[PDF] Top 20 Synthesis and antitumor activity of novel pyrazolo[3,4 d]pyrimidin 4(5H) one derivatives
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Synthesis and antitumor activity of novel pyrazolo[3,4 d]pyrimidin 4(5H) one derivatives
... benzaldehyde, 3-hydroxybenzaldehyde, 4- chlorobenzaldehyde, 4-dimethylaminobenzaldehyde, 4-nitrobenzaldehyde in ethanol containing catalytic amount of glacial acetic acid gave compounds 6a-e ... See full document
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“Synthesis and Antitumor Activity of Novel Pyrazolo[3,4-D]Pyrimidine and their Tricyclic Derivatives” by Phoebe, F. Lamie, Egypt.
... Novel pyrazolo[3,4-d]pyrimidine derivatives carrying different groups at position 6 and varieties of tricyclic structures containing pyrazolopyrimidine core were synthesized aiming at having ... See full document
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Synthesis, characterization and In vitro antimicrobial evaluation of novel pyrazolothiazol-4(5H)-one derivatives
... The synthesis of compounds (3a‑3j) was followed by the general pathway outlined in Scheme ...N‑thiocarbamoylpyrazole derivatives (2a‑2j). In the last step, pyrazolothiazol‑ 4(5H)‑one ... See full document
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SYNTHESIS AND ANTICANCER ACTIVITY OF SOME NOVEL 3- [(2-SUBSTITUTED-6,7,8,9-TETRAHYDRO-5H-CYCLOHEPTA[b] THIENO [2,3-d]PYRIMIDIN-4-YL)AMINO]PROPAN-1-OL
... plates. 4. The plates were then incubated at 37 °C for 3 days in 5% CO atmosphere and microscopic examination was carried out and observations recorded every 24 ... See full document
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Synthesis, characterization and biological activity of novel 3 benzyl 2 phenyl 4(5H) (substituted phenylhydrazino) 1,3 oxazolidines derivatives
... anti-fungal activity when compared to standard drug Ciprofloxacin and Ketoconazole for anti-bacterial and anti-fungal activity ...anti-microbial activity where as the remaining compounds shown good ... See full document
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Synthesis and antitumor activity of novel pyrazolo[3,4 d]pyrimidines and related heterocycles
... of pyrazolo[3,4-d]pyrimidine with imino 2a or hydrazine 3 groups at position 4 of the pyrimidine ...the pyrazolo[3,4-d]pyrimidine nucleus and replaced the 2-(2-furyl)-triazole ... See full document
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Synthesis, Characterization and Antidepressant activity of 2-Thioxo-5H-Pyrrolo[3,4-D]Pyrimidin-5-One Derivatives.
... The main biochemical theory of depression is the monoamine hypothesis, proposed by Schildkraut in 1965, which states that depression is caused by a functional deficit of monoamine transmitters at certain sites in the ... See full document
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Synthesis of 2 phenyl 3H dipyrimido[1,2 a] pyrimidin 4(5H) one derivatives and their antifungal activity
... The synthesized compounds (6a-j), in measured quantities, were dissolved in dimethyl sulphoxide (DMSO) in a final concentration of 50 µ g ml. The synthesized compounds were evaluated for antifungal activity by ... See full document
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Synthesis, reactivity and antitumor activity of some new pyrazolo[3,4-d] pyrimidine and their triazole derivatives
... To a solution of 2 (2.6 g, 0.01 mol) in 10% alcoholic KOH (10ml), carbon disulfide (10ml) was added. The reaction mixture was refluxed for 2 hours, cooled, poured onto cold water and neutralized with 1M HCl. The solid ... See full document
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Design, Synthesis and In vitro Antioxidant, Antitumor and Antimicrobial activity of Some Novel 2,3-disubstituted quinazoline-4(3H)-One Derivatives.
... The adverse effects of oxidative stress on human health have become a serious issue. The World Health Organization (WHO) has estimated that 80% of the earth’s inhabitants rely on traditional medicine for their primary ... See full document
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Synthesis and alkylation of 1 aryl 1,5 dihydro 4 H pyrazolo[3,4 d ]pyrimidin 4 ones as possible anticonvulsant agents
... Pyrimidine derivatives make a major interest as potential neurotropic drugs, among which condensed with other nitrogencontaining heterocycles derivatives [1-5] take a special ...neurotropic activity ... See full document
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H NMR, 13 C NMR, mass spectra and elemental analysis. All the
... the synthesis of a novel series of pyrazolo[3,4-d]pyrimidine derivatives by incorporating the phenothiazine and pyrazolo[3,4- d]pyrimidine in a single molecular framework ... See full document
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SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL 1, 3, 4-THIADIAZOLE DERIVATIVES
... A.S. Synthesis of 1,3,4- thiadiazoles, imidazo[2,1-b]1,3,4-thiadiazoles and thiadiazolo[3,2-a]pyrimidines derived from benzimidazole as potential antimicrobial ... See full document
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Synthesis, Characterization and In Vitro Antitumor Evaluation of New Pyrazolo[3,4 d]Pyrimidine Derivatives
... synthesized derivatives were evaluated for antitumor activity by measuring the inhibitory effect of such compounds against human breast ade- nocarcinoma cell line MCF7 using MITT technique [21] ... See full document
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Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives
... the synthesis of hitherto unknown fused ...derivative 3 on the basis of ana- lytical and spectral data (Scheme ...of 3 from the reaction of 2 with malononitrile is believed to be formed via initial ... See full document
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Synthesis and Biological Studies of Pyrazolo [3, 4-d] Pyrimidines
... An novel series of the pyrazolo [3,4-d] pyrimidines (IIIa-n) were prepared via one pot reaction of 4-amino-5-cyano-6-aryl-2- mercapto-5,6-dihydro pyrimidines(I) with hydrazine ... See full document
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Synthesis, characterization, and antimicrobial evaluation of novel 5-benzoyl-<em>N</em>-substituted amino- and 5-benzoyl-<em>N</em>-sulfonylamino-4-alkylsulfanyl-2-pyridones
... In the present work, the antifungal and antibacterial poten- tials of synthesized compounds were evaluated against C. albicans, S. aureus, and E. coli using well diffusion tests. Inhibition-zone diameters for C. albicans ... See full document
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Synthesis of Some Derivatives of the 4H-pyrido[4′,3′:5,6]pyrano[2,3-d]pyrimidines
... To the 25 mL 1-pentanol was added 10 mmol (2.50 g) of 5-hydroxy-2-methyl-imino-8-methyl- 2H-pyrano[2,3-c]pyridine-3-thiocarboxamide, 15 mmol of the corresponding aromatic aldehyde and 1 mmol (0.6 mL) of ... See full document
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One-pot, four component synthesis of pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidines derivatives
... To find the best solvent for this reaction, we repeated the same model reaction by using various solvents such as acetonitrile (MeCN), dichloromethane (DCM), tetrahydrofuran (THF), and water. Among the all these ... See full document
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REVIEW: SYNTHESIS SCHEMES OF ANTIMICROBIAL AND ANTICANCER THIAZOLE DERIVATIVES
... of novel heterocyclic compounds of anticipated utility as anticancer ...as antitumor agents is one of the most urgent research areas in contemporary medicinal ...Thiazole derivatives have been ... See full document
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