[PDF] Top 20 Down syndrome mouse models have an abnormal enteric nervous system
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Down syndrome mouse models have an abnormal enteric nervous system
... two mouse DS models, one partial trisomy and one transchromosomal, have submucosal plexus hypoganglionosis, but critical genes causing this problem remain ...prevent enteric neuron apoptosis ... See full document
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Oleic Acid and Cholinergic dysfunction in Down Syndrome Models of the Central Nervous System
... 18. Saud K, Arriagada C, Cárdenas AM, Shimahara T, Allen DD, Caviedes R, et al. Neuronal dysfunction in Down syndrome: contribution of neuronal models in cell culture. J Physiol Paris. 2006; 99(2-3): ... See full document
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White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies.
... of enteric neurons (Knowles et ...hypoperistalsis syndrome, X-linked intestinal pseudo-obstruction) were later shown to be dis- orders of smooth muscle (Kapur et ...studies have examined ... See full document
23
Electroacupuncture at acupoint ST 37(Shangjuxu) improves function of the enteric nervous system in a novel mouse constipation model
... an abnormal neurotransmitter content have been considered to be responsible for primary chronic constipation ...the enteric neurons, leading to improvement of the impaired ENS ... See full document
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Emerging roles of gut microbiota and the immune system in the development of the enteric nervous system
... a mouse model of congenital aganglionosis ...in enteric neuron connectivity and gastrointestinal motility (125) and whether such potential deficits represent direct effects of ENS circuits on microbiota or ... See full document
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Title: The Enteric Nervous System and Its Emerging Role as A Therapeutic Target
... the enteric neurons and intestinal endocrine cells as demonstrated in the mouse, rat, pig and human intestines [65, 67, 123, ...the enteric neuron is exposed to GLP-2, it results in expansion of the ... See full document
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Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury
... bowel syndrome (46, ...of enteric glia into neurons, this could have therapeutic implications for the treatment of severe inflammatory conditions of the ...of enteric glia could facilitate the ... See full document
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The effect of intestinal inflammation and enteric nervous system deregulation in the pathogenesis of Parkinsonian syndrome
... signaling (Neunlist et al., 2003). However, do the effects on the ANS lead to changes in the CNS? To answer this pertinent question, we used a known mouse model of UC. C3H mice given 3% DSS for 7 days followed by ... See full document
261
Deletion of Pten in the mouse enteric nervous system induces ganglioneuromatosis and mimics intestinal pseudoobstruction
... Thus, we initially investigated PTEN pro- duction in patients presenting with Cowden syndrome associated with GNM. Unfortu- nately, we were unable to obtain appropri- ate material for immunohistochemical analyses. ... See full document
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Dlx1/2 mice have abnormal enteric nervous system function
... backgrounds were reported to die by 1 month of age (14, 15), a time frame similar to mouse models with defined enteric neuropathies (12, 16). Consistent with the hypothesis that Dlx1 and Dlx2 ... See full document
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Original Article Morphological changes in the enteric nervous system of rats with functional dyspepsia and the therapeutic effects of electroacupuncture at zusanli (ST36)
... Relevant nerve fibers were stained using the primary antibodies specific for vesicular acetyl- choline transporter (VAChT), substance P (SP), vasoactive intestinal polypeptide (VIP) and neu- ronal nitric oxide synthase ... See full document
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Key words
... family have been given the syste− matic designation SLC39 and they were thought to play an important role in zinc transport from out− side the cell into the ...family have been described in mouse and ... See full document
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Achalasia cardia – An observational study on histopathological, ultrastructural, manometric features and analysis of short term surgical outcomes after laparoscopic Heller’s myotomy
... they have very poor support systems outside the hospital, so we tend to keep them in hospital longer than required which could explain the increased hospital ... See full document
113
Enteric Ganglionitis in Rhesus Macaques Infected with Simian Immunodeficiency Virus
... the enteric nervous system (ENS) of macaques during the acute stage of simian immunodeficiency virus (SIV) infection to gain insight into potential pathogenic mechanisms of GI ... See full document
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From mice to men: lessons from mutant ataxic mice
... birth, abnormal- ities develop dramatically when the granule cells begin to migrate, so that by P10 developmental defects are markedly present ...with abnormal glial processes and cells that have ... See full document
21
Molecular characterisation of sneezy, a notochord mutation
... COPI vesicles are functionally and structurally distinct from others vesicles such as COPII vesicles. The structure of the main component of their coat, the coatomer, has been investigated and many interactions between ... See full document
186
Experimental Models of Irritable Bowel Syndrome and the Role of the Enteric Neurotransmission
... bowel syndrome (IBS) is a highly prevalent (12-20% in western countries) and multifactorial gastrointestinal disorder (1) whose symptoms are mainly referred to the large ... See full document
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lessen encodes a zebrafish trap100 required for enteric nervous system development
... The lsn w24 (AB background) mutation was mapped by out-crossing into the polymorphic wild-type strain WIK, followed by in-breeding of heterozygous progeny. We scanned the genome for linked SSLP markers by bulked ... See full document
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Modulation of lipopolysaccharide-induced neuronal response by activation of the enteric nervous system
... markers: mouse anti-Hu (1:200; Molecular Probes?, Life Technologies), rabbit ...France), mouse anti-Sox10 (1:500; R&D systems, Minneapolis, Minnesota, United States), rabbit anti-S100b (1:1,000; ... See full document
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The enteric nervous system of echinoderms: unexpected complexity revealed by neurochemical analysis
... A putative neuronal network associated with the intestinal connective tissue has been described in our laboratory (García- Arrarás et al., 1999) (Fig. 9). Although the characterization of this plexus is incomplete at ... See full document
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