[PDF] Top 20 The 6R’s of drug induced nephrotoxicity

... Often, the sub-phenotype is difficult to distinguish from laboratory parameters (i.e. ATN vs. AIN) and kidney bi- opsy information can guide treatment decisions. Several studies have demonstrated the importance of kidney ... See full document

... WHO: World Health Organisation; BUN: Blood urea nitrogen; GFR: Glomerular filtration rate; N N-AIDS: Non-steroidal anti-inflammatory drugs; EGCG: Epigal- locatechin gallate; TNF- α: Ttumour necrosis factor- α; MDA: ... See full document

... Ash values including total ash, acid insoluble ash and water soluble ash of fruit powder were done as per Indian Pharmacopoeia. The results are shown in Table 1.Successive extractive value with different solvents with ... See full document

... purchased drug was established as fruit of Physalis alkekengi by the scientist working at NISCAIR (National Institute of Science Communication and Information Resources), ... See full document

... chemotherapeutic drug used for treating broad spectrum of malignancies such as testis, ovary, bladder, head and neck, esophagus, breast, stomach and prostate, small and non-small cell lung cancer , Hodgkin , ... See full document

... of drug combination therapy is the potential interactions, either direct or indirect, that the drugs may have on each other or the metabolic changes that each drug may induce that may potentially impact the ... See full document

... www.wjpr.net Vol 3, Issue 4, 2014. 1027 ability to function, or chronic renal failure, in which there is slow deterioration of kidney function. If untreated, renal failure can cause death. Chronic exposure to drugs, ... See full document

... of drug-induced disorders has demonstrated that medication overuse could lead to nephrotoxicity and po- tential renal damage ...Particularly, drug-associated nephrotoxicity accounts for ... See full document

... Chemicals: Dichlorvos (2, 2-dichlorovinyl dimethyl phosphate – DDVP) was bought from a local chemist in Ibadan, Nigeria. Thiobarbituric acids (TBA) were bought from Aldrich Chemical Co. (Milwaukee, WI, USA). Glutathione, ... See full document

... AG-induced nephrotoxicity include extended-interval dosing, and drug trough level monitoring with dose adjustment, but these are only partially ... See full document

... We conducted a single-centre retrospective cohort study of all HIV-infected adults who were started on tenofovir-based antiretroviral regimens at a local tertiary hospital from 1 January 2008 to 31 December 2010. The ... See full document

... End stage renal disease is a most common & serious complications of diabetic nephropathy. A significant dose dependent inhibition (P < 0.001) was found in lipid peroxidation induced by ferric ... See full document

... eral in vitro studies have shown that eleva- tion of MT levels in certain cultured cells can result in resistance to cisplatin. 25, 26 It has been reported that the active metabo- lites of cisplatin can react quickly ... See full document

... cisplatin nephrotoxicity, is showed clinically as lower glomerular filtration rate, decreased serum magnesium and potassium levels 1–3 ...cisplatin nephrotoxicity 4, 5 ... See full document

... Aim of the present study to evaluate the Nephro-protective activity of Nelumbo nucifera root, flowers & leaves extract by gentamicin induced nephrotoxicity in experimental animals. However there are no ... See full document

... antitumoral induced lipid peroxidation and damage in the renal tissues of ...cisplatin nephrotoxicity occurs as a result of oxidative stress and increased generation of superoxide anion, hydrogen peroxide, ... See full document

... and the liver. Chronic ethanol administration decreases the renal tubular reabsorption and reduces renal function. Functional abnormalities of renal tubules may be associated with ethanol- induced changes in ... See full document

... synthetic drug which relieves overall insufficiency of ...the Nephrotoxicity can be checked using anti-oxidants like Eugenol that is a main component of Ocimum ... See full document

... The result of present study shows that gentamicin induces nephrotoxicity. This ultimately affects kidneys and its important functions. In contrast MEPN has reduced the damages occurred to the kidneys caused by ... See full document

... (1) (a) A. Varki, Essentials of Glycobiology; Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1999 (b) P. Pale and G. M. Whitesides, J. Org. Chem., 1991, 56, 4547–4549 (c) S. Fujita, N. Oka, F. Matsumura, ... See full document