[PDF] Top 20 Sunitinib in the treatment of gastrointestinal stromal tumor: patient selection and perspectives
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Sunitinib in the treatment of gastrointestinal stromal tumor: patient selection and perspectives
... of sunitinib on schedule 4/2 were tested; 50 mg/day on schedule 4/2 until progression disease (PD) and/or unacceptable toxicity was defined as recommended phase II dose and after that several dose-limiting ... See full document
10
Surgery after treatment with imatinib and/or sunitinib in patients with metastasized gastrointestinal stromal tumors: is it worthwhile?
... on sunitinib underwent ...no tumor rupture occurred during ...One patient in the responders group under- went a R0 resection of the left vastus medialis muscle because of an unusual metastasis at ... See full document
7
Clostridium perfringens Septicemia and a Bleeding Ulcer of a Jejunal Interposition: A Case Report and Short Review of the Literature
... female patient presented to our emergency department with acute onset of hematemesis and ...the patient appeared to have a poor general health condition and was hemodynamically ...The patient had a ... See full document
5
Targeting gastrointestinal stromal tumors: the role of regorafenib
... Understanding genetic signatures and complex signaling networks are crucial for yielding successful outcomes using targeted therapies. Since regorafenib targets multiple kinases, further investigation of the interplay ... See full document
8
Patient preferences for reducing toxicities of treatments for gastrointestinal stromal tumor (GIST)
... Gastrointestinal stromal tumors (GISTs) are a type of cancer that develops in the supportive or connective tissues of the digestive ...and sunitinib block the tyrosine kinase enzymes that GISTs need ... See full document
8
Liver surgery prolongs the survival of patients with gastrointestinal stromal tumor liver metastasis: a retrospective study from a single center
... Our study has some limitations. First, as a retrospec- tive study, selection bias is unavoidable. Patients with less metastases were more likely to be selected for surgery. Sec- ond, due to the scarcity of this ... See full document
7
Inactivity of imatinib in gastrointestinal stromal tumors (GISTs) harboring a <em>KIT </em>activation-loop domain mutation (exon 17 mutation pN822K)
... macroscopic evidence of the disease. Later, a third recurrence was excised (sunitinib was given in absence of the macroscopic disease so it cannot be speculated if the disease was responsive to sunitinib) ... See full document
7
Small intestinal gastrointestinal stromal tumor in a young adult woman: a case report and review of the literature
... tations. Sunitinib is another approved drug and an inhibi- tor of multiple tyrosine kinases including KIT, PDGFRA as well as platelet-derived growth factor receptor beta and vascular endothelial growth factor ... See full document
7
Generation of orthotopic patient derived xenografts from gastrointestinal stromal tumor
... [9-12]. Sunitinib (Sutent, Pfizer, New York, NY), a multikinase inhibitor with activity against PDGFR, VEGFR and KIT, is employed as second line ther- apy for ...of sunitinib-treated patients have ... See full document
11
Response to sunitinib of a gastrointestinal stromal tumor with a rare exon 12 PDGFRA mutation
... a gastrointestinal stromal tumor (GIST). The patient was treated with neoadjuvant imatinib 400 mg ...With treatment, the mass signifi- cantly reduced in size to ...the tumor ... See full document
5
Gastrointestinal schwannomas: a rare but important differential diagnosis of mesenchymal tumors of gastrointestinal tract
... as tumor size and mitotic rate seem not to have any prognostic ...the treatment of choice because of the preoperative diagnostic uncer- tainty and the excellent long-term outcome, as these tumors are ... See full document
7
Patient selection and targeted treatment in the management of platinum-resistant ovarian cancer
... superfluous treatment to those who are biomarker negative; this approach should lead to improved clinical results and decreased ...OC patient populations that may benefit from specific targeted therapies is ... See full document
13
Secukinumab in the treatment of psoriasis: patient selection and perspectives
... so treatment of joint symptoms in addition to skin symptoms is critical to prevent irreversible joint ...the treatment of both psoriatic arthritis and psoriasis vulgaris, a group that also includes ... See full document
8
Bevacizumab in the treatment of NSCLC: patient selection and perspectives
... Eligibility for bev is not affected by patient age, performance status, anticoagulation therapy, and brain metastases. The only absolute contraindications to its use are squamous histology and a history of ... See full document
11
Management of a case of high risk gastrointestinal stromal tumor in rectum by transanal minimal invasive surgery
... The patient was kept in the modified lithotomy pos- ition, and the anus dilated with a self-retaining anal re- tractor (Lone Star Retractor; Cooper Surgical, Trumbull, CT, ...The tumor was located ... See full document
5
Patient considerations and drug selection in the treatment of idiopathic pulmonary fibrosis
... Patients were recruited from 127 centers across nine countries if they met the following criteria: age between 40 and 80 years, diagnosis of UIP on HRCT or surgical lung biopsy, FVC 50%−90%, DLco 30%−90% predicted, FEV 1 ... See full document
12
Gastrointestinal Stromal Tumor in Pregnancy: A Case Report
... After the third operation patient’s condition improved rapidly. Pregnancy was uncomplicated until week 41 of gestation, when she developed a mild pregnancy induced hypertension. No antihypertensive treatment was ... See full document
5
Inflammatory pseudotumor of the liver diagnosed as metastatic liver tumor in a patient with a gastrointestinal stromal tumor of the rectum: report of a case
... symptoms or notable laboratory findings were present. The patient received regular follow-up, in accordance with his post-operative status of malignant rectal GIST. However, the liver lesion appeared suddenly. ... See full document
6
A gastrointestinal stromal tumor with mesenteric and retroperitoneal invasion
... CT findings of GISTs are well described in the radiological literature [8-13]. Malignant GISTs are typically extralumi- nal, large (>5 cm), well-circumscribed, heterogeneous, centrally necrotic tumors. Such features ... See full document
6
Primary omental Gastrointestinal stromal tumor (GIST)
... GISTs are mesenchymal tumors, the majority of which is KIT (CD117)-positive, typically arising in association with the muscularis propria of the gastrointestinal tract wall. Accordingly, they occur most frequently ... See full document
5
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