[PDF] Top 20 Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo
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Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo
... of mouse and rat through application of small- molecule inhibitors of the fibroblast growth factor (FGF)/Erk pathway and of glycogen synthase kinase ...of Erk signalling from the 8-cell stage ... See full document
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NOTCH activation interferes with cell fate specification in the gastrulating mouse embryo
... NOTCH signalling is an evolutionarily conserved pathway involved in intercellular communication essential for cell fate choices during ...of mouse development, canonical RBPJ-dependent NOTCH ... See full document
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Axolotl Nanog activity in mouse embryonic stem cells demonstrates that ground state pluripotency is conserved from urodele amphibians to mammals
... We next tested whether axNanog could repress differentiation in embryoid bodies (EBs) (Darr et al., 2006; Hamazaki et al., 2004). EBs were produced from Nanog-expressing ESCs and gene expression was assayed at various ... See full document
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Retinoic acid orchestrates fibroblast growth factor signalling to drive embryonic stem cell differentiation
... differentiation. Signalling via the fibroblast growth factor (Fgf)/Erk pathway is required to progress from this dynamic state and promote mouse ES cell ...Fgf/Erk signalling in ... See full document
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Klf4 reverts developmentally programmed restriction of ground state pluripotency
... conventional mouse ES cell culture conditions (Brons et ...kinase signalling cascade and glycogen synthase kinase 3 (Gsk3) provide, in combination with Lif, an optimal environment for derivation and ... See full document
7
Live imaging of ERK signalling dynamics in differentiating mouse embryonic stem cells
... of ERK activity during the exit from the naïve state, a k-means clustering algorithm was used to group cells based on their ERK activity profile during the 16 h ...distinct ERK ... See full document
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RhoA and ERK signalling regulate the expression of the transcription factor Nfix in myogenic cells
... From a biological perspective, our findings represent an important step towards understanding the molecular regulation of Nfix expression, and therefore the definition of embryonic and foetal myogenic identities. ... See full document
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The roles of BMP and IL 3 signaling pathways in the control of hematopoietic stem cells in the mouse embryo
... HSCs found in the adult are not produced in the BM but earlier during embryonic development (Cumano and Godin, 2007, Dzierzak and Speck, 2008). In contrast to the adult, HSCs reside in different anatomical sites and are ... See full document
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Vasculogenesis and angiogenesis in the mouse embryo studied using quail/mouse chimeras
... that mouse embryonic tissues are differently vascularized depending on their somatopleural or splanchnopleural origin raises the question whether these different processes are related to the existence of two ... See full document
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Connexins: Synthesis, Post-Translational Modifications and Trafficking in Health and Disease
... HeLa cells increases Cx43 expression, promotes gap junction formation and increases signalling.. 478.[r] ... See full document
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A genome wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency
... Oct4 is downregulated by 24 hours in parental EpiSCs transferred to 2i/LIF, but we noted that expression is maintained in Nr5a transfectants. Nr5a1 and Nr5a2 have been reported to bind to Oct4 upstream elements and ... See full document
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Perspectives of TGF-β inhibition in pancreatic and hepatocellular carcinomas
... Many lines of preclinical evidence suggest that TGF-β plays a crucial role in immune regulation[108, 109]. The immune system is responsible for the early detection and destruction of cancer cells. Some cancer cells ... See full document
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Reprogramming cell fate to pluripotency: the decision making signalling pathways
... p53 promotes maturation of pre-miR-145 to mature miR-145, so p53-mediated miR-145 down-regulation might also allow transcription of endog- enous Oct4, Sox2 and Klf4, which are essential for self-renewal (Suzuki et ... See full document
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Activin/Nodal signalling maintains pluripotency by controlling Nanog expression
... conditions, 90% of both wild-type and NANOG-hESCs were positive for the pluripotency marker TRA-1-60 (see Fig. S5B in the supplementary material), whereas after 7 days of BMP4 treatment only 25-35% of either ... See full document
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Elevated Kallikrein-binding protein in diabetes impairs wound healing through inducing macrophage M1 polarization
... Background: The accumulation of M1-polarized macrophages and excessive inflammation are important in the pathogenesis of diabetic foot ulcer (DFU). However, the underlying mechanism of DFU pathogenesis and the crucial ... See full document
15
Mouse embryo assay to evaluate polydimethylsiloxane (PDMS) embryo-toxicity
... preimplantation embryo development in vitro, to limit the amount and the consumption of medium, and to mimic the natural fluid flow that draws the zygotes through the fallopian tube to the site of implantation in ... See full document
5
Hedgehog signalling is required for cloacal development in the zebrafish embryo
... To investigate the temporal requirements for Hh signalling during posterior gut development, we used the alkaloid cyclopamine to inhibit the activity of Smo (Fig. 7). Exposure to cyclopamine, (followed by its ... See full document
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Brfl Post-Transcriptionally Regulates Pluripotency and Differentiation Responses Downstream of Erk MAP Kinase
... of pluripotency, self-renewal and differentiation in ...key pluripotency-associated genes, reduces the capacity to self-renew, and enhances mesendoderm differentiation upon LIF ... See full document
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2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline.
... the Erk signaling pathway by 2-O sulfation in the E12.5 developing mouse brain (Fig ...turn promotes the formation of the HS:Fgf2:Fgfr1 signaling complexes causing high Erk phosphorylation ... See full document
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PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud
... Fig. 5. Prmt5 cKO limb buds have elevated apoptosis and precocious differentiation in the distal limb bud. Immunostaining for cleaved caspase 3 (A,D) and double staining for cleaved caspase 3 ( pink) and SOX9 (green) ... See full document
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