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[PDF] Top 20 Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma

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Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma

Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma

... of BRAF using rabbit anti-BRAF with Anti-Rabbit PLUS (Sigma-Aldrich, DUO92002) and Anti-Rabbit MINUS was used as a techni- cal positive ...detect ER, the SelectivFX Fluor 488 ER Labeling Kit ... See full document

13

Dangerous liaisons: flirtations between oncogenic BRAF and GRP78 in drug resistant melanomas

Dangerous liaisons: flirtations between oncogenic BRAF and GRP78 in drug resistant melanomas

... therapy-induced ER stress, specifically that associated with PERK activation, also promotes cancer cell sur- vival via activation of autophagy ...in melanoma cells and may also ... See full document

5

Melatonin Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib through the PERK-ATF4-Beclin1 Pathway

Melatonin Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib through the PERK-ATF4-Beclin1 Pathway

... of resistance to the targeted drug sorafenib in the treatment of hepatocellular carcinoma (HCC) are poorly ...sorafenib resistance and to elucidate the role of melatonin in overcoming sorafenib ...sorafenib ... See full document

16

Dabrafenib and trametinib activity in a patient with BRAF V600E mutated and microsatellite instability high (MSI-H) metastatic endometrial cancer

Dabrafenib and trametinib activity in a patient with BRAF V600E mutated and microsatellite instability high (MSI-H) metastatic endometrial cancer

... of BRAF oncogene, thus further pro- longing response to BRAF inhibitor based treatment and suggesting that combination of target treatments can be a better therapeutic strategy for this type of ... See full document

5

Host immunity contributes to the anti melanoma activity of BRAF inhibitors

Host immunity contributes to the anti melanoma activity of BRAF inhibitors

... reduce melanoma tumor growth ...SM1 melanoma variants were CCR2 negative, and yet our data support an important role for melanoma CCL2 production in the natural development and growth of these ... See full document

12

B19, a Novel Monocarbonyl Analogue of Curcumin, Induces Human Ovarian Cancer Cell Apoptosis via Activation of Endoplasmic Reticulum Stress and the Autophagy Signaling Pathway

B19, a Novel Monocarbonyl Analogue of Curcumin, Induces Human Ovarian Cancer Cell Apoptosis via Activation of Endoplasmic Reticulum Stress and the Autophagy Signaling Pathway

... affect ER homeostasis and interfere with proper protein folding, ultimately causing an imbal- ance between ER protein folding load and capacity, leading to the accumulation of unfolded or misfolded proteins ... See full document

12

Mitochondrial ATF2 translocation contributes to apoptosis induction and BRAF inhibitor resistance in melanoma through the interaction of Bim with VDAC1

Mitochondrial ATF2 translocation contributes to apoptosis induction and BRAF inhibitor resistance in melanoma through the interaction of Bim with VDAC1

... mitochondria induced by ATF2. Cytotoxic stress reduced mitochondrial membrane potential, as determined by alterations in JC-1 dye aggregation, whereas ATF2 depletion did not alter either of the fluorescence ... See full document

16

Endoplasmic reticulum stress-induced autophagy determines the susceptibility of melanoma cells to dabrafenib

Endoplasmic reticulum stress-induced autophagy determines the susceptibility of melanoma cells to dabrafenib

... Notes: Western blotting analysis of dabrafenib treatment on er stress of a375 (A) and Mel624 (B) cells. Both cell lines were treated with vehicle or the indicated concentrations of dabrafenib for 24 hours. ... See full document

8

The use of immunotherapy in the treatment of melanoma

The use of immunotherapy in the treatment of melanoma

... advanced melanoma have a compromised anti-tumor immune response leading to tumor immune tolerance and a tumor microenvironment conducive to disease ...successfully overcomes this tumor-mediated immune ... See full document

9

The cytotoxic effects of dimethyl sulfoxide in mouse preimplantation embryos: a mechanistic study

The cytotoxic effects of dimethyl sulfoxide in mouse preimplantation embryos: a mechanistic study

... apoptosis, ER stress, and developmental arrest in 2-cell ...The ER was immunostained using anti-PDI antibody and fluorescence intensity was determined using confocal microscopy at the 2-cell stages ... See full document

18

BRAF Mutant Gastrointestinal Stromal Tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance

BRAF Mutant Gastrointestinal Stromal Tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance

... of BRAF have been described in patients with gastrointestinal stromal tumor (GIST), but treatment of GIST with BRAF inhibitors and mechanisms of mediating the emergence of resistance in GIST have not ... See full document

6

ATG7 regulates energy metabolism, differentiation and survival of Philadelphia chromosome-positive cells

ATG7 regulates energy metabolism, differentiation and survival of Philadelphia chromosome-positive cells

... mediated autophagy inhibition, CML cells switch from glycoly- sis to mitochondrial respiration, indicating that autophagy plays a role in maintaining the Warburg effect ...of autophagy rather than by ... See full document

14

Targeting Notch enhances the efficacy of ERK inhibitors in BRAF- V600E melanoma

Targeting Notch enhances the efficacy of ERK inhibitors in BRAF- V600E melanoma

... in resistance to BRAF inhibitors [11-13, 15], we first examined the mutation status and expression of this tumor suppressor (Figure 1D, Table ...confer resistance to ERK ...of melanoma driven ... See full document

12

WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors

WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors

... in melanoma patient ...triplicate melanoma biopsies before treatment and upon disease progression to study biomarkers of response and resistance to these ...with BRAF-mutant metastatic mela- ... See full document

15

BRAFV600E -dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells

BRAFV600E -dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells

... pharmacological targeting of an oncogenic driver is strongly influenced by cancer- or cell type- specific ...mutant BRAF in mTORi response has not been ... See full document

12

Effect of sodium 4 phenylbutyrate on clenbuterol mediated muscle growth

Effect of sodium 4 phenylbutyrate on clenbuterol mediated muscle growth

... (ER) stress, caused by over- reaching the protein synthetic capacity of the ...the ER in the maintenance of skeletal muscle mass is unknown, ER-stress (induced by treatment with ... See full document

16

Reactive Oxygen Species Related Noncoding RNAs as Regulators of Cardiovascular Diseases

Reactive Oxygen Species Related Noncoding RNAs as Regulators of Cardiovascular Diseases

... cell apoptosis and ROS production in the rat model [93]. The tumor suppressor gene p27 was frequently upregulated in the ischemic heart associated with enhanced ROS production, and triggered cell apoptosis by activating ... See full document

8

Co clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma

Co clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma

... of BRAF inhibitor resistance patterns in human melanoma ...These resistance classifications are not dependent on knowledge of the underlying resistance-conferring DNA ... See full document

13

Mitochondrial oxidative stress is the achille’s heel of melanoma cells resistant to Braf-mutant inhibitor

Mitochondrial oxidative stress is the achille’s heel of melanoma cells resistant to Braf-mutant inhibitor

... It is widely admitted that most cancer cells exhibit specific metabolic phenotypes that allow them to highly proliferate and survive to adverse environmental conditions [11]. Lessons from the last decade indicate that ... See full document

13

Enhanced Autophagy in the Kidney of AQP11 Null Mice Developing Polycystic Kidneys

Enhanced Autophagy in the Kidney of AQP11 Null Mice Developing Polycystic Kidneys

... defective ER function since abnormal glycosylation of polycystin-1 (PC-1) have caused its defective transfer to the plasma membrane ...that ER stress induced by the absence of AQP11 may ... See full document

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