, sexual dysfunction etc. The short term complications of diabetes mellitus are diabetic ketoacidosis and hyperosmolar hyperglycemic state (2). Both are life threatening complications in uncontrolled diabetes.
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Clinical and Biochemical Profile of Women Presenting with Hirsutism and It’s treatment Outcome: A Prospective study

Clinical and Biochemical Profile of Women Presenting with Hirsutism and It’s treatment Outcome: A Prospective study

This study evaluates the various causes of hirsutism, their clinical and biochemical profile and their outcome after treatment. Although PCOS is the most common cause for hirsutism, other causes should also be thought of. The treatment should be individualised depending upon the cause of hirsutism. We should have a high suspicion of virilizing tumours if features of virilization are present. Hirsutism has a response to OCP containing cyproterone acetate but the reduction in severity of hirsutism is mild. They might need increase in the duration of treatment and dosage of cyproterone acetate. Free testosterone and DHEAS may or may not be elevated in PCOS. Majority have normal levels. Free testosterone is highly elevated in androgen secreting ovarian tumours. This study has highlighted the importance of evaluating the other causes of hirsutism such as androgen secreting ovarian tumours and adrenal hyperplasia. Hirsutism causes cosmetic problem and psychological upset on a woman. It can also be a manifestation of an underlying health problem. Hence it should be properly treated so that a favourable outcome can be obtained.
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Study of clinical and biochemical profile of acute alcoholic liver disease in a teaching hospital in Telangana

Study of clinical and biochemical profile of acute alcoholic liver disease in a teaching hospital in Telangana

Background: Chronic alcohol consumption gives rise to various health risks that include liver disease, heart disease, pancreatitis, central nervous system disorders and certain forms of cancer. Alcoholic liver disease (ALD) is a spectrum of clinicopathological abnormalities, reflecting an acute or chronic inflammation of the liver parenchyma induced by alcohol use. It is associated with changes in various biochemical parameters and also various clinical manifestations in the patients. The objective of the present study to evaluate clinical and biochemical profile of acute alcoholic liver disease.
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Study of Clinical and Biochemical Profile in Neonatal Seizure in a tertiary care centre of Jharkhand

Study of Clinical and Biochemical Profile in Neonatal Seizure in a tertiary care centre of Jharkhand

Results: In my study, neonatal seizure occurred more commonly in term babies especially in appropriate for gestational age babies compared to preterm neonates. There was a male predominance. Most seizures are due to intramural deliveries and occurred within 72 hours of life. Seizures are more common in babies with birth weight ≥2.5 kg and subtle seizure is the most common type. The most common biochemical abnormality noted was hypoglycemia (40%) and hypocalcemia (32%). There were cases reported with combination of hypoglycemia / hypocalcemia and hypocalcemia/hypomagnesemia particularly in preterm but their incidence is low.
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A study of clinical and biochemical profile in neonatal seizures in a tertiary care centre

A study of clinical and biochemical profile in neonatal seizures in a tertiary care centre

Baseline characteristics of all the babies were noted on the prescribed proforma which includes name, age, sex, address weight, length, head circumference, gestational age, which is determined from mother by last menstrual period or ultrasound study of fetus before birth or by new Ballard scoring of the neonate. Thorough physical examination was done and seizures were diagnosed by clinical observation . Clinical details of each seizure episode were recorded like age at onset of seizures, duration of seizure, number and type of seizure. Seizure was classified into subtle, focal clonic, multifocal clonic, tonic, and myoclonic as per criteria by Volpe.
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Study of clinical and biochemical profile of subclinical hypothyroidism in children aged 2-12 years

Study of clinical and biochemical profile of subclinical hypothyroidism in children aged 2-12 years

Mean left ventricular wall thickness (IVS and LVPW) of study patients as obtained by M-mode measurements were significantly higher when compared to population mean. Statistically significant increase in Left Ventricular wall thickness in our study group was obtained as a one point measurement. Serial monitoring of these children will be needed to ascertain the clinical and hemodynamic significance of this finding. Left ventricular dimensions during both phases of cardiac cycle were within normal limits. Left ventricular systolic functions which were measured by afterload dependent parameters like Ejection fraction and Fractional shortening were also within normal range.
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To Study the Correlation Between Clinical and Biochemical Profile in Patients with Multinodular Goiter in Central India

To Study the Correlation Between Clinical and Biochemical Profile in Patients with Multinodular Goiter in Central India

Dysfunction of the thyroid gland leads to two sets of symptoms those related to the local effect of a mass in the neck and the effects of either an excess or a deficiency of thyroid hormones. Dysfunction of the thyroid gland ranks next only to diabetes mellitus amongst the endocrine diseases. Thyroid-stimulating hormone (TSH) presumably has an important role in the maintenance of thyroid growth and goitrogenesis. In this study a group of patients with multinodular goiter were examined clinically and investigated to find the various correlations.

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Comparison of clinical and biochemical profile of obese and nonobese children

Comparison of clinical and biochemical profile of obese and nonobese children

Even in city like Chennai awareness regarding childhood obesity was less and only 23% were aware of obesity and consequences hence came for medical attention while rest came for minor illness and were evaluated for obesity. We observed higher prevalence of obesity in upper socioeconomic group. A similar observation was made by a previous study done by Kotian et al where a higher prevalence of obesity was noted in higher socio- economic group. 11

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A Study on Clinical Spectrum, Biochemical and Hematological Profile of Acute Falliparum Malaria

A Study on Clinical Spectrum, Biochemical and Hematological Profile of Acute Falliparum Malaria

This study was a prospective clinical observational study done for a period of 12 months from June 2004to May 2005 Its objectives were to study the common clinical presentations and also atypical presentation if any of acute plasmodium falciparum malaria, to assess life threatening complications of severe malaria and to collect a detailed hematological and biochemical profile of acute falciparum malaria with objective of noting its abnormalities and correlation if any with clinical severity and prognosis.

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A study of predictors and factors affecting outcome in diabetic ketoacidosis patients

A study of predictors and factors affecting outcome in diabetic ketoacidosis patients

DKA presents with various clinical manifestations . One such manifestation is altered sensorium which occurred in 20% of the study population and was the commonest manifestation following vomiting which occured in 26% of DKA population studied. The initial GCS calculated significantly affected the outcome. The worst outcomes were documented in individuals with less than 8 score. The previous studies did not show constant association of outcome with GCS. In study by Otieno et al., 173 altered level of consciousness was a major

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Evaluation of Ward Management of Diabetic Ketoacidosis

Evaluation of Ward Management of Diabetic Ketoacidosis

patients with DKA comprised 0.4% of all hospital admissions, with 52.6% of these patients admitted to ICUs. This study identified patient factors that may lead to ICU admis- sion, including income, insurance provider, teaching status of the hos- pital, and hospital occupancy, rather than the clinical presentation of the patients. No difference was noted in duration of hospitalization or mor- tality between ICU and non-ICU management. Previous studies have

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CLINICAL AND BIOCHEMICAL PROFILE OF STEROID INDUCED DIABETES

CLINICAL AND BIOCHEMICAL PROFILE OF STEROID INDUCED DIABETES

Objective: To study the clinical and biochemical profile of patients who develop steroid-induced diabetes (SID) and its predisposing factors. Methods: Non-diabetic patients aged ≥18 years started on steroids were considered eligible for the study. In every case after detailed examination, fasting plasma glucose (FPG), post-prandial plasma glucose (PPG), glycated hemoglobin, fasting insulin were measured prior to starting steroids and was repeated in 1 st week (day 3/4) after starting steroid according to standard guidelines. FPG and PPG were repeated periodically during follow-up
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Prolonged diabetic ketoacidosis associated with canagliflozin

Prolonged diabetic ketoacidosis associated with canagliflozin

uncertain. A meta-analysis of randomised controlled clinical trials reported a negligible effect of the medications on the presence of DKA (4, 5). These patients would be carefully selected and monitored throughout the study and the risk may be higher outside of this environment. In the United States, a claims database of insured patients was analysed to assess the risk of DKA in comparison to prescription of a dipeptidyl peptidase-4 inhibitor (6). Over 50 000 patients were prescribed an SGLT-2 inhibitor. The

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Clinical Profile and Severity of Stroke in Diabetic and Non Diabetic Patients

Clinical Profile and Severity of Stroke in Diabetic and Non Diabetic Patients

Glucose insulin in ischemic stroke patients (GIST), stroke patients without past history of diabetes, had 21% diabetes, 37% of patients had IGT ,42% of patients had normal glucose values after 3 months of stroke 30 . According to a FINNISH study, diabetic patients have stroke mortality of 16% for men and stroke mortality of 33% for women. Nearly 50% of people with impaired glucose tolerance develop diabetes over the period of 10 years, but lifestyle changes like physical activity, diet, weight control can substantially reduce this progression. Early detection of diabetes and to control blood glucose and other risk factors are essential in stroke patient. Hyperglycemia during the acute phase of stroke worsens the outcome, probable mechanism is high lactate level in brain tissue reduces the salvage of the penumbral tissue.
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Clinical presentation and microorganisms sensitivity profile for diabetic foot ulcers: a pilot study

Clinical presentation and microorganisms sensitivity profile for diabetic foot ulcers: a pilot study

Wagner grade III and IV ulcers were the most common presentation of DFU. Gram negative microorganisms were commonly isolated. Proteus mirabilis was the common Gram negative microorganisms cultured. Staphylococcus aureus was the common Gram positive microorganism cultured. Contrary to the trends majority of patients had mono- microbial infection. Worryingly, MRSA were more frequently isolated as compared to the previous study from Malaysia. 13

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Clinical and metabolic profile of neonates of diabetic mothers

Clinical and metabolic profile of neonates of diabetic mothers

Weight of each baby was recorded and gestational age was calculated from New Ballard’s gestational scoring chart, subsequently they were grouped as Appropriate for Gestational Age (AGA), Large for Gestational Age (LGA) and Small for Gestational Age (SGA) by plotting their weight and gestational age on Lubchenco charts. All neonates underwent investigations like complete blood count, X-ray chest, metabolic profile including blood sugar, serum calcium, serum magnesium. Wherever indicated, serum bilirubin, ABG analysis & hematocrit was done on need basis. Blood sugar was done 6 hourly for 1 st 24 hours of life followed by 12 hourly upto 72 hours of life. Blood sugar was done by Glucostick method & any abnormal values if found were sent to laboratory for confirmation by glucose oxidase method. All the study neonates suspected of having congenital heart disease on clinical grounds or chest X- ray underwent transthoracic Doppler echocardiography. Hypoglycemia: It was defined as a blood glucose level <40 mg/dl in first 24 hours & <45 mg/dl after first 24 hours of life. 14
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An observational study of clinical profile of infants born to pregestational and gestational diabetic mothers

An observational study of clinical profile of infants born to pregestational and gestational diabetic mothers

abnormalities of growth, alterations in glucose and calcium levels, hematologic and cardiorespiratory problems and congenital anomalies. Diabetic mothers have a high incidence polyhydramnios, preeclampsia, pyelonephritis, preterm labour and chronic hypertension. Insulin has been the primary mode of therapy for diabetes complicating pregnancy for many decades. Some of the adverse effects of pregnancy can be prevented by preconception counselling, careful planning of mode and time of delivery, better glycaemic control, early screening for fetal abnormalities and good neonatal care. Recent advances in the management of women suffering from diabetes mellitus have decreased maternal and neonatal ABSTRACT
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Clinical Biochemical and Virological Profile of Hepatocellular Carcinoma

Clinical Biochemical and Virological Profile of Hepatocellular Carcinoma

Hereditary tyrosinemia has the clearest association with the development of HCC. Close to 40% of patients in one study developed HCC despite good dietary control. Tumors have also been reported in association with ataxia telangiectasia. Most other associations have not been borne out by more careful study, and convincing evidence of a genetic predisposition to the development of HCC is lacking. Familial clustering of HCC is seen in patients with chronic hepatitis B, but this is probably related to vertical and horizontal transmission of the hepatitis B. Differences between ethnic and geographic groups have been discussed above, and are probably more environmental than genetic. The association with Fanconi's anemia is probably related to the androgens used to treat the anemia rather than the underlying disease. Probably the best recognized and most striking association of a hereditary disease with the development of HCC is that with hereditary hemachromatosis. Hepatocellular carcinoma also may develop in patients with other inherited metabolic disorders that are complicated by cirrhosis, such as α 1 -antitrypsin deficiency and type 1
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Study comparing the clinical profile of patients with stroke in diabetic and non-diabetic patients

Study comparing the clinical profile of patients with stroke in diabetic and non-diabetic patients

Patients presenting with a typical history and a clinical examination which is suggestive of cerebrovascular accident above an age of 18 years are enrolled in our study and an immediate blood sample taken to estimate random blood sugar followed by a thorough clinical examination which classifies these patients into anyone of the seven Brunnstorm’s staging followed by an urgent non contrast CT scan of brains to confirm the diagnosis, to ascertain the type of stroke-ischemic or hemorrhagic to assess the size of the lesion as small, medium or large. Small-sized stroke in our study is taken as a lesion 5 mm in diameter which is not visible in more than two adjacent slices of the CT brain and on the contrary a large sized stroke is any lesion of size which is equal to or greater than 10 mm in diameter or involving one complete vascular territory, medium-size stroke is anything between small and large. These patients are followed up with conservative management and these patients are re- assessed at the time of discharge to classify the recovery at discharge in anyone of the seven Brunnstorm’s stages. 6
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The study of clinical, biochemical and hematological profile in malaria patients

The study of clinical, biochemical and hematological profile in malaria patients

In the present study 64.42% patients had anaemia. Severe anaemia i.e. hemoglobin less than 7gm/dl (as per who criteria) was observed in 34.61% of patients. Anemia in Malaria is multi factorial in origin. These factors include hemolysis of parasitized as well as non-parasitized cells, spleenic and reticular hyperactivity, genetic factors and oxidative stress and bone marrow suppression. 11,12 The nature of hematological abnormalities depends on the time after infection. A recent study has revealed a role of interleukins (IL–4) and interferon's (IFN–gamma) in erythropoietin suppression. 13,14 Inappropriately low reticulocytosis has been observed in malaria patients suggesting that insufficient erythropoiesis is major factor for anaemia.
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