[PDF] Top 20 Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110 inhibition
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Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110 inhibition
... from Cell Signaling Technology (Danvers, ...siRNA, cells were transfected with double stranded control non-targeting or PIM1 or PIM2 targeting RNA oligonucleotides (Santa Cruz Biotechnology, ... See full document
10
Repurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastoma
... the inhibition of cell growth and induction of apoptosis of glioma stem cells (GSCs) using both in vitro and in vivo ...with inhibition of H19 and HMGA2 ...GSCs. Combined ... See full document
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TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2
... tyrosine kinase (RTK)/Ras/ phosphatidylinositol-3-kinase (PI3K) signaling pathways [6, ...identifying glioblastoma patients most likely to respond to drugs targeting these pathways, we ... See full document
10
PI3K/Akt/mTOR and CDK4 combined inhibition enhanced apoptosis of thyroid cancer cell lines
... the cell growth regulation, proliferation, and ...the kinase family of enzyme is divided into three classes as follows: class I, which is activated downstream of cell surface receptors, Class IA ... See full document
11
Interferon-regulatory factor-1 (IRF1) regulates bevacizumab induced autophagy
... Angiogenesis inhibition in vivo leads to tumor tissue hypoxia and nutrient stress, both of which activate ...two glioma cell lines (U87 glioblastoma cells and GSC11 glioma ... See full document
14
Selective migration of neuralized embryonic stem cells to stem cell factor and media conditioned by glioma cell lines
... neural stem/progenitor cells in vitro, and after a freezing brain injury SCF is up-regulated in neurons at the site of ...endothelial cells is increased at the site of injury and that exogenous human ... See full document
8
miR128-1 inhibits the growth of glioblastoma multiforme and glioma stem-like cells via targeting BMI1 and E2F3
... All cells were maintained in 5% CO 2 at 37ºC. The cells were grown and differentiated in serum- free DMEM/F12 medium with 2% B27 (Invitrogen), 10 ng/mL human recombinant leukemia inhibitory factor ... See full document
14
Mitochondrial p32 is upregulated in Myc expressing brain cancers and mediates glutamine addiction
... medulloblastoma tissues was also evident following immunostaining of a medulloblastoma tissue array (Fig. 2A right panel). Similar immunohistochemical analysis was also performed in an array containing glioma ... See full document
14
RNA nanoparticle as a vector for targeted siRNA delivery into glioblastoma mouse model
... pRNA-3WJ-si(Luc) clearly reduced luciferase activity in a concentration dependent manner. At 400 nM, average luciferase activity in U87EGFRvIII-Luc cells incubated with FA-pRNA-3WJ-si(Luc) was decreased about five ... See full document
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microRNA-206 is involved in survival of hypoxia preconditioned mesenchymal stem cells through targeting Pim-1 kinase
... of Pim-1. Luciferase activity assay further confirmed Pim-1 as a putative target of ...that inhibition of miR-206 in HP-MSCs promoted the migration ability of the cells, prevented cell ... See full document
10
Temsirolimus in the treatment of relapsed and/or refractory mantle cell lymphoma
... Responses (30%) to temsirolimus by patients with MCL are higher than those reported by patients with renal cell carcinoma, breast cancer, lung cancer, and glioblastoma (about 10%). Why patients affected by ... See full document
9
Dendrosomal curcumin nanoformulation downregulates pluripotency genes via <em>miR-145</em> activation in U87MG glioblastoma cells
... Abstract: Glioblastoma is an invasive tumor of the central nervous ...U87MG cells, a cellular model of glioblastoma, was evaluated by considering master genes of pluripotency and regulatory miRNA ... See full document
15
Histone methyltransferase SUV39H2 regulates cell growth and chemosensitivity in glioma via regulation of hedgehog signaling
... on cell growth and chemosensitivity to TMZ in ...inhibit glioma cell growth and enhance chemosensitivity by combining SUV39H2 inhibitors with ...cancer stem cells in glioma ... See full document
12
Emerging role of Hpo signaling and YAP in hepatocellular carcinoma
... solid lines or drawn as proteins in direct contact with each ...Dashed lines indicate genetic interactions for which no direct protein-protein interactions have been ...or inhibition, ...Dev. ... See full document
10
Regression/Eradication of gliomas in mice by a systemically- deliverable ATF5 dominant-negative peptide
... tumor cells, and for TUNEL to identify dying ...brain cells (in the contralateral hemisphere from the tumor) showed Flag staining indicative of extensive uptake of Pen-d/n-ATF5- RP; there was no signal with ... See full document
13
Original Article miR-423-5p inhibits the proliferation and metastasis of glioblastoma cells by targeting phospholipase C beta 1
... Apoptotic cells were identified using a terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-based cell detection kit, POD (Roche Applied ...The cells were fixed on slides with 4% ... See full document
10
Drug-screening and genomic analyses of HER2-positive breast cancer cell lines reveal predictors for treatment response
... trastuzumab-nonresponsive cell lines, KPL4 and SUM190PT (both with mutated PIK3CA and loss in PTEN), were significantly more sensitive to the Akt1/2 kinase inhibitor than the rest of the ... See full document
14
Endotoxin-activated microglia injure brain derived endothelial cells via NF-κB, JAK-STAT and JNK stress kinase pathways
... endothelial cells, suggesting one pathway that might explain the toxicity observed in our ischemia ...endothelial cells. LPS also directly induced cell death in microglia, but not endothelial ... See full document
15
Nanocarrier-based drug combination therapy for glioblastoma
... orthotopic glioma with high tumor to background ratio allowing accurate tumor delineation ...single cell level fluorescence imaging ex vivo ...in cell identification and localization in ... See full document
18
Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo
... including glioblastoma (Supplementary Figure S1), which supports the notion that deubiquitinating enzymes represent a valid target in this disease and that their inhibition may add to a concerted strategy ... See full document
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