[PDF] Top 20 Synthesis of nitrogen containing heterocycles via radical cyclisation
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Synthesis of nitrogen containing heterocycles via radical cyclisation
... The 2-methyl and 2-phenyl substituents were selected to provide both a contrast in steric bulk and variation in the degree o f hybridisation of the carbon attached to the chain. The corresponding 3-methyl and phenyl ... See full document
278
Facile synthesis of fused nitrogen containing heterocycles as anticancer agents
... derivatives via simple pyrazole (5-methyl-2,4-dihydro-3H-pyrazol-3-one) as starting ...of Nitrogen containing heterocycles and have evaluated their efficiency as an antihepatocellular ... See full document
18
Polyethylene glycol embedded tribromide as an efficient and reusable catalyst for the library synthesis of nitrogen containing heterocycles
... library synthesis of nitrogen containing heterocyclic compounds via multicomponent coupling ...facile synthesis, low cost, recycling ability and high product ... See full document
12
Synthesis and antibacterial and antifungal studies of novel nitrogen containing heterocycles from 5-Ethylpyridin-2-ethanol
... 4n containing 2,4-Cl, 4-OH, phenyl, 4-F, 3-OCH 3 and 3-F at 200- 500 g/ml; 5o having 3,4-F at 200 g/ml against ...6c containing 2,4-Cl displayed more at 100 g/ml against ... See full document
8
Highly efficient synthesis of heterocycles via 5 endo radical cyclisation
... l3 , 22 Giese found that the rate of addition of nucleophilic radicals to alkenes increases with the electron withdrawing ability of substituents on the alkene partner and with the numbe[r] ... See full document
293
Synthesis of nitrogen heterocycles via amidyl radical cyclisations
... amidyl radical cyclisations and the effect of the nitrogen substituent on the ...amidyl radical cyclisations are likely to be much flatter than the hex-5-enyl analogues due to the carbonyl group and ... See full document
257
New approaches to nitrogen heterocycles via radical cyclisations
... the cyclisation of ester 79 with 5 mol% Cu(85)Cl in toluene afforded lactone 83 in 95% conversion in 48 h via an 8- endo trig cyclisation along with the benzannulated 80 as a minor ... See full document
293
A radical approach to nitrogen heterocycles
... metal-catalysed radical cyclisations have received considerable attention in organic ...transfer cyclisation of (o-haloolefms is currently emerging as a valuable tool for the construction o f carbo- and ... See full document
265
Total Synthesis of the Synoxazolidinone Family of Natural Products and Novel Approaches for the Construction of Nitrogen and Oxygen Containing Heterocycles.
... the synthesis of β,γ-unsaturated primary α-keto amides using the magnesium nitride/water system as an ammonia source, neither T3P nor pyBop coupling agents gave desired phenylpyruvamide 4-11 (Entries 1 and 2, ... See full document
303
2-Iodoisatogens: Versatile Intermediates for the Synthesis of Nitrogen Heterocycles
... At the outset of the project, we had the opportunity to focus our studies on the cyclisation of bromo- or iodo-ethynyl 2- nitrobenzenes in an effort to generate the corresponding 2- haloisatogens. Looking forward ... See full document
5
The Synthesis and Biological Examination of 5-Membered Nitrogen-Based Heterocycles.
... with the tested 2-AI served as a control. After sitting at room temperature for 30 minutes, 1 mL of each sample was transferred to a culture tube, and oxacillin sodium salt was added from a 128 mg mL-1 water stock ... See full document
262
SYNTHESIS AND BIOEVALUATION OF N, O CONTAINING HETEROCYCLES AND NEW METHODOLOGIES
... Imidazo[1,2-a]pyrazine is a fused ring system of six and five membered rings with nitrogen bridgehead. Imidazo[1,2-a]pyarazines are well known biologically active molecules which have shown antibacterial, ... See full document
17
Synthesis of novel Sultams containing azetidinone heterocycles
... of nitrogen until complete saturation, noted by a permanent pale green colouration (1 ...with nitrogen, and dry diethyl ether (60 mL) was added to the mixture, which was stirred for a further 1 hour at room ... See full document
7
Synthesis and Antibacterial Activity of Bis-heterocycles Containing Pyrimidine and Morpholine
... spectrum of 2 showed resonances at δ 10.9 as a singlet for two protons corresponding to hydroxyl protons, at δ 9.83 as a singlet for two protons of formyl groups. The mass spectrum of 2 showed a signal at m/z 256 ... See full document
11
Synthesis of novel Sultams containing thiazolidin 4 one heterocycles
... of nitrogen until complete saturation, noted by a permanent pale green colouration (1 ...with nitrogen, and dry diethyl ether (60 mL) was added to the mixture, which was stirred for a further 1 hour at room ... See full document
7
Radical aromatic cyclisation and substitution reactions
... by nitrogen to carbon aryl ...of radical 212 by homolysis of the corresponding C-Br bond using tributyltin hydride and AIBN led to a 1,5-ipso attack to furnish the spirocyclohexadienyl radical ... See full document
275
Synthesis and evaluation of some nitrogen heterocycles as antimalarials
... The nitro compounds (VI.I) were subjected to catalytic reduction with hydrogen over Raney nickel in ethanolic ammonia at atmospheric pressure and room temperature to afford the corresponding amines (VI.3). These were ... See full document
258
SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME NEW HETEROCYCLES CONTAINING NITROGEN AND SULPHUR
... Cup-plate Method: This method depends on the diffusion of an antibacterial agent from a cavity through the solidified agar layer in a petridish to an extent such that growth of the added microorganisms is prevented ... See full document
13
Copper (I) mediated radical cyclisation novel approaches to nitrogen heterocycles
... Tandem radical cyclisation reactions have been catalysed using copper I chlorideibipy.19 For example, reaction of trichloroamide 38 with this catalyst at 40°C gave the diastereomeric bic[r] ... See full document
347
Fused Heterocyclic Nitrogen Systems Containing Phosphorus Atom
... with primary aromatic amines afforded the Betaine 37 which under treatment with ethanol in the presence of tetrafluoro boric acid by stirring for 7 hours, resulted the 1,3-thiadiazetidines 38 via carbodiimide ... See full document
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