Top PDF Synthesis and Characterization of Some New Quinolinic acid Derivatives

Synthesis and Characterization of Some New Quinolinic acid Derivatives

Synthesis and Characterization of Some New Quinolinic acid Derivatives

Preparation of some non-homogeneous cyclic compounds starting with Quinolic acid .A different N- heterocyclic substituted derivative of quinolone has been synthesized. The nitrogen atoms have been alkylated first to form N-carboxymethyl followed by cyclization reaction to form heterocyclic/substituted aryl groups. All the synthesized compounds have been identified using FT-IR, 1 H NMR spectrum.

5 Read more

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SOME NOVEL ASPARTIC ACID DERIVATIVES OF NUCLEOBASE

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SOME NOVEL ASPARTIC ACID DERIVATIVES OF NUCLEOBASE

1. Manish C haudhari, Dhaval Bhanotar, Dilip Gami, Jahnvi Darji, Dipa Dabhi, Shyamali Panchal. Synthesis, characterization and antimicrobial activities of some novel Alanine deriveives of RNA & DNA base, International Research Journal of Natural and Applied Sciences.,Vol. 4, Issue 5, May 2017

10 Read more

Synthesis, characterization & biological activity of some new thiosemicarbazide derivatives and their transition metal complexes

Synthesis, characterization & biological activity of some new thiosemicarbazide derivatives and their transition metal complexes

A synthesis of some new thiosemicarbazide like acetyl hexan thiosemicarbazide by condensation of cyclohexylmethylketone with thiosemicarbazide is carried out. And their metal complexes were synthesized by condensation of acetylhexan thosemiocarbazide and different transition metal chloride salt of Cu(II), Co(II), Ni(II),Cd(II),Zn(II),Hg(II) and Fe(III) their characterization are done by different analytical techniques, such as elemental analysis,FT-IR, ES-Mass .

9 Read more

Synthesis, characterization and antibacterial activity of some new chalcone derivatives

Synthesis, characterization and antibacterial activity of some new chalcone derivatives

Chalcones having an α, β unsaturated carbonyl group are versatile synthons for various chemical transformations. Chalcones have been used as anticancer, anti-inflammatory and antioxidant agents [1], antimicrobial activity [2], anti-infective and anti-inflammatory [3], antitumor agents [4], antimalarial and antitubercular activity [5], anti AIDS agents [6], cytotoxic agents with antimalarials [7]. Furthermore chalcones are known to exhibit as inhibitors of mycobacterial FAS-II and PknG [8], inhibitors of breast cancer resistance protein [9], inhibitors and promoters of tubulin polymerization [10], inhibitors of TNF-a and IL-6 with antimicrobial activity [11] and inhibitors of the voltage-gated potassium channel Kv1.3 [12]. Infectious diseases caused by bacteria have increased tremendously in recent years. Though many significant advances have been made in antibacterial therapy, the widespread use and misuse of antibiotics have caused the emergence of bacterial resistance to antibiotics [13-15]. A survey based on a structural activity relationship study revealed that certain small heterocyclic molecules act as highly functionalized scaffolds and are known pharmacophores of a number of biologically active and medicinally useful molecules [16,17]. Encouraged by the various biological activities associated with chalcones derivative, we report herein the synthesis, characterization and antibacterial activity of fifteen new chalcone derivatives derived from 3-methoxy-4- hydroxy-acetopheneone (apocynin) [18] bearing 3-chloro benzyl entity.
Show more

6 Read more

Synthesis and Characterization of New Heterocyclic Compounds from 2, 5- dimercapto -1, 3, 4-Thiadiazole and Their Resins

Shetha F.Al-Zubiady | Israa Abdul Satar Ismael | Ban Dh. Ismael

Synthesis and Characterization of New Heterocyclic Compounds from 2, 5- dimercapto -1, 3, 4-Thiadiazole and Their Resins Shetha F.Al-Zubiady | Israa Abdul Satar Ismael | Ban Dh. Ismael

ring system described for the first time in 1890 by Freund and Kuh [1]. They found when a substitution occur in locations (2,5) of the Thiadiazole compound with two groups of thiol (SH) this will give a more power to the compound with a wide range of uses.2,5- disubstituted-1, 3, 4- thiadiazole derivative has biological activities including anticancer [2] antifungal [3] anti-tubercular [4] and anti-inflammatory [5]. Schiff bases are used in a wide range of applications, in biological field [6], industrial applications such as anticorrosion material for steel and alloys, photo stabilizers for poly ethylene, and the methylolic derivatives of phenolic. Schiff bases are used in the production of industrial polymers, such as PVC [7]. Epoxy derivatives are poly ethers contain an epoxy groups at the end of the chain, known as oxiranes [8].These resins undergo polymerization reactions through their ring opening and their participation in a process known industrially as"curing", using hardeners such as the amine compounds.Epoxy resins are used in adhesives, coatings and composite materials [9,10]. The main problem of the epoxy resin is with the passage of time suffered from break covalent bonds for epoxy resins, by sun light, therefore the addition of additives inorganic like TiO 2 and Zinc oxide to
Show more

14 Read more

Synthesis, Characterization and Cytotoxic Activity of some new 1,2,3-Triazole, Oxadiazole and Aza- β-lactam Derivatives

Synthesis, Characterization and Cytotoxic Activity of some new 1,2,3-Triazole, Oxadiazole and Aza- β-lactam Derivatives

Compound (1a) (0.5 gm, 0.002 mole), with (0.002 mole) of aniline derivatives such as (p-toluidine, o-nitroaniline and m-nitroaniline) in 20 ml POCl 3 was refluxed 4 hours. Then the mixture was Concentrated and poured on crushed ice with stirring for giving a solid mass. The product was filtered and dried to give compounds (8a-c). o-[(N-Propargyl)sulfamoyl]-N-(p-tolyl)benzamide (8a):

11 Read more

Synthesis and characterization some flavonoids derivatives

Synthesis and characterization some flavonoids derivatives

In continuation of our ongoing research in the area of antioxidant compounds, we have synthesized 3’,4’,5,7-tetrahydroxyflavanone (39). The synthesis of 3’,4’,5,7- tetrahydroxyflavanone (39) was accomplished starting from 2,4,6- trihydroxyacetophenone (31) as shown in Scheme 1.2. To prepare the desired compounds in high yields, the hydroxyl groups in the starting acetophenone were protected as the MOM-ether derivatives in a step-wise manner with methoxymethyl (MOM) chloride. Regioselective methoxymethylation of the 2- and 4-hydroxyl groups was achieved with the use of the strong base dimethylaminopyridine (DMAP) to give the bis-MOM ether, 2-hydroxy-4,6-bis(methoxymethyloxy)-acetophenone (35). Compound (35) was achieved as brown liquid.
Show more

29 Read more

Synthesis And Characterization Of Some Imidazole Derivatives

Synthesis And Characterization Of Some Imidazole Derivatives

A 0.01 mol of oxazolone (V)and 2,4 –dinitrophenylhydrazine ( 0.015 mol) reflux for 1ohrs in a present of dry pyridine , after refluxing complete then reaction mass is cooled and the r[r]

9 Read more

SYNTHESIS, CHARACTERIZATION, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY EVALUATION OF SOME SUBSTITUTED PYRAZOLE DERIVATIVES

SYNTHESIS, CHARACTERIZATION, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY EVALUATION OF SOME SUBSTITUTED PYRAZOLE DERIVATIVES

An equal amount of methanol and DPPH was added and used as a control. Ascorbic acid was used as a standard for comparison, i.e., 6 mg of ascorbic acid was dissolved in 10 ml methanol from the stock solution various dilutions (10, 20, 40, 80, 160, 320 µg/ml) were prepared. After incubation for 20minutes in the dark, absorbance was recorded at 517 nm. The graph was plotted by taking concentration (μg/ml) on x-axis and percentage scavenged/ inhibition on the y-axis. % scavenging activity was calculated using the formula:
Show more

8 Read more

Synthesis, Characterization with Studing Anti Convulsant Activity of
Some New Resins by Free Radical Polymerization Starting from
Chalcone Derivatives

Synthesis, Characterization with Studing Anti Convulsant Activity of Some New Resins by Free Radical Polymerization Starting from Chalcone Derivatives

tyrosin as and inhibition of aldose reductase activitys (Zhuang et al., 2017), the discovery of derivatives was also based on the rational considerations of pathophysiological mechanism of epileptic syndrome. Hence, the endeavor of the century is to develop antiepileptic drugs with 100% efficiency, safety and tolerability.

10 Read more

Synthesis and characterization of some new pyrazolines derivatives and their biological activity

Synthesis and characterization of some new pyrazolines derivatives and their biological activity

Chalcones( Benzalacetophenones ) are useful synthons [5-7] in the synthesis of alarge number of bioactive molecules , such as pyrazolines [8] and isoxazoles that are well known nitrogen containing heterocyclic compounds [9-15]. The discovery of this class of compounds provides an outstanding case history of modern drug development and also emphasizes the unpredictability of biological activity from structure modification of a prototype drug [16, 17] molecule. The Benzalacetophenone were synthesized by the Claisen – Schmidt condensation reaction and the prazoles derivatives have been synthesized by the treatment of the appropriate chalcones ( 1-VI ) with hydrazinehydrate, phenylhydrazine, semicarbazide, thiosemicarbazide, 2,4-dinitrophenylhydrazine and 4- phenylthiosemicarbazide in catalytic amount of sulpharic acid in ethanol.
Show more

14 Read more

Synthesis, characterization and pharmacological activity of some new phthalimide derivatives

Synthesis, characterization and pharmacological activity of some new phthalimide derivatives

All described, new phthilimido derivatives 2-7, were evaluated in vivo for analgesic activity by using standard experimental models. The evaluation of analgesic activity was done by acetic acid inducer pain and hot plate methods, the reaction time is noted as therapeutic end point. From the fig.1and 2, among all the synthesized compounds 2-7 at dose of 50 mg/kg showed central analgesic activity by increasing the reaction time and peripheral analgesic activity by decreasing number of writhing. This suggested that the best analgesic activity was observed for the compound 2-(hydroxyethyl) isoindoline-1,3-dione 2 , 4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]-4- methyl morpholin-4-ium iodide 5 and 5-amino-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-oxopentanoic acid 7 compared with control group. Table. 2 and 3, fig.1 and 2.
Show more

5 Read more

Synthesis, Characterization & Antimicrobial Activity of some new Dihydropyrimidinethione Derivatives

Synthesis, Characterization & Antimicrobial Activity of some new Dihydropyrimidinethione Derivatives

Thiopyrimidinone play a vital role owing to their range of biological and physiological activities. In the light of these biological activities and variety of industrial applications, some new 4-Aryl-6-isopropyl-5-[N-(3-nitrophenyl)amino carbonyl]-3,4-dihydro pyrimidine-2(1H)-thione of type (2a-l) have been prepared by the cyclocondensation of 2-Arylidene-4-methyl-N-(3-nitrophenyl)-3- oxopentanamide derivatives of type (1a-l) with in presence of potassium bicarbonate. The formulas of the selected compounds were confirmed by the elemental analysis and their structures were determined by IR ,1 H-NMR , and mass spectral data.
Show more

7 Read more

Novel synthesis and spectral characterization of some new substituted pyrazolones and isoxazolone

Novel synthesis and spectral characterization of some new substituted pyrazolones and isoxazolone

dimethyl formamide and refluxed for about 45-60 minutes, after that ethanol (20 ml) was added to it , the filtrate was concentrated over water-bath , hydrazine hydrate 99% with ethanol (20 ml) was added to it , the solid thus obtained, after some time recrystallised with absolute ethanol and was identified malon (R) anilic acid hydrazide (2a-2k). General procedure for the synthesis of 4(2- methoxy-5-methyl)-phenyl hydrazono-N I (R)

5 Read more

Synthesis, characterization and antimicrobial activity of some novel hydrazone derivatives of anacardic acid

Synthesis, characterization and antimicrobial activity of some novel hydrazone derivatives of anacardic acid

To a stirred suspension of 2-hydroxy-6-pentadecylbenzoic acid 2 in methanol, taken in a sealed tube was added Amberlyst -15 (20% w/w) and heated to reflux for 24 h. After completion of the reaction (monitored by T.L.C), the reaction contents were filtered and the filtrate was evaporated under reduced pressure to obtain methyl 2-hydroxy-6- pentadecylbenzoate 3 as a pale yellow liquid. The crude compound was taken to next step without further purification. Yield: 1.45 g, 70%; IR (KBr): 3419, 3066, 2978, 2951, 2915, 2851, 2643, 1942, 1665, 1606, 1578, 1472, 1448, 1336, 1315, 1296, 1250, 1236, 1214, 1203, 1163, 1121, 1106, 1067, 1019, 987, 971, 945, 880, 841, 817, 748, 710, 646, 591, 542; cm -1 ; 1 H NMR (400 MHz, DMSO-d 6 ) δ : 9.79 (s, 1H, -OH), 7.14 (t, J = 8.0 Hz, 1H,
Show more

8 Read more

Synthesis and Characterization of Some Tetrazole Derivatives from 5-Amino Salicylic Acid

Synthesis and Characterization of Some Tetrazole Derivatives from 5-Amino Salicylic Acid

The Salicylic acid is one of the naturally extracted from willow bark, and therefore is called Willow Acid. It belongs to the Phenol family, and is largely common in the manufacturing of drugs that are used as painkillers and antipyretics that are associated with childbirth[1-3]. As for the 5-Amino Salicylic acid, it is one of the components of organic compounds which possess a biological effect against numerous types of Bacteria [4-5]. However, the Azo compounds, which include the effective group (N=N) discovered by Griess, Johann Peter in 1860, they enter a wide variety of industries such as Dyestuffs industry, antibiotics, Colon drugs, and Cosmetics [6-9].
Show more

8 Read more

Synthesis and Characterization of Some New Substituted Azo-Coumarin and Schiff’s Bases

Synthesis and Characterization of Some New Substituted Azo-Coumarin and Schiff’s Bases

A mixture of 2-hydroxy-5(2-methoxy-5- methyl) phenyl azo (1a;0.001 mole ) and N(R)- phenyl malon-anilic acid (2a-2j ; 0.001 mole) , with a trace of pyridine was added to it , then the reaction mixture was heated for 4-hours in an oil-bath maintaining the temperature 104 o to 112 o , the

5 Read more

SYNTHESIS AND CHARACTERIZATION OF SOME NEW 4-SUBSTITUTED-6-(p-AMINOPHENYL)-2-AMINOPYRIDINE-3-CARBONITRILE DERIVATIVES

SYNTHESIS AND CHARACTERIZATION OF SOME NEW 4-SUBSTITUTED-6-(p-AMINOPHENYL)-2-AMINOPYRIDINE-3-CARBONITRILE DERIVATIVES

In conclusion, we have developed an efficient method for the direct preparation of 4-Substituted-6- (p-aminophenyl)-2-aminopyridine-3-carbonitrile derivatives using benzene as solvent in good yields & purity from the readily available starting materials.

5 Read more

Synthesis and Characterization of Some New Cationic Derivatives of Biological Interest

Synthesis and Characterization of Some New Cationic Derivatives of Biological Interest

The surface activities of these amphiphiles were measured, including surface tension γ, critical micelle concentration CMC, effectiveness cmc, efficiency PC20, maximum surface excess Γm[r]

7 Read more

Synthesis and characterization of some new thioxanthone derivatives

Synthesis and characterization of some new thioxanthone derivatives

Preparation of a series of compound 2-bromo thioxanthone by Schiff base reaction : A mixture of 2-bromr- 9H-thioxanthen-9-one(0.6mg ,0.2mmol) and concentrated amine compound in absolut ethanol (15ml) containing glacial acetic acid (5 drops ) was reflux for 8- 10h. The progress of reaction was monitored by TLC . After the completion of reaction ,the reaction mixture was allowed to reach ambient temperature and then the precipitate formed was filtered , dried and from recrystallization by ethanol to get pure powder.

9 Read more

Show all 10000 documents...

Related subjects