[PDF] Top 20 The flexibility and dynamics of protein disulphide isomerase
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The flexibility and dynamics of protein disulphide isomerase
... the flexibility analysis clearly finds energetically plausible interdomain orienta- tions, which do not simply regress from the “closed” structure toward the orientations found in the crystal ...the ... See full document
11
Modeling of Protein Structural Flexibility and Large-Scale Dynamics: Coarse-grained Simulations and Elastic Network Models
... Structural flexibility can range from small side-chain fluctuations to large rearrangements of the entire protein backbone or its fragments, for example disordered regions ...about protein structures ... See full document
21
Environmental Dynamics, Financial Flexibility and Enterprise Strategic Change
... tal dynamics on the strategic change of manufacturing enterprises, and ex- plores how corporate financial flexibility adjusts the relationship between envi- ronmental dynamics and strategic ... See full document
15
An investigation into the micro dynamics of routine flexibility
... Besides being flexible ostensively, routines may also be flexible in the performative aspect because they are inherently improvisational (Feldman and Pentland 2003). The performances of routines are somewhat novel ... See full document
256
The temporal dynamics of Arc expression regulate cognitive flexibility
... cognitive flexibility required to efficiently complete the ...of protein trans- lation, synthesis, and turnover is required for the correct expres- sion of mGluR-LTD and learning behavior (Citri et ... See full document
18
‘Something in the way she moves’ : the functional significance of flexibility in the multiple roles of protein disulfide isomerase (PDI)
... PDI flexibility with those of a recent molecular dynamics simulation based on the same hPDI structures (Yang et al, ...of flexibility simulations and, as in these MD simulations, find that the a and ... See full document
35
Attitude Control using a Disturbance Observer Based Controller
... The launch vehicles are broadly divided into two main types: Re-Usable Launch Vehicle and Extinguishable Launch vehicle. The general equations describing motion are initially obtained by ordinary differential equations ... See full document
11
Water in Protein Cavities: Free Energy, Entropy, Enthalpy, and its Influences on Protein Structure and Flexibility
... water [21]. Before any MD simulations, each solvated system was subjected to a 100 cycles of steepest-descent energy minimization followed by a 100 cycles of conjugate gra- dient minimization. The solvated and minimized ... See full document
124
Expression of protein disulfide isomerase A3 precursor in colorectal cancer
... ReadyPrep protein extraction kit (Bio-Rad, Hercules, CA, USA) for 20 ...The protein concentrations were determined using a bicinchoninic acid protein assay kit (Abcam, Rockford, IL, ... See full document
8
Lemon protein disulfide isomerase: cDNA cloning and biochemical characterization
... disulfide isomerase (PDI), a member of thioredoxin- superfamily, plays a key role in catalyzing disulfide bond for- mation, reduction, and ...reported protein folding enzyme (Venetianer and Straub 1963a, ... See full document
7
Regularities and Dynamics of Vegetation Distribution in the Ecosystem of the Atyrau region
... and dynamics of spreading vegetation ecosystems in the Atyrau region, which will make it possible to optimize the species composition in the regions through the use of plants that meet the zonal criteria in the ... See full document
7
Characterization of two protein disulphide iosmerases from the endocytic pathway of Trypanosoma brucei
... putative protein disulfide isomerases (PDIs) that respectively contained one and two double-cysteine redox-active sites and corre- sponded to a single domain PDI and a class 1 ...possess isomerase activity, ... See full document
9
Analysis of conformational flexibility of loop 110-120 of protein tyrosine phosphatase 1B
... the standard one (difference up to 11.4 Å in the middle of the loop). This might be explained by the influences of bulky inhibitors, though they do interact only with the end of the loop 110-120 (residues 118-120). It is ... See full document
8
Flexibility and Complexity of Effective Enterprises
... The aim o f this research was to give contribution to the efforts that are being made to develop the procedures o f structural designing o f industrial systems - highly effective enterprises. For that purpose, this paper ... See full document
15
Structural studies on protein disulphide isomerase
... A cyan background denotes residues identified as part of the hydrophobic binding site in the yeast structure 13 and the corresponding residues in the human protein.. Two further residues[r] ... See full document
325
S nitrosylation of the thioredoxin like domains of protein disulphide isomerase and its role in neurodegenerative conditions
... of protein aggregates strongly features in PD pathol- ...where protein aggregation and increased cellular stress, among others, contribute to disease pathology (reviewed in Nakamura and Lipton, ... See full document
8
Evolutionary Relationship of Wheat Protein Disulphide Isomerase (PDI) Gene Promoter Sequence Based on Phylogenetic Analysis
... Protein disulphide isomerase (PDI) is an oxidoreductase enzyme abundant in the endoplasmic reticulum (ER). In plants, PDIs have been shown to assist the folding and deposition of seed storage ... See full document
8
Alternative conformations of the x region of human protein disulphide isomerase modulate exposure of the substrate binding b’ domain
... The domain boundaries of human PDI were defined in previous work 11-12 ; the constructs studied here correspond to the complete b’ domain (P218-G332) and subsequent x region (K333-P351) with a short N- terminal tag ... See full document
32
Dynamic Thiol/Disulphide Homeostasis in Patients with Vaginitis
... Of the women with vaginitis included in study, 19 had candida vaginitis, 15 had bacterial vaginosis and 11 had trichomonas vaginitis. The diagnosis of vaginitis was confirmed by laboratory tests after suggestion by the ... See full document
5
Use of folding modulators to improve heterologous protein production in Escherichia coli
... shock protein 70 (Hsp70) family of proteins are ubiquitous, highly conserved molecules whose predomi- nant unifying feature is the ability to bind short, linear hydrophobic regions of polypeptides ... See full document
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