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[PDF] Top 20 The structure and function of the CGRP receptor

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The structure and function of the CGRP receptor

The structure and function of the CGRP receptor

... Two further mutations (H219A and C212A) also reduced cAMP signalling by approximately 10-fold. The C212 residue is thought to reside at the top of TM3 and has been shown to interact with C282 of ECL2. Whilst this was ... See full document

296

The structure and function of vertebrate fibroblast growth factor receptor 1

The structure and function of vertebrate fibroblast growth factor receptor 1

... FGFR1 function during ...FGF receptor expressed at the MHB (Wilke et ...the receptor for FGF8-mediated signal transduction at the MHB in these ... See full document

8

Structure and function of the GabaA receptor

Structure and function of the GabaA receptor

... nACh receptor family (Figure ...nACh receptor from muscle in which the L9' residue in the y subunit was changed to serine (L9'S) report changes in channel open time but no change in conductance (Filatov and ... See full document

178

Structure and function of basement membranes

Structure and function of basement membranes

... Int J Dev BioI 39 781 787 (1995) 781 Structure and function of basement membranes EVA ENGVALL * Department of Developmental BiologV, The Wenner Gren Institute, Stockholm University, Stockholm, Sweden[.] ... See full document

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The evolution of the structure of tubulin and its potential consequences for the role and function of microtubules in cells and embryos

The evolution of the structure of tubulin and its potential consequences for the role and function of microtubules in cells and embryos

... By examining sequence alignments between α - and β - tubulin, Kuchnir-Fygenson et al. (2004) identified residues that differ significantly in variability. Most of these residues were shown to be clustered around the ... See full document

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Inventive activity of the Departments of Chemistry and Biochemistry of Enzymes, and Protein Structure and Function of the Palladin Institute of Biochemistry of NAS of Ukraine. Part III. Diagnostic test-systems for analysis of fibrinolysis blood system and

Inventive activity of the Departments of Chemistry and Biochemistry of Enzymes, and Protein Structure and Function of the Palladin Institute of Biochemistry of NAS of Ukraine. Part III. Diagnostic test-systems for analysis of fibrinolysis blood system and novel approaches to thrombosis treatment

... Основним напрямом роботи відділу під її керівництвом стало дослідження механізмів функціонування та регуляції плазміноген/ плазмінової системи як складової гемостазу; визна[r] ... See full document

9

Structure and function of the T cell antigen receptor

Structure and function of the T cell antigen receptor

... This has been further supported by more recent experiments in which a heterologous receptor that activates the inositol phospholipid pathway, the human muscarinic receptor subtype 1, whe[r] ... See full document

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Inventive activity of the Departments of Protein Structure and Function, and Molecular Immunology of the Palladin Institute of Biochemistry of NAS of Ukraine. Part II. National breakthrough in the study and diagnostics of human hemostasis system

Inventive activity of the Departments of Protein Structure and Function, and Molecular Immunology of the Palladin Institute of Biochemistry of NAS of Ukraine. Part II. National breakthrough in the study and diagnostics of human hemostasis system

... Розроблені кількісні методи визначення фібриногену, D-димеру та розчинного фібрину в плазмі крові людини на основі бісайтового т-ІЕА було багаторазово апробовано в клін[r] ... See full document

13

Structure and Function of a Ganglioside Receptor for Porcine Rotavirus

Structure and Function of a Ganglioside Receptor for Porcine Rotavirus

... surface receptor(s) mediates virus recognition ...a function of piglet age and severity of natural rotavirus disease, as well as through the use of various glyco- sylation-deficient mutant or ... See full document

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Inventive activity of the Department of Protein Structure and Function of the Palladin Institute of Biochemistry of NAS of Ukraine. Part I. Development of the diagnostic methods for detection of hemostasis disorders and characterization of certain blood c

Inventive activity of the Department of Protein Structure and Function of the Palladin Institute of Biochemistry of NAS of Ukraine. Part I. Development of the diagnostic methods for detection of hemostasis disorders and characterization of certain blood coagulation factors

... Спосіб тестування загального рівня протромбіну та виявлення його функціонально неактивних форм у плазмі крові / Платонова Т.М., Сушко О.О., Петров О.В., Соловйов Д.О.; [r] ... See full document

12

The impact of obesity on cardiovascular structure and function: the fetal programming era

The impact of obesity on cardiovascular structure and function: the fetal programming era

... Obesity, insulin resistance, diabetes, and cardiovascular risk in children: an American Heart Association scientific statement from the Atherosclerosis, Hypertension, and Obesity i[r] ... See full document

8

Discovery of the congenital nephrotic syndrome gene discloses the structure of the mysterious molecular sieve of the kidney

Discovery of the congenital nephrotic syndrome gene discloses the structure of the mysterious molecular sieve of the kidney

... molecular structure of the size- selective glomerular filtration ...the structure of the slit diaphragm, our recent results represent a noteworthy advance that may help to unravel the nature of this ... See full document

7

C-fibers may modulate adjacent Aδ-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system

C-fibers may modulate adjacent Aδ-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system

... towards CGRP and CLR/RAMP1 bind to two different populations of neurons in the TG and are found in the C- and the myelinated A δ -fibers, respectively, within the dura mater and in trigeminal ganglion ... See full document

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The role and structure of the multidisciplinary team in the management of advanced Parkinson’s disease with a focus on the use of levodopa–carbidopa intestinal gel

The role and structure of the multidisciplinary team in the management of advanced Parkinson’s disease with a focus on the use of levodopa–carbidopa intestinal gel

... All teams meet together regularly to discuss those people with PD who might have an indication for advanced therapy in their area and to exchange experience and knowledge. These meetings involve 10–15 MDSs and 10–15 ... See full document

15

The Strength of the Bus Structure with the Determination of Critical Points

The Strength of the Bus Structure with the Determination of Critical Points

... this function, the monocock is an essential part of the bus as it has to be designed in a way which enables an uninterrupted and simple fitting of all the systems and aggregates to their pre-determined ... See full document

7

The Role of Information and Information Technology in the Management Control Function

The Role of Information and Information Technology in the Management Control Function

... The internal control system is designed to reduce the risk of errors in the enterprise and facts malpractice employees of the firm. Effective control will be enhanced with the appropriate competencies and powers of the ... See full document

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Differential inhibitory response to telcagepant on αCGRP induced vasorelaxation and intracellular Ca2+ levels in the perfused and non-perfused isolated rat middle cerebral artery

Differential inhibitory response to telcagepant on αCGRP induced vasorelaxation and intracellular Ca2+ levels in the perfused and non-perfused isolated rat middle cerebral artery

... of CGRP and its role in cerebrovascular regulation and there are on- going trials with other small molecules of the “gepant” group, possibly lacking liver ...and CGRP may, however, aid the translocation of ... See full document

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Original Article Emodin inhibits the expression of receptor and calcitonin-gene-related peptide release in trigeminal ganglia of trigeminal neuralgia rats

Original Article Emodin inhibits the expression of receptor and calcitonin-gene-related peptide release in trigeminal ganglia of trigeminal neuralgia rats

... 3 receptor and CGRP of TG in TN ...that CGRP up-regulated the active forms of the MAP kinases (p38 and ERK) and PKA in TG, causing a sustained increase in the expression of P2X 3 receptor in ... See full document

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Migraine induction with calcitonin gene-related peptide in patients from erenumab trials

Migraine induction with calcitonin gene-related peptide in patients from erenumab trials

... by CGRP and mi- graine prevention by anti-CGRP mAbs are ...its receptor and activates multiple intracellular signaling pathways of which the most well-known is acti- vation of adenylate cyclase and ... See full document

9

Analysis of the Possibility of the Crown Ether Structure Modification by the Introduction of Chelate Fragment

Analysis of the Possibility of the Crown Ether Structure Modification by the Introduction of Chelate Fragment

... chemical structure, the size of the crown ring, the nature of donor atoms of the ring and pendent groups it is possible to attain the high selectivity towards almost any metal ... See full document

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