[PDF] Top 20 Temporal regulation of HIF-1 and NF-κB in hypoxic hepatocarcinoma cells
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Temporal regulation of HIF-1 and NF-κB in hypoxic hepatocarcinoma cells
... cultured cells using TRIzol, and cDNA was synthesized with M-MLV reverse transcriptase according to the manufacturer’s ...for 1 min, PCR was performed for 30 cycles (30 s at 94°C, 1 min at 53°C and 2 ... See full document
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ERβ regulation of NF- B activation in prostate cancer is mediated by HIF-1
... T cells by down regulating the expression of NF-κB ...and NF-κB is evident [7], the mechanism by which ERβ regulates the NF-κB pathway has not been ...canonical ... See full document
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Interferon α sensitizes HBx expressing hepatocarcinoma cells to chemotherapeutic drugs through inhibition of HBx mediated NF κB activation
... c-Rel, NF-κB1/p50, and NF-κB2/p52. In resting cells, NF-κB dimers are sequestered in the cy- toplasm as latent complexes through binding to the members of a family of ankyrin repeat ... See full document
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Cycling hypoxia induces chemoresistance through the activation of reactive oxygen species mediated B cell lymphoma extra long pathway in glioblastoma multiforme
... tiple hypoxic areas that exhibit elevated HIF-1 signal transduction activity, resulting in the deregulated expres- sion of downstream target genes that contribute to GBM malignancy ...with ... See full document
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Hypoxia Regulation of NFκB signalling during inflammation: the role of hydroxylases
... individual NF κ B members have differential effects on HIF-1 α mRNA levels [44], illustrating another level of complexity in this ...Several NF κ B subunits (RelA, RelB, c-Rel, p50, p52) were ... See full document
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Hypoxia attenuates the proinflammatory response in colon cancer cells by regulating IκB
... a HIF- independent ...under hypoxic than normoxic conditions, resulting in decreased IKK phosphorylation, slightly increased IκBα protein levels and clearly increased IκBα positive cell numbers after 30 ... See full document
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... active NF-κB binding site has been localized upstream of the hypoxia-inducible factor-1 alpha (HIF1A) promoter (at residues-197/188) [7], and the activation of NF-κB increases HIF1A ... See full document
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Hypoxic regulation of osteoclast differentiation and bone resorption activity
... transporter 1; ATP, adenosine triphosphate; PGK1, phosphoglycerate kinase 1; PFKFB4, 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 4; ALDOC, aldolase C; LDHA, lactate dehydrogenase A; PDH, pyruvate ... See full document
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Toll-like receptor 2-mediated NF-kappa B pathway activation in ocular surface epithelial cells
... Real time PCR was performed as described previously ac- cording to the manufacturer’s instructions [24]. In sum- mary, total RNA was extracted from HCE-T cells using the RNeasy Mini Kit (Qiagen, Hilden Germany) ... See full document
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Androgen receptor activity modulates responses to cisplatin treatment in bladder cancer
... of NF-κB in bladder cancer ...of NF-κB protein (Figure 4A) and mRNA (Figure 4B), respectively, compared with AR- negative control ...AR-positive cells, R1881 increased the expression of ... See full document
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Up-regulation of hypoxia inducible factor-1α by cobalt chloride correlates with proliferation and apoptosis in PC-2 cells
... Human HIF-1 has been depurated and isolated, it is a heterodimeric transcription factor composed of oxygen-dependent HIF-1a and constitutively expressed HIF-1b subunits, HIF-1 ... See full document
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NF- B signaling mediates acquired resistance after PARP inhibition
... by NF- κB signaling (4 genes out of 7 DEG in R10 vs parental and 4 genes out of 8 DEGs in R100 vs parental, highlighted in bold letter in Table ...type 1-” and “TNF family-” in parental vs R10 and ... See full document
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The oncogenic Golgi phosphoprotein 3 like overexpression is associated with cisplatin resistance in ovarian carcinoma and activating the NF-κB signaling pathway
... canccer cells was determined using the MTT assay as previously described (Landen CN, et ...3 cells were seeded onto 96-well plates and incubated at 37 °C ...overnight. Cells were then transfected ... See full document
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Original Article Inhibition of RIPK1 expression and facilitation of TRAIL-induced hepatocellular carcinoma cell apoptosis by miR-141
... improvements, 1-year and 2-year sur- vival rates were only ...tumor cells, transforming cells and viral infecting cells for inducing apoptosis, whilst had no significant toxicity or killing ... See full document
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Computational modelling of NF-κB activation by IL-1RI and its co-receptor TILRR, predicts a role for Cytoskeletal Sequestration of IκBα in inflammatory signalling.
... factor NF- κ B (nuclear factor kappa B) is activated by Toll-like receptors and controlled by mechanotransduction and changes in the ...in regulation of NF- κ ...the NF- κ B pathway, which ... See full document
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Original Article Hypoxia induced HIF-1α expression promotes angiogenesis, tumor budding cell survival and cell proliferation arrest in high-grade tumor budding colorectal carcinomas
... of HIF-1α is to stimulate the proliferation and migration of endothelial cells and angiogenesis, by incre- ased expression of vascular endothelial growth factor ...budding cells are present, can not ... See full document
9
An Intensive Mind and Body Therapeutic Program Leads to Alteration in Gene Expression Critical to Aging Process in Peripheral Blood Stem Cells
... stem cells (HSC) and peripheral blood mono- nuclear cells ...stem cells using affymetrix DNA micro- array ...pathway, hypoxic HIF-1-alpha, key regulator of programmed cell death, ... See full document
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NF κB: pivotal mediator or innocent bystander in atherogenesis?
... vascular cells may reduce vascular cell oxidative ...inhibit NF- κ B activation in macrophages and cultured endothelial cells (34) and decrease oxida- tive stress in the porcine coronary artery ... See full document
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Original Article Effects of NF-κB and hypoxia on the biological behavior of Y79 retinoblastoma cells
... cancer cells among members of the MMP ...that HIF-1α and NF-κB activa- tion was significantly correlated with VEGF pro- tein expression, and NF-κB could also promote expression ... See full document
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Therapeutic potential of inhibition of the NF κB pathway in the treatment of inflammation and cancer
... the NF-κB pathway Flavonoids are naturally occurring phenolic com- pounds, found in plants, that exhibit a variety of biolog- ical activities, including suppression of inflammation, cancer chemoprevention, ... See full document
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