[PDF] Top 20 Tau exon 10 alternative splicing and tauopathies
Has 10000 "Tau exon 10 alternative splicing and tauopathies" found on our website. Below are the top 20 most common "Tau exon 10 alternative splicing and tauopathies".
Tau exon 10 alternative splicing and tauopathies
... 3R-tau: tau with three-microtubule-binding repeats; 4R- tau: tau with four-microtubule-binding repeats; ACE: A/C- rich enhancer; AD: Alzheimer disease; AGD: argyrophilic grain dementia; CBD: ... See full document
10
CRISPR/Cas9 mediated genome editing induces exon skipping by alternative splicing or exon deletion
... apparent exon skipping by ...targeting exon 6 of p65 / RelA , we isolated a biallelic p65 clone (#15): one allele harbors a 1-nt “+A” insertion and the other harbors a 2268-bp deletion that removes exons 5, ... See full document
8
Differential alternative splicing regulation among hepatocellular carcinoma with different risk factors
... of exon-exon junction reads. All possible AS events, that is, exon skipping (ES), intron retention (IR), alternative 3′ splicing site (A3SS), alternative 5′ splicing site ... See full document
12
The Role of Tau Protein in Diseases
... neuronal tau inclusions. Tau is also present in hyperphosphorylated form, but only certain molecular weight forms can be detected by ...cytoplasmic tau inclusions in neurons of the frontal lobe, ... See full document
16
The Alternative Splicing Mutation Database: a hub for investigations of alternative splicing using mutational evidence
... human Exon-Intron Database, most from version 35p1, some from version 36p1 ...mutant exon sequences for each mutation are stored in the sequences ... See full document
7
PCBP1 inhibits the expression of oncogenic STAT3 isoform by targeting alternative splicing of STAT3 exon 23
... Figure 3. Downregulating the ratio of STAT3 α/β inhibits the cell growth of OSCC cell through overexpression of PCBP1. (A) CAL 27 or SCC-9 cells with T7-PCBP1 stable overexpression were seeded into 12 well plates on Day ... See full document
10
Molecular Mechanisms of Alternative Splicing Regulation: An Investigation of the Spliceosome Repressed by Hnrnp L on Cd45 Exon 4
... ESS1-mediated splicing repression in ...of exon 4 by an anti- sense oligo disrupts ESS1-medaited splicing ...of exon 4 go does not overcome the ESS1-mediated splicing repression on the ... See full document
133
A phylogenetic generalized hidden Markov model for predicting alternatively spliced exons
... 10. The FANTOM Consortium, Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest ARR, Zavolan M, ... See full document
13
Slowly progressive dementia caused by MAPT R406W mutations: longitudinal report on a new kindred and systematic review
... protein tau [1]. Tau is composed of three- or four-microtubule binding domains, depending on alternative splicing of exon 10, leading to the three- repeat (exon ... See full document
16
Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine
... 3′ splicing and the dis- tal C-terminal tails of mu opioid receptors in mediating complex morphine actions (see summary in Table ...of exon 7–associ- ated variants in morphine-induced receptor ... See full document
14
Changes in alternative splicing of human and mouse genes are accompanied by faster evolution of constitutive exons
... employ alternative splicing to different extents, this could explain why alternatively spliced genes are conserved compared to the genome as a ...undergo alternative splicing through ... See full document
11
Can the HIV-1 splicing machinery be targeted for drug discovery?
... four alternative 5 ′ splice sites (ss; SD1–4) and eight alternative 3 ′ splice acceptor sites (SA1, SA2, SA3, SA4a, SA4b, SA4c, SA5, and SA7; Figures 1 and ...including exon splicing enhancing ... See full document
13
Calpain-Mediated Tau Cleavage: A Mechanism Leading to Neurodegeneration Shared by Multiple Tauopathies
... 17-kDa tau fragment, we used a full-length tau con- struct with an N-terminal 6-Histidine tag inserted into the pT7C plasmid (hT40- pT7C plasmid) as a ...17-kDa tau construct was generated by ... See full document
10
Molecular Characterization and Alternative Splicing of a Sodium Channel and DSC1 Ortholog Genes in Liposcelis bostrychophila Badonnel (Psocoptera: Liposcelididae)
... 8A). Exon 23 located in the linker between domains II and III, was an internally optional spliced exon that were generated using an alternative 3′ splicing site in an adjacent downstream ... See full document
15
Unproductive alternative splicing and nonsense mRNAs: A widespread phenomenon among plant circadian clock genes
... extensive alternative splicing yielding nonsense mRNAs of clock genes is demonstrated beyond ...of alternative splicing in clock genes to the overall background in Arabidopsis? Is it the case ... See full document
15
Disruption of the splicing enhancer sequence within exon 27 of the dystrophin gene by a nonsense mutation induces partial skipping of the exon and is responsible for Becker muscular dystrophy
... around exon 27 was exam- ined next, since exon skipping is usually induced by a mutation affecting the splicing consensus ...of exon 27 was not available, this region was cloned from control ... See full document
8
Serotonin 2C Receptor Alternative Splicing in a Rat Model of Orofacial Neuropathic Pain
... and exon Vb-skipped 5HTR2C were evaluated, according to the manufacturer’s protocol, by quantitative real-time RT-PCR with an ABI PRISM 7900HT (Applied Biosystems, Foster City, CA) and Taq- Man probes designed and ... See full document
6
Transposable Element Insertions Respecify Alternative Exon Splicing in Three Drosophila Myosin Heavy Chain Mutants
... deoxynucleotidyl terminal transferase (Promega, Madison, mRNAs. Subsequent work has demonstrated that each WI). Hybridization signals were visualized either by standard mutant results from a transposable element ... See full document
10
Spatial patterns of the tau-immunoreactive inclusions in eight different tauopathies are consistent with the spread of pathogenic tau
... All procedures performed in these studies were in accordance with the ethical standards of the Institute of Psychiatry, London, UK; Human Studies Committee of Washington University School of Medicine, St Louis, Missouri, ... See full document
9
Multiple effects of curcumin on promoting expression of the exon 7-containing SMN2 transcript
... Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder with an estimated incidence of 1 in 6000 live births, representing the primary genetic cause of infant mortality (Monani 2005; Burghes and ... See full document
9
Related subjects