[PDF] Top 20 HIV 1 subtype C Envelope function becomes less sensitive to N glycosylation deletion during disease progression
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HIV 1 subtype C Envelope function becomes less sensitive to N glycosylation deletion during disease progression
... Biotech), 1 U/ mL penicillin and 1 µg/mL streptomycin (Lonza, White- head ...Communicable disease (NICD), South Africa] and Raji DC-SIGN cells (NIH-ARP, from ... See full document
6
Characterization of HIV 1 subtype C envelope glycoproteins from perinatally infected children with different courses of disease
... potential N-glycosylation sites varied among patients but also failed to discriminate between fast and slow ...both sensitive and resistant viruses were transmitted, irrespective of disease ... See full document
15
The V1V2 Domain and an N-Linked Glycosylation Site in the V3 Loop of the HIV-1 Envelope Glycoprotein Modulate Neutralization Sensitivity to the Human Broadly Neutralizing Antibody 2G12
... was sensitive, we ana- lyzed a 3D model of both gp120 proteins in their monomeric and trimeric ...a less compact con- formation than the one shown in our model, while this is probably not the case in the ... See full document
7
A Reliable Phenotype Predictor for Human Immunodeficiency Virus Type 1 Subtype C Based on Envelope V3 Sequences
... type 1 (HIV-1) subtype B infections, the emergence of viruses able to use CXCR4 as a coreceptor is well documented and associated with accelerated CD4 decline and disease ...in ... See full document
7
Influence of Gag-Protease-Mediated Replication Capacity on Disease Progression in Individuals Recently Infected with HIV-1 Subtype C
... slower disease progression in HIV-1-infected individuals with protective HLA ...Gag function on disease progression, the replication capacities of viruses encoding ... See full document
11
Enhanced Fusion and Virion Incorporation for HIV-1 Subtype C Envelope Glycoproteins with Compact V1/V2 Domains
... V1/V2 glycosylation likely affect Env folding in the producer ...potential N-glycosylation sites in the V1/V2 region resulted in increased Env ...of glycosylation in HIV-1 Env, ... See full document
12
tat Exon 1 Exhibits Functional Diversity during HIV-1 Subtype C Primary Infection
... maintaining function, particularly during early infection when the establishment of a productive infection is ...for HIV subtype B and simian immunodeficiency virus (SIV) that tat is one of ... See full document
14
Role of HIV 1 subtype C envelope V3 to V5 regions in viral entry, coreceptor utilization and replication efficiency in primary T lymphocytes and monocyte derived macrophages
... to subtype B chimeras (M5g, M7f, and M1c [34]) and subtype B ...advanced disease (Table 1) ...the subtype C chimeras also replicated at levels higher than the subtype B ... See full document
12
Partial HIV C2V3 envelope sequence analysis reveals association of coreceptor tropism, envelope glycosylation and viral genotypic variability among Kenyan patients on HAART
... by subtype at glycosylation position ...the subtype C isolates were glycosylated compared to ...for subtype D and 100% for subtype A2 or of recombinants of ...of subtype ... See full document
11
Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection
... in HIV-1 subtype B (24, 25). In early HIV-1 infection, we observed a positive correlation between RC and the number of HLA-associated polymorphisms in RT and a weak negative ... See full document
18
HIV 1 subtype C envelope characteristics associated with divergent rates of chronic disease progression
... type C than in subtype B, the a-2 helix is more exposed and more antigenic ...an N to S change at codon 671, which is within a linear epitope- N WFNIT- that is recognized by nAb 4E10, may ... See full document
12
The HIV 1 transmission bottleneck
... for HIV-1 to gain ...trauma during anal intercourse and/or more abundant HIV-1 target cells in the rectal ...of HIV-1 transmission in males are the inner foreskin, tissue ... See full document
19
Gender differences in clinical, immunological, and virological outcomes in highly active antiretroviral-treated HIV–HCV coinfected patients
... In our study, virological and immunological outcomes did not differ by sex in those remaining on therapy. It is noteworthy that the baseline CD4 count at treatment initiation was higher in women. This difference was not ... See full document
7
Covalent Modifications of the Ebola Virus Glycoprotein
... EDTA, 1% sodium deoxycholate, 1% TX-100, ...NaCl, 1% TX-100), and cell lysates were centrifuged in a microcentrifuge at 16,100 ⫻ g for 10 ...of 1 M Tris and vortexed vigorously. Proteins whose ... See full document
10
Linkages between HIV 1 specificity for CCR5 or CXCR4 and in vitrousage of alternative coreceptors during progressive HIV 1 subtype C infection
... for HIV-1 ...file 1: Table S1, and stratified according to dis- ease stage in Figure ...the C-HIV variants from subject 1109, a striking inversion of specifi- city for alternative ... See full document
10
Broadly neutralizing antibodies targeted to mucin-type carbohydrate epitopes of human immunodeficiency virus.
... Inhibition of human immunodeficiency virus HIV infection in vitro by anti-carbohydrate monoclonal antibodies: peripheral glycosylation of HIV envelope glycoprotein gpl20 may be a target [r] ... See full document
7
Genetic analysis of HIV-1 Circulating Recombinant Form 02_AG, B and C subtype-specific envelope sequences from Northern India and their predicted co-receptor usage
... 13 HIV-1 envelope sequences from Northern ...(Pair 1, D & E 57 and Pair 2, D & E 58) were selected randomly from two locations (one from GTB Hospital, Delhi - Samples ND1 to 5, all ... See full document
6
Fluidity of HIV-1-Specific T-Cell Responses during Acute and Early Subtype C HIV-1 Infection and Associations with Early Disease Progression
... responses during acute in- fection and suggest that neither a static measurement nor the magnitude of response alone is enough to determine the course of viremia ... See full document
12
Characterization of Human Immunodeficiency Virus Type 1 (HIV-1) Envelope Variation and Neutralizing Antibody Responses during Transmission of HIV-1 Subtype B
... of N-linked glycosylation sites (NGS), which anchor a “glycan shield” of carbohydrates to the envelope (7), and vari- able loops that bind antibodies, may contribute to escape from neutralizing ... See full document
5
HIV Associated Polyneuropathy in Resource Limited Settings: Genetic Predisposition and Vitamin Variations
... Susceptibility to PN varies among HIV-infected persons, with prevalence rates reported to range from 10% - 35% [74]. The variability suggests a role for human genomic variation, though with much focus on ... See full document
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