[PDF] Top 20 Superiority and non inferiority: two sides of the same coin?

... In superiority trials, a rigorous primary analysis should in- clude all randomised patients, irrespective of whether they took study medication as randomised ...Historically, non-inferiority trials ... See full document

... The ultrasound scan is very attractive to pregnant women [3]. They expect the scan to confirm the well- being of the fetus, and to provide a visual encounter with their ‘baby’ [7, 8]. For expectant fathers the ultra- ... See full document

... a non-crisis ...a non-crisis situation in terms of our dataset, we are aware that what occurs in such a situation contributes to any subsequent crisis ... See full document

... clinical superiority of a drug versus pla- cebo would need to be proven in order to claim clinical ...environment, two approved drugs for the same indication will usually have very similar label ... See full document

... One limitation of our study is that data were only analysed at one medical school. The mediocre amount of medical information gathered from history taking and the non-correlation with empathy scores rated by ... See full document

... marshalling human and non-human resources. But according to Churchill and Muzyka (1994), the Western model of entrepreneurship is not totally applicable to developing countries, Nigeria inclusive. Therefore, ... See full document

... Recently, researchers are doing wide studies on the TGF-β signaling pathways. Three isoforms endow with the TGF-β of mammals, namely TGF-β1, TGF-β2, and TGF-β3 [9]. Each TGF-β is differentially expressed and activated ... See full document

... The impending growth in advertising has incited several criticisms. Advertising is believed to have influenced and manipulated consumer’s everyday lives (Packard, 1957). It has provided advertising agencies the skill in ... See full document

... are non-inflammatory digital arthropathies with phenotypic ...the two entities. Our analysis suggests that these two phenotypes may represent phenotypic variability of the same ... See full document

... Not only did Gilbert find that internal interactions are similar to external interactions but he also found that the forms and functions of self-criticism may be similar to forms of behaviour which are aimed at ... See full document

... the non- inferiority of the beta-lactam strategy to the beta-lactam- macrolide and fluoroquinolone strategies with respect to 90-day mortality using a noninferiority margin of 3 per- centage points and a ... See full document

... are two forms of intestinal BD lesions: one is mucosal inflammation and ulceration (neutrophilic phlebitis), the other is ischemic damage (vasculitis) ...of non-caseating granuloma suggests intestinal BD ... See full document

... Table 1 presents the summary statistics for the levels of bank CDS spreads (Panel A) and sovereign CDS spreads (Panel B). We can note how bank CDS spreads show a higher mean and volatility than sovereign CDS spreads. ... See full document

... parallel two-group post market ...time. Non-inferiority will be investigated for primary endpoints 1 (t-test confidence interval) and 2 (Wilson ’ s score interval) using both the full analysis set ... See full document

... determine the identity of the particle. There are only two kinds of particles that are massless and travel at lightspeed: photons and neutrinos. Neutrinos may immediately be disqualified since they display no ... See full document

... intensities for peaks at 1670 cm –1 (proteins), 2850 cm –1 (lipids), 785 cm – 1 (nucleic acids), and the combination of 748 cm –1 with 1585 cm –1 (cytochrome C) are mapped in blue, green, red, and magenta, respectively. ... See full document

... distribution. Two mechanisms can achieve the necessary size mixing to provide this smoothing: first, the fact that cells do not split only when they exactly reach the size w ∗ , and ... See full document

... Recently, it has been shown that p53/Mdm2 alterations are found only in platinum-extreme resistant TGCT patients [26], but, as noted above, most non platinum-responders TGCT are p53 wild-type, pointing out the ... See full document

... Corporate users of the system might include P2P developers, who could use the system to assess the market penetration of their P2P products, and the music and film industry that might use the system to assess the extent ... See full document

... continued as long-term follow-up was awaited to confirm the advantage of coiling over clipping. Ultimately, long- term follow-up outcomes in both studies were evaluated at 18 and 3 years, respectively, and an attenuation ... See full document