[PDF] Top 20 Subtyping of microsatellite instability-high colorectal cancer
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Subtyping of microsatellite instability-high colorectal cancer
... with microsatellite instability low (MSI-L) or microsatellite stable (MSS) CRC ...to microsatellite instabil- ity in predicting patients ’ disease-specific recurrence ... See full document
10
Spontaneous regression of transverse colon cancer with high frequency microsatellite instability: a case report and literature review
... of colorectal cancer (CRC) is extremely rare, and only few cases have been ...sporadic high-frequency microsatellite instability ... See full document
6
Subcellular protein expression models for microsatellite instability in colorectal adenocarcinoma tissue images
... the cancer samples there are a number of non-MSI samples and cells that have the same pro- tein expressions as the healthy ...the cancer samples into three sets depending on the presence of a ... See full document
24
Assessment of clinically related outcomes and biomarker analysis for translational integration in colorectal cancer (ACROBATICC): study protocol for a population based, consecutive cohort of surgically treated colorectal cancers and resected colorectal liver metastasis
... of microsatellite instability (MSI) and specifically a form found in tetranucleotide repeats (elevated microsatellite alterations in selected tetranucle- otides; EMAST), which is found at varying ... See full document
9
Colorectal Tumour Microsatellite Instability Test Results: Perspectives from Patients
... The MSI/IHC story is more complex than just a negative or a positive result. In any series of colon cancers not preselected for high risk features (i.e., young age at diagnosis or multiple affected family ... See full document
7
Prediction of biological behavior and prognosis of colorectal cancer patients by tumor MSI/MMR in the Chinese population
... Abstract: Colorectal cancers (CRCs) exhibiting microsatellite instability (MSI) have special biological ...having high microsatellite instability, 156 ...having ... See full document
10
Mismatch repair deficiency/microsatellite instability-high as a predictor for anti-PD-1/PD-L1 immunotherapy efficacy
... duce microsatellite instability ...tional Cancer Institute in 1998 [21 – ...be microsatellite instability-low ...have microsatellite stability (MSS). There is a high level ... See full document
14
Mutational profiling of colorectal cancers with microsatellite instability
... homopolymer regions as well as artifacts due to mispriming events intrinsic to multiplex PCR-based assays [35]. A background noise cutoff of 2% was chosen for single nucleotide variations based on analysis of 16 non- ... See full document
11
Context matters-consensus molecular subtypes of colorectal cancer as biomarkers for clinical trials.
... Colorectal cancer (CRC) is highly heterogeneous at the genomic and transcriptomic levels ...namely microsatellite instability (MSI) and extended RAS and BRAF mutational status, are routinely ... See full document
8
<p>Evaluation of Concordance Between Deficient Mismatch Repair and Microsatellite Instability Testing and Their Association with Clinicopathological Features in Colorectal Cancer</p>
... costly, high requirement and time- consuming in NGS ...National Cancer Institute (NCI)-sponsored MSI workshop and Promega systems (5 mononucleotide repeats) emerged ... See full document
11
Aberrant DNA methylation profiles of inherited and sporadic colorectal cancer
... (Lynch colorectal cancer with microsatellite instability (LS-MSI)), 23 CRCs of patients under 40 years in which the main inherited CRC syndromes had been excluded (early-onset ... See full document
12
Somatic microsatellite variability as a predictive marker for colorectal cancer and liver cancer progression
... MSI is a measure of the frequency of altered primary alleles relative to a patient’s germline within a select set of microsatellite loci. To date, the only clinically approved test for MSI (Promega, Fitchburg WI) ... See full document
12
H. pylori infection is related to mitochondrial microsatellite instability in gastric carcinogenesis
... gastric cancer [31, ...the high rate of ROS generation in this organelle and its inefficient DNA repair system [33, ...gastric cancer [31, ... See full document
8
Current applications of molecular pathology in colorectal carcinoma
... chromosomal instability pathway, the microsatellite instability pathway, and the CpG island methylator phenotype ...of colorectal carcinoma and our ability to treat it will advance in the ... See full document
13
No Change in Frequency of Microsatellite Instability in Colorectal Cancers over a Period of 15 or More Years
... Microsatellite instability (MSI) is a molecular change resulting from inactiva- tion of DNA mismatch repair systems, occurring with a reported incidence between 15% - 20% of all sporadic colorectal ... See full document
7
Molecular genetics of microsatellite-unstable colorectal cancer for pathologists
... Answer: The criteria for interpreting MMR IHC in an adenoma are the same as for cancer. It has been shown that 50% to 72% of conventional adenomas from mutation carriers show loss of MMR protein expression ... See full document
12
Microsatellite instability in prostate cancer by PCR or next-generation sequencing
... In summary, our study demonstrates that expanded panel MSI NGS assays performed well in prostate can- cer, and that the conventional 5-marker capillary electro- phoresis MSI-PCR assay had inferior sensitivity. Both NGS ... See full document
7
Assessing the potential value of long interspersed element-1 hypomethylation in colorectal cancer: evidence from retrospective studies
... in cancer cells, which has great importance during colorec- tal ...genomic instability which supporting the hypothesis that genome-wide hypomethylation might be involved in the pathway connected with MSI ... See full document
12
The immunogenicity of colorectal cancers with high degree microsatellite instability
... sporadic colorectal can- cers. In HNPCC colorectal cancers a germline mutation within an individual mismatch repair gene is inherited and a subsequent "second hit" [Knudson's 'two-hit' hypothesis ... See full document
9
Clinical Implications of Microsatellite Instability in T1 Colorectal Cancer
... T1 colorectal cancer is based on histologic examination and imaging of the primary ...tumor. High-frequency microsatellite instability (MSI-H) is likely to decrease the possibility of ... See full document
7
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