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[PDF] Top 20 Targeting cancer stem cells: emerging role of Nanog transcription factor

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Targeting cancer stem cells: emerging role of Nanog transcription factor

Targeting cancer stem cells: emerging role of Nanog transcription factor

... Activating Nanog at an inappropriate time would cause CSC rather than ESC-like ...repress Nanog during the differentiation process in mouse pluripotent stem cells results in tumor ...Moreover, ... See full document

14

Original Article Expression and promoter activity of homeodomain factor Nanog in pancreatic cancer cells

Original Article Expression and promoter activity of homeodomain factor Nanog in pancreatic cancer cells

... Abstract: NANOG is a transcription factor in embryonic stem cells (ESCs) and thought to be a key factor in maintain- ing ...Moreover, Nanog gene expression closely related ... See full document

7

Requirement of the transcription factor YB-1 for maintaining the stemness of cancer stem cells and reverting differentiated cancer cells into cancer stem cells

Requirement of the transcription factor YB-1 for maintaining the stemness of cancer stem cells and reverting differentiated cancer cells into cancer stem cells

... differentiated cancer cells into cancer stem cells, constructs expressing YB-1, SOX2, POU3F2, OCT-4, OLIG1, SALL2, and Bmi-1 were separately transfected into YB-1 knockout melanoma ... See full document

15

Emerging role of lipid metabolism alterations in Cancer stem cells

Emerging role of lipid metabolism alterations in Cancer stem cells

... Cancer cells exhibit a distinct metabolic profile as com- pared to it’s normal ...tumor cells proliferation and inadequate blood vessels formation, tumor microenviroments are characterized by ... See full document

18

NANOG Plays a Hierarchical Role in the Transcription Network Regulating the Pluripotency and Plasticity of Adipose Tissue-Derived Stem Cells (ASCs)

NANOG Plays a Hierarchical Role in the Transcription Network Regulating the Pluripotency and Plasticity of Adipose Tissue-Derived Stem Cells (ASCs)

... of Nanog is capable of maintaining the pluripotency and self-renewing characteristics of ESCs under what normally would be differentiation-inducing culture conditions ...the role of SOX2 seems to be crucial ... See full document

24

Targeting deubiquitinating enzymes in cancer stem cells

Targeting deubiquitinating enzymes in cancer stem cells

... Hypoxia-inducible factor (HIF) tran- scription factors (HIF-1α and HIF-2α) are key mediators in cancer hypoxia response and help maintain multiple CSC population [61, ...these transcription factors ... See full document

6

The role of Nanog expression in tamoxifen-resistant breast cancer cells

The role of Nanog expression in tamoxifen-resistant breast cancer cells

... significant role of cancer stem cells in tumor initiation, proliferation, relapse, and ...metastasis. Nanog is the most important core transcription marker of stem ... See full document

8

Role of SATB2 in human pancreatic cancer: Implications in transformation and a promising biomarker

Role of SATB2 in human pancreatic cancer: Implications in transformation and a promising biomarker

... a transcription factor and chromatin modulator, regulates the expression of genes required for maintaining pluripotency and ...epithelial cells are transformed to cancer cells are not ... See full document

15

Anti-miR-203 suppresses ER-positive breast cancer growth and stemness by targeting SOCS3

Anti-miR-203 suppresses ER-positive breast cancer growth and stemness by targeting SOCS3

... breast cancer cell growth and stemness (Figure ...breast cancer. To our knowledge, this is the first study showing the role of miR-203 in ER-positive breast cancer ... See full document

11

Ovarian cancer: emerging concept on cancer stem cells

Ovarian cancer: emerging concept on cancer stem cells

... ovarian cancer cell lines such as MOVCAR7 and 4306 con- tain candidate cancer stem cells ...ovarian cancer cells have large SP, making them suitable to study ovarian ... See full document

9

Overlapping functions of Krüppel like factor family members: targeting multiple transcription factors to maintain the naïve pluripotency of mouse embryonic stem cells

Overlapping functions of Krüppel like factor family members: targeting multiple transcription factors to maintain the naïve pluripotency of mouse embryonic stem cells

... in stem cell colony formation (Figs 1A and ...pluripotency-associated transcription factors, such as Oct3/ 4, Sox2, Tbx3, Nanog, Esrrb, Gbx2, Nr5a2, Tfcp2l1 and Nr0b1 (Figs 1C and ...associated ... See full document

12

The pluripotency transcription factor Nanog represses glutathione reductase gene expression in mouse embryonic stem cells

The pluripotency transcription factor Nanog represses glutathione reductase gene expression in mouse embryonic stem cells

... Embryonic stem cells (ESCs), which derive from the inner cell mass of blastocysts, possess several systems that secure genomic ...these cells physiologically originate all cell types of the organism, ... See full document

7

Suberoylanilide hydroxamic acid (SAHA) reverses chemoresistance in head and neck cancer cells by targeting cancer stem cells via the downregulation of nanog

Suberoylanilide hydroxamic acid (SAHA) reverses chemoresistance in head and neck cancer cells by targeting cancer stem cells via the downregulation of nanog

... allowing transcription factors and RNA polymerase II ...including transcription factors ...of cancer stem cells by modulating nanog expression [19, ... See full document

13

Melatonin decreases estrogen receptor binding to estrogen response elements sites on the OCT4 gene in human breast cancer stem cells

Melatonin decreases estrogen receptor binding to estrogen response elements sites on the OCT4 gene in human breast cancer stem cells

... Cancer stem cells (CSCs) pose a challenge in cancer treatment, as these cells can drive tumor growth and are resistant to ...in cancer cells, however its action in CSCs is ... See full document

9

Hyaluronan-conjugated liposomes encapsulating gemcitabine for breast cancer stem cells

Hyaluronan-conjugated liposomes encapsulating gemcitabine for breast cancer stem cells

... MCF-7 cells and BCSCs was measured by an MTT assay. The MCF-7 cells and BCSCs were dissoci- ated and plated in a 96-well plate at 2,500 cells/well density in ...permit cells to attach to the ... See full document

13

Role of stem cells in cancer therapy and cancer stem cells: a review

Role of stem cells in cancer therapy and cancer stem cells: a review

... of stem cells as delivery vehicles came from the fact that the tumours, similar to the wounds, send out chemo-attractants such as the vascular endothelial growth factor (VEGF) to recruit MSC to form ... See full document

11

Molecular identification and targeting of colorectal cancer stem cells

Molecular identification and targeting of colorectal cancer stem cells

... these cells to form new tumors. Therefore, the role of CSCs markers in maintaining a stem cell state should be investigated and more functionally important markers should be identified, like CD44, ... See full document

9

Caballero Martínez, Amelia
  

(2019):


	The role of the potassium channels KV1.3 and KCa3.1 in arteriogenic smooth muscle cell proliferation.


Dissertation, LMU München: Medizinische Fakultät

Caballero Martínez, Amelia (2019): The role of the potassium channels KV1.3 and KCa3.1 in arteriogenic smooth muscle cell proliferation. Dissertation, LMU München: Medizinische Fakultät

... Following the obstruction of a feeding artery, a pressure gradient is established between the prestenotic high-pressure bed and the poststenotic low-pressure bed, leading to a rise in blood flow and flow velocity through ... See full document

149

Targeting specificity of dendritic cells on breast cancer stem cells: in vitro and in vivo evaluations

Targeting specificity of dendritic cells on breast cancer stem cells: in vitro and in vivo evaluations

... marrow cells were harvested by flushing the marrow cavities of the femur and tibia bones of male mice with medium under aseptic ...colony-stimulating factor (GM-CSF), and 50 ng/mL IL-4 (Santa Cruz ... See full document

12

The principles that govern transcription factor network functions in stem cells

The principles that govern transcription factor network functions in stem cells

... somatic cells to induced pluripotent stem cells (iPSCs), it is well known that Oct3/4 (Pou5f1) and Sox2 form a heterodimer to recognize the pluripotent stem cell-specific target sites in the ... See full document

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