[PDF] Top 20 Synthesis of highly substituted 2-spiropiperidines
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Synthesis of highly substituted 2-spiropiperidines
... histrionicotoxin, 2 nankakurine, 3 pinnaic acid, 4 ...their synthesis have been ...the synthesis of ...of 2-spiropiperidines rely either on the use of toxic organotin-reagents, 7 ... See full document
14
Feierfeil, Johannes (2017): De Novo synthesis of arenes and heteroarenes. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... organic synthesis and it is also present in various biologically active compounds and ...the synthesis of substituted benzoates via a cyclopropanation-ring-opening aromatization ...a ... See full document
346
APPLICATION OF DESYMMETRIZATION TOWARDS THE SYNTHESIS OF NATURAL PRODUCTS: SALINIKETALS,VENTURICIDIN-X AND EMERICELLAMIDE-B
... The synthesis was commenced from aldehyde 29 whose synthesis has already been disclosed in the previous ...The highly substituted aldehyde 29 under Grignard reaction condition with ethyl ... See full document
16
Highly Efficient Synthesis of 2-substituted 4(3H)-quinozolinones Derivatives Using Boron Tribromide as a Catalyst
... Spectrometer using TMS as internal standard. The mass spectra were obtained on a JEOL 5x102/DA-6000 mass spectrometer. The IR spectra were recorded on Perkin-Elmer spectrum RX FT-IR System using KBr pellets. All the ... See full document
8
“C. Limon Catalyzed Heterocyclisation: Microwave Assisted Rapid One Step Synthesis of Substituted 2-aryl benzoxazoles” by Bhagyashri. A. Lole, Pravina B. Piste, India.
... and highly efficient acid catalyst offers a convenient, nontoxic, inexpensive reaction medium for the synthesis of 2-aryl benzoxazoles under microwave irradiation condition were ...for ... See full document
5
Synthesis, characterization of 2-substituted benzimidazole derivatives and evaluation of antimicrobial activity
... are substituted in 1-position by an alkyl, aryl, acyl or amino group are not highly ...as 2- benzoylbenzimidazole (1) occupy an intermediate ... See full document
5
Straightforward synthesis of 2 and 2,8 substituted tetracenes
... often highly crystalline and frequently attained as glinting colourless analytically pure needles from simple hot MeOH:EtOAc ...PhCH 2 ZnCl in 87% ... See full document
8
MICROWAVE MEDIATED SYNTHESIS OF PHARMACOLOGICAL ACTIVE SUBSTITUTED DERIVATIVES OF 2 (4/ PHENOTHIAZINYL PYRAZOLYL) PYRROLES
... We highly thankful to Dr. R. S. Bobhote, principal, VVACSC, Samudrapur for providing necessary facility for the complexion of this research work. The authors are also thankful to the Head, Department of ... See full document
10
SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME SUBSTITUTED AZETIDINONE DERIVATIVES
... The anticonvulsant activity of 3-Chloro-4- substitutedphenyl-l-[{4-(1-naphthyl)-1, 3- thiazol-2-yl} amino] azetidin-2-ones (A1-A15) by MES method revealed that two compounds namely, A4 (Ar = 3-chlorophenyl) ... See full document
6
Strategies for the Synthesis of Spiropiperidines - A Review of the Last 10 Years
... vectors. 2 Owing to the frequency of nitrogen containing heterocycles in drug discovery and the growing desire to explore three- dimensional space, aza-spirocycles are fast becoming highly desirable targets ... See full document
16
Synthesis and thermoelectric properties of 2 and 2,8 substituted tetrathiotetracenes
... carried out quickly and with only small amounts of sample (10-20 mg). The most important conclusion of our work is that 2,8-disubstituted TTT molecules (1e-h) show significantly improved performance in key thermoelectric ... See full document
11
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 6-SUBSTITUTED 2-AMINOBENZOTHIAZOLES
... a substituted aromatic aldehyde, carboxylic acid, acyl chloride or ...many substituted 2-arylbenzothiazoles due to the difficulties encountered in the synthesis of the readily oxidisable ... See full document
7
Diastereoselective synthesis of highly substituted, amino and pyrrolidino tetrahydrofurans as lead like molecular scaffolds
... of highly substituted tetrahydrofurans (THFs), decorated with modifiable 2-aryl, 3- carboxy and 4-amino substituents, has been prepared for biological evaluation within the European Lead ... See full document
19
Stereoselective synthesis of highly substituted tetrahydrofurans by diverted carbene O–H insertion reaction
... of highly substituted tetrahydrofurans was accessible in modest to excellent yield, accompanied in some cases by small amounts of the corresponding O–H insertion product (Schemes 3 and ...nitro ... See full document
6
Synthesis of highly substituted allenylsilanes by alkylidenation of silylketenes
... more substituted ylide 4 were significantly slower than those with the parent ylide 5 (compare reaction temperatures and times, entries 1, 3 and 5 versus entries 2, 4 and ...aromatic substituted ... See full document
5
Rapid, Catalyst-free and Diastereoselective Synthesis of 3-hydroxy-2-oxindole Scaffolds under Microwave Irradiation in Aqueous Reaction Media
... the highly diastereoselective synthesis of 3-thiazolidinedione subsitituted, 3-hydroxy-2-oxindole framework under aqueous ...Table 2). Di-substituted isatin like 4,7-dichloro isatin ... See full document
10
A Two-Step Synthesis of 2-Spiropiperidines
... two-step synthesis of 2-spiropiperidines has been ...generate 2-spiropiperidines in good to excellent yields. The 2-spiropiperidines formed occupy an under-explored region ... See full document
5
Synthesis and antimicrobial activity of some new 2,3 disubstituted quinazoline 4(3H) ones derivatives
... All the synthesized compounds were tested for their in vitro antimicrobial activity against the Gram-positive bacteria, Staphylococcus aureus and Bacillus subtilis, the Gram negative bacteria, Escherichia coli and ... See full document
5
Synthesis and bioassay of 2 substituted 1, 3, 2 oxazaphosphole 2 ones
... All the compounds (3a-j) were screened for their antibacterial activity against Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli and Bacillus subtils. The in vitro anti bacterial activity of the compounds ... See full document
7
QSAR analysis and validation studies on substituted spiropiperidines as GlyT1 inhibitors
... particular, N-methyl-D-aspartate (NMDA) receptor activation, produces both anti-psychotic and cognitive enhancing effects, thus constituting a potential therapeutic target for the treatment of schizophrenia, psychoses ... See full document
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