[PDF] Top 20 Synthesis, Characterization and In Vitro Antitumor Evaluation of New Pyrazolo[3,4 d]Pyrimidine Derivatives
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Synthesis, Characterization and In Vitro Antitumor Evaluation of New Pyrazolo[3,4 d]Pyrimidine Derivatives
... of new selective, potent and safe anti- tumor agents is a must. Pyrazolo[3,4- d ]pyrimidine nucleus is the bioisostere of purine [4] [5], which exhibits promising activity as ... See full document
18
Design, synthesis, docking, and antimicrobial evaluation of some novel pyrazolo[1,5-<em>a</em>]pyrimidines and their corresponding cycloalkane ring-fused derivatives as purine analogs
... antimicrobial resistance occurs naturally and spontaneously over time, usually through genetic changes. Antimicrobial resistance is naturally generated by natural selection from random mutations. When the new gene ... See full document
14
PEG 400: prompted eco friendly synthesis of some novel pyrazolo [1, 5 a] pyrimidine derivatives and their in vitro antimicrobial evaluation
... Pyrazolopyrimidine derivatives exhibit diversified pharmacological activities like CNS depressant [6], neuroleptic [7], tuberclostic [8], antihypertensive [9], analgesic [10] and antimicrobial activity [11] ... See full document
9
Reviewing of Synthesis and Computational Studies of Pyrazolo Pyrimidine Derivatives
... Heterocyclic pyrimidine nucleus includes four carbon and two nitrogen atoms and is pharmacologically in active; however, its synthetic derivatives have important roles in pharmaceutical applications ... See full document
50
Synthesis, characterization and pharmacological evaluation of pyrimidine and its derivatives for their anticancer activity.
... (1)-substituted pyrazolo [3,4-d] pyrimidine MSK-039 was discovered as a low-micromolar inhibitor of EGFR tyrosine kinase ...a new avenue toward the optimization of novel chemical entities to ... See full document
176
Synthesis, Characterization and Antitumor Activity of Some Novel Pyrimidine Sulfonamide Derivatives
... is synthesis of pyrimidine-5-sulfonamides ...and 3-bromopropanoic acid yielded the condensed pyrimidine derivatives incorporating sulfonamide moiety such as: imidazopyrimidine 3a,b, ... See full document
9
Acid Catalyzed One Pot Synthesis of Nitro Substituted Pyrazolo [1,5-a] Pyrimidine Derivatives Paresh Ladwa 1, Dr. Jayesh J. Modha1
... some new highly functionalized pyrazolopyrimidine ...the synthesis of pyrazolopyrimidine derivatives such as very well- known method for this is one pot synthesis of ethylacetoacetate, ... See full document
8
Synthesis and antibacterial evaluation of new azo-pyrimidine derivatives
... To detect the mechanism of action of the newly synthesized target azo-compounds, these compounds were subjected to a molecular docking study using Glucosamine-6- phosphate synthase enzyme. This work was performed using ... See full document
8
Doxorubicin loaded cholic acid polyethyleneimine micelles for targeted delivery of antitumor drugs: synthesis, characterization, and evaluation of their in vitro cytotoxicity
... Preparation of the doxorubicin-loaded CA-PEI micelles Doxorubicin hydrochloride (2.5 mg) was dissolved in 2 mL chloroform and mixed with 2 μL of triethylamine. CA-PEI copolymers of different molar ratios (1:1, 1:2, ... See full document
9
Synthesis, characterization and In vitro antimicrobial evaluation of novel pyrazolothiazol-4(5H)-one derivatives
... in vitro antimicrobial activity of newly synthesized compounds (3a‑3j) was determined by tube dilution ...in vitro antifungal activity against Aspergillus niger ATCC 9029 and Candida albicans ATCC ... See full document
5
Synthesis and characterization of some new 3, 5 disubstituted pyrimidine and thiopyrimidine derivatives
... 1-(3-chloro-6-hydroxyphenyl)-ethanone (1a) (0.01 mol) dissolved in ethanol (40 ml) and 4-methoxybenzaldehyde (0.01 mol) was added with constant stirring at room temperature. Then NaOH solution (40%) was ... See full document
5
SYNTHESIS OF NOVEL PYRIMIDINE AND FUSED PYRIMIDINE DERIVATIVES AND THEIR IN VITRO ANTIMICROBIAL AND CYTOTOXIC EVALUATION
... some new pyrimidine and fused pyrimidine derivatives were synthesized and elucidated by spectral data and elemental ...the new compounds were investigated for their in vitro ... See full document
24
NEW PYRIMIDINE AND FUSED PYRIMIDINE DERIVATIVES: SYNTHESIS AND ANTI HEPATITIS A VIRUS (HAV) EVALUATION
... fused pyrimidine derivatives 5–14 were prepared starting with compound ...Ethyl 4-(2,5- dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 2 was used for the preparation of ... See full document
11
SYNTHESIS OF 5ARYLIDINE2(3, 4, 5TRIMETHOXYPHENYL)3(4PHENYLTHIAZOL2YL) THIAZOLIDIN4ONE DERIVATIVES AS A NOVEL CLASS OF ANTIMICROBIAL AGENTS
... the synthesis and in vitro antimicrobial evaluation of 5‐arylidine derivatives of 2‐(3, 4, 5‐trimethoxyphenyl)‐3‐(4‐ phenylthiazol‐2‐yl) thiazolidin‐4‐one ... See full document
5
Synthesis, Cytotoxicity, Xanthine Oxidase Inhibition, Antioxidant of New Pyrazolo{3,4 d}Pyrimidine Derivatives
... Viable cells are able to reduce the yellow MTT under tetrazolium ring cleavage to a water- insoluble purple-blue formation which precipitates in the cellular cytosol and can be dissolved after cell lysis, whereas cells ... See full document
7
Synthesis, reactivity and antitumor activity of some new pyrazolo[3,4-d] pyrimidine and their triazole derivatives
... properties. Pyrazolo[3, 4 - d] pyrimidine derivatives bearing a fluorinated heterocyclic moiety, particularly 8-trifluoromethyl quinoline, find much importance in the ... See full document
10
Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives
... the synthesis of hitherto unknown fused ...derivative 3 on the basis of ana- lytical and spectral data (Scheme ...of 3 from the reaction of 2 with malononitrile is believed to be formed via initial ... See full document
14
H NMR, 13 C NMR, mass spectra and elemental analysis. All the
... the synthesis of a novel series of pyrazolo[3,4-d]pyrimidine derivatives by incorporating the phenothiazine and pyrazolo[3,4- d]pyrimidine in a single molecular ... See full document
6
“Synthesis and Antitumor Activity of Novel Pyrazolo[3,4-D]Pyrimidine and their Tricyclic Derivatives” by Phoebe, F. Lamie, Egypt.
... radiotherapy. 4 Now, cancer chemotherapy is entering a new era by using molecular target therapeutics (highly selective agents which target specific molecular targets that are abnormal or over expressed in ... See full document
7
Design, Synthesis and Antimicrobial Evaluation of Indolyl Pyrimidine Derivatives
... Substituted pyrimidine plays very important role in medicinal chemistry for theirtherapeutic action ...a pyrimidine base in thymine, cytosine and uracil, which are constituents of nucleic acids [2] DNA and ... See full document
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