[PDF] Top 20 The Dissection of Expression Quantitative Trait Locus Hotspots
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The Dissection of Expression Quantitative Trait Locus Hotspots
... gene expression frequently identify loci with broad effects on gene expression: expression quantitative trait locus ...the locus on the expression traits that map ... See full document
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Expression Quantitative Trait Locus Mapping of Toxoplasma Genes Reveals Multiple Mechanisms for Strain-Specific Differences in Gene Expression
... There are 128 different possible combinations of the seven SNPs in the 5 ⬘ half of the 46.m01601 promoter. Testing all possible combinations would be prohibitive in terms of the effort involved, so we focused on four ... See full document
12
Quantile-Based Permutation Thresholds for Quantitative Trait Loci Hotspots
... the trait data, preserving the correlation structure among phe- ...spurious hotspots by chance under the null hypothesis of no ...one trait, and a conservative permutation threshold for the maximum ... See full document
19
Whole genome sequence analyses of brain imaging measures in the Framingham Study
... = expression quantitative trait locus; FHS = Framingham Heart Study; FLAIR = fluid- attenuated inversion recovery; GWAS = genome-wide association studies; HPV = hippocampal volume; LD = linkage ... See full document
11
Dissection of a Synthesized Quantitative Trait to Characterize Transgene Interactions
... Six transgenic tobacco lines, each homozygous for the P-glucuronidase (GUS) gene at a different locus, and wild type were selfed and intercrossed to evaluate GUS activity [r] ... See full document
6
Genetic Predisposition to Multiple Myeloma at 5q15 Is Mediated by an ELL2 Enhancer Polymorphism.
... an expression quantitative trait locus (eQTL) analysis using mRNA expression data on CD138-purified plasma cells from 841 MM case subjects from the UK MRC MyIX trial and German- ... See full document
10
Ensemble genomic analysis in human lung tissue identifies novel genes for chronic obstructive pulmonary disease
... size. Expression quantitative trait locus (eQTL) analysis tests the association between genetic variants and gene expression and can point to relevant single nucleotide polymorphisms ... See full document
12
Molecular Dissection of a Major Gene Effect on a Quantitative Trait: The Level of Alcohol Dehydrogenase Expression in Drosophila melanogaster
... A molecular mapping experiment shows that a major gene effect on a quantitative trait, the level of alcohol dehydrogenase expression in Drosophila melunogaster, is due to [r] ... See full document
6
Multilevel-analysis identify a cis -expression quantitative trait locus associated with risk of renal cell carcinoma
... v2 Expression BeadChip kits (Illumina) was used to profile the whole genome-wide gene expression and were read using a BeadStation 500 scanner ...altered expression level, average p-value, and median ... See full document
13
Characterizing the Saltol quantitative trait locus for salinity tolerance in rice
... Saltol locus between different RILs in the original mapping ...marker locus, ...for expression of candidate genes underlying Saltol, revealing that the SKC1 gene transcripts increased in Pokkali and ... See full document
13
hairy: A Quantitative Trait Locus for Drosophila Sensory Bristle Number
... for only 7% of the total genome. It is illustrative to deviation. Evaluating this expression with ␣ ⫽ 0.05 and calculate the potential contribution of del2187in to nat-  ⫽ 0.1 gives n ⱖ 1344 for ␦ ⫽ 0.25 and n ⱖ ... See full document
10
An association analysis to identify genetic variants linked to asthma and rhino-conjunctivitis in a cohort of Sicilian children
... and expression quantitative trait locus (eQTL [12]) such as summary-data based Mendelian randomization (SMR; [13]), PrediXcan [14], MetaXcan [15], would be useful in discovering new genetic ... See full document
6
Genomic interrogation of familial short stature contributes to the discovery of the pathophysiological mechanisms and pharmaceutical drug repositioning
... eQTL: Expression quantitative trait locus; FDR: False discovery rate; FR: Fruchterman-Reingold; FSS: Familial short stature; GAD: Gene-Disease Associations; GO: Gene ontology; GSEA: Gene set ... See full document
12
Quantitative Trait Locus Analysis of Leaf Dissection in Tomato Using Lycopersicon pennellii Segmental Introgression Lines
... Figure 2.—Leaf pheno- types representative of the parental lines and the four types of QTL. The sixth postembryonic mature leaf representing the parental types L. esculentum cv. M82 (A) and L. pennellii (F) as well as ... See full document
10
Expression quantitative trait locus analysis for translational medicine
... Unfortunately, there is as yet no database for such eSNPs, perhaps because there is only good functional evidence for a small number of individual sites. In the meantime, there are several resources that can help in- ... See full document
14
Impact of gene expression data pre processing on expression quantitative trait locus mapping
... Different DNA chip pre-processing methods have been shown to influence measures of gene expression [6,8,9]. Therefore, the choice of a pre-processing method signifi- cantly affects linkage results obtained in ... See full document
5
Transcriptional Regulatory Pattern in Yeast Revealed through Expression Quantitative Trait Locus Mapping
... linking expression traits and physical markers to their corresponding genes, our implemen- tation will help scientists conceptualize each eQTL as a list of pairwise relationships between a trait gene and ... See full document
133
Quantitative Trait Locus Study Design From an Information Perspective
... We examine the efficiency of different genotyping and phenotyping strategies in inbred line crosses from an information perspective. This provides a mathematical framework for the statistical aspects of QTL experimental ... See full document
18
Disease-specific regulation of gene expression in a comparative analysis of juvenile idiopathic arthritis and inflammatory bowel disease
... gene expression [44, ...gene expression studies, for the most part independent of ...gene expression in the ...gene expression samples from over 500 studies [45], and these relationships were ... See full document
16
Identification of recombination hotspots and quantitative trait loci for recombination rate in layer chickens
... The number of recombination events was treated as a quantitative trait to map genetic variants that influence recombination rates. The proportion of genetic variance explained by each 1-Mb region across the ... See full document
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