[PDF] Top 20 Study protocol for the randomised controlled trial: Antiglucocorticoid augmentation of anti Depressants in Depression (The ADD Study)

... in depression is often characterised, particularly in those with melancholic symptoms, by a flattened cortisol diur- nal rhythm with elevated trough levels of cortisol [18] and by attenuated negative feedback ... See full document

... current study. Although the trial did not reach its original target of 90% power, it achieved 84% ...the study is not adequately powered to detect differences in these measures of outcome (and these ... See full document

... the trial progresses, we will continue to monitor the situation, and if there are prob- lems associated with recruitment which can be related to the genetic testing, then steps will be undertaken to rectify the ... See full document

... cohort study demonstrated that hyperhomocysteinaemia (plasma level >15 μmol/L), but not total serum folate or vitamin B12, is significantly related to depression severity (odds ratio = ...Another ... See full document

... the randomised control trial we propose is to investigate the antidepressant efficacy of the combined treatment of MDD with antidepressant medication plus anti-inflammatory medication in individuals ... See full document

... of depression, and possibly for an older non-working population, in spite of its efficacy ...ketamine augmentation can significantly reduce the cog- nitive impact of ECT, and it is adopted as a standard ... See full document

... the study team to assess possible eligi- bility using a standard two-question case-finding instru- ment for depression [28] and arrange baseline interviews with potentially eligible and willing participants ... See full document

... This study should not pose any specific risks to individual participants beyond those of any normal maternity care, nor does it raise any extraordinary ethical ...the trial will be submitted to the North of ... See full document

... The trial is powered to detect a 35% difference in effectiveness between PPD and TAU on the Hamilton Depression Rating Scale HRSD-17 [44] with alpha at ...cases randomised equally into two ...another ... See full document

... with depression fail to respond to pharmacological and/or psychological ...of depression and that lifestyle is an important, yet neglected, intervention target for the treatment of ...Our study will ... See full document

... largest study enrolling only 36 ...that anti-platelet agents may increase the primary pat- ency of AVF, the limited evidence base and the uncertainty regarding the choice of agent has not supported the ... See full document

... this protocol generally refers to “non-reassuring fetal status or abnormal /CTG/patterns”, rather than the term “fetal distress”, which is sometimes used inappro- priately to refer to CTGs that do not meet normal/ ... See full document

... Clinical efficacy of computerised cognitive-behavioural therapy for anxiety and depression in primary care: randomised controlled trial.. PHASE: a randomised controlled trial of supervis[r] ... See full document

... Data analysis and reporting will proceed according to CONSORT guidelines for randomised controlled trials, and will be conducted blinded to group status by the trial statistician and researcher. The ... See full document

... Randomisation will be random block size, which will be administered centrally in the Academic Department of Psychiatry and Behavioural Sciences, University of Leeds. Opaque consecutively numbered envelopes will be pre- ... See full document

... LEEDS is intended to complement rather than compete with research taking place in a community primary or sec- ondary care setting. Much of the current evidence base for pharmacological treatment of drug use comes from ... See full document

... this protocol) is not traditionally classified as a sexually transmitted infection, since it occurs in celibate women, and is considered part of the normal vaginal flora ... See full document

... This randomised controlled trial uses a high-reach, low-cost strategy, which can readily be translated into clinical practice in underserved and mi- nority ... See full document

... the study are the following: women aged ≥18 years; excessive gestational weight gain (above the IOM recommendations [5]) in the previous pregnancy; wish for a next pregnancy not ex- cluded; proficiency of Dutch ... See full document

... The goal of this study is to understand the pathogenesis of, and to develop specific interventions for, nodding syn- drome. Currently, there is no specific treatment for nod- ding syndrome. The only available ... See full document