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[PDF] Top 20 Targeting DNA Repeat Sequences with Py Im Polyamides

Has 10000 "Targeting DNA Repeat Sequences with Py Im Polyamides" found on our website. Below are the top 20 most common "Targeting DNA Repeat Sequences with Py Im Polyamides".

Targeting DNA Repeat Sequences with Py Im Polyamides

Targeting DNA Repeat Sequences with Py Im Polyamides

... of polyamides 1b, 3b, and distamycin D control were incubated in 96 µl of 10 pM unmethylated lambdaphage DNA (Promega) and 1X NEB2 buffer (New England Biolabs) in DEPC-treated water (USB) for 12 hours at 25 ... See full document

143

Synthesis and Structural Studies of Cyclic Py Im Polyamides

Synthesis and Structural Studies of Cyclic Py Im Polyamides

... of polyamides to bind ...oligomers targeting the DNA sequence 5'-WGGGGW-3' were shown to inhibit DNA binding of the Nf-κB transcription factor by EMSA gel ...of polyamides using ... See full document

363

Preclinical Study of DNA-Recognized Peptide Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Progressive Renal Diseases in Common Marmoset

Preclinical Study of DNA-Recognized Peptide Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Progressive Renal Diseases in Common Marmoset

... (PI) polyamides are novel gene silencers that strongly bind the promoter region of target genes in a sequence-specific manner to inhibit gene ...polyamide targeting human TGF-b1 (hTGF-b1). To develop PI ... See full document

25

Programming Protein Patterns on DNA Nanostructures with Pyrrole Imidazole Polyamides

Programming Protein Patterns on DNA Nanostructures with Pyrrole Imidazole Polyamides

... for targeting extended DNA ...linked polyamides can target sequences up to 10 bp in ...longer sequences to prevent binding at other undesired locations in the ...eight-ring ... See full document

131

Activity of Py Im Polyamides in Anti Androgen Resistant Prostate Cancer Models

Activity of Py Im Polyamides in Anti Androgen Resistant Prostate Cancer Models

... (Py-Im) polyamides are non-covalent, sequence specific DNA binders that can alter DNA ...the DNA minor groove, the molecules cause a 4 angstrom widening of the minor groove walls ... See full document

114

Shape selective recognition of the DNA minor groove by hairpin polyamides

Shape selective recognition of the DNA minor groove by hairpin polyamides

... predetermined DNA sequences with affinities and specificities rivaling naturally occurring ...of DNA sequences that can be specifically targeted with ...groove-binding polyamides as ... See full document

18

Synthesis and Biological Studies of DNA binding Cyclic Py Im Polyamides

Synthesis and Biological Studies of DNA binding Cyclic Py Im Polyamides

... Pyrrole-imidazole polyamides are a class of synthetic ligands that can be programmed to bind the minor groove of specific DNA ...whereas Py/Py pairs are specific for both T·A and ...hairpin ... See full document

176

Biological Activity of a Py-Im Polyamide Androgen Receptor Antagonist

Biological Activity of a Py-Im Polyamide Androgen Receptor Antagonist

... for polyamides as transcriptional regulators was first established with a polyamide targeted to the DNA response elements of the major groove-binding transcription factor HIF1α ...The DNA binding ... See full document

141

Structural Variations on the Turn Unit of DNA Binding Hairpin Py Im Polyamides

Structural Variations on the Turn Unit of DNA Binding Hairpin Py Im Polyamides

... to DNA sequences 5’-TGTTCA-3’ and 5’- ...of Im/Py pairs in the polyamides, significantly diminished DNA duplex stabilizations have been ...to DNA sequence 5’-TGGGCA-3’ ... See full document

209

Endogenous Gene Regulation by DNA Binding Polyamides

Endogenous Gene Regulation by DNA Binding Polyamides

... medicine. Polyamides containing N-methylimidazole (Im) and N-methylpyrrole (Py) comprise a class of programmable DNA-binding ligands capable of binding to a broad repertoire of DNA ... See full document

11

A Centromeric Tandem Repeat Family Originating From a Part of Ty3/gypsy-Retroelement in Wheat and Its Relatives

A Centromeric Tandem Repeat Family Originating From a Part of Ty3/gypsy-Retroelement in Wheat and Its Relatives

... 301-bp repeat containing 16 copies of a CAA microsatellite was ...the DNA sequence of this 250-bp repeat showed no notable homology in the databases, the flanking or intervening sequences ... See full document

8

Influence of sequences in the long terminal repeat and flanking cell DNA on polyadenylation of retroviral transcripts.

Influence of sequences in the long terminal repeat and flanking cell DNA on polyadenylation of retroviral transcripts.

... Nevertheless, most or all individual proviruses seem to be capable of giving rise to readthrough transcripts, at levels which probably reflect the inefficiency of viral polyadenylation s[r] ... See full document

5

Detection of DNA by sequence specific fluorescent polyamides

Detection of DNA by sequence specific fluorescent polyamides

... Research in the laboratories of Professor Peter B. Dervan has led to the development of minor groove binding distamycin derivatives that can recognize a large number of predetermined DNA sequences with ... See full document

9

Distribution of new satellites and simple sequence repeats in annual and perennial Glycine species

Distribution of new satellites and simple sequence repeats in annual and perennial Glycine species

... these repeat sequences and rDNA loci may be due to (1) the three repeat sequences having existed in the rDNA of the genome of their common earlier ancestor, (2) all having expanded and ... See full document

11

E1A represses wild-type and F9-selected polyomavirus DNA replication by a mechanism not requiring depression of large tumor antigen transcription.

E1A represses wild-type and F9-selected polyomavirus DNA replication by a mechanism not requiring depression of large tumor antigen transcription.

... Adenovirus ElA proteins repress transcriptional activation of various enhancers, including those of Py, and can stimulate DNA replication in quiescent cells, but ElA effects on Py DNA re[r] ... See full document

8

Formation of Large Palindromic DNA by Homologous Recombination of Short Inverted Repeat Sequences in Saccharomyces cerevisiae

Formation of Large Palindromic DNA by Homologous Recombination of Short Inverted Repeat Sequences in Saccharomyces cerevisiae

... Large DNA palindromes form sporadically in many eukaryotic and prokaryotic genomes and are often associated with amplified ...inverted repeat sequence near a DNA double- strand break has been ... See full document

11

Murine polyomavirus and simian virus 40 large T antigens produce different structural alterations in viral origin DNA.

Murine polyomavirus and simian virus 40 large T antigens produce different structural alterations in viral origin DNA.

... within Py viral DNA has three high- affinity binding sites, A, B, and C, containing three, two, and four pentanucleotides, respectively, on the early side of the core ...the Py core ori contains a ... See full document

7

Characterization of a Maize Chromosome 4 Centromeric Sequence: Evidence for an Evolutionary Relationship With the B Chromosome Centromere

Characterization of a Maize Chromosome 4 Centromeric Sequence: Evidence for an Evolutionary Relationship With the B Chromosome Centromere

... non-Cent4 sequences in the BACs would hybridize to other sites within the ge- ...centromeric DNA present, which is 22105, and 22107 appear to contain more complex DNA detectable via FISH, is specific ... See full document

12

Allosteric Inhibition of Zinc Finger Proteins by DNA Binding Polyamides

Allosteric Inhibition of Zinc Finger Proteins by DNA Binding Polyamides

... isotherms represent binding at the match target site in the minor groove, which has the sequence shown in the lower right panel of the figure, and which overlaps [r] ... See full document

153

A cloned polyoma DNA fragment representing the 5' half of the early gene region is oncogenic.

A cloned polyoma DNA fragment representing the 5' half of the early gene region is oncogenic.

... The U peptide has been By using a recombinant plasmid, pPB90, con- identified in the middle T Ag found in Py-6, a taining Py DNA extending clockwise from the Py-transformed mouse cell li[r] ... See full document

9

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