marks of the medieval ars moriendi. And when servants strip the cardinal’s body for burial, they are surprised to find a shirt of hair under his fine linen (Cavendish 1962:186–187). In contrast to Hall’s arrogant and seditious Roman prelate, Cavendish’s Wolsey is a more human figure: flawed, fallen but ultimately redeemed – and redeemed at least in part through stereotypically Catholic religious practices such as the wearing of a hair-shirt. While Cavendish’s Life was not printed until 1641 (and even then only in a highly censored version), the text circulated in manuscript in the second half of the 16th century, and elements of Cavendish’s portrayal of Wolsey appear in other, more widely distributed accounts. John Stow’s Annales of England (1592) reprints many of Cavendish’s narratives of Wolsey’s journeys, banquets, servants and household arrangements. The authors of Holinshed’s Chronicle, which as we have already seen borrows some criticisms from Hall, followed Cavendish in part for their narrative of Wolsey’s fall, and William Shakespeare and John Fletcher borrowed from both Hall’s and Cavendish’s narratives in writing their play Henry VIII (All Is True). It is perhaps artificial to speak of a ‘Hall narrative’ and a ‘Cavendish narrative’ about Wolsey, because few later writers borrowed only from one or the other of these authors; because Hall and Cavendish agree with each other on some points and because there was also a flourishing tradition of Catholic recusant writing about Wolsey. However, for the purposes of examining later depictions of Wolsey, it is not unhelpful to think of a continuum running between Hall’s unflattering portrayal and Cavendish’s sympathetic biography, a continuum on which it then becomes possible to locate individual histories, plays and video productions. It is this continuum that will structure the analysis that follows.
One striking feature of viruses with RNA genomes is the modification of the host membrane structure during early infection. This process requires both virus- and host-encoded proteins; however, the host factors involved and their role in this process remain largely unknown. On infection with Tobacco mosaic virus (TMV), a positive-strand RNA virus, the filamentous and tu- bular endoplasmic reticulum (ER) converts to aggregations at the early stage and returns to filamentous at the late infectious stage, termed the ER transition. Also, membrane- or vesicle-packaged viral replication complexes (VRCs) are induced early dur- ing infection. We used microarray assays to screen the Arabidopsis thaliana gene(s) responding to infection with TMV in the initial infection stage and identified an Arabidopsis gene, PAP85 (annotated as a vicilin-like seed storage protein), with upregu- lated expression during 0.5 to 6 h of TMV infection. TMV accumulation was reduced in pap85-RNA interference (RNAi) Arabi- dopsis and restored to wild-type levels when PAP85 was overexpressed in pap85-RNAi Arabidopsis. We did not observe the ER transition in TMV-infected PAP85-knockdown Arabidopsis protoplasts. In addition, TMV accumulation was reduced in PAP85- knockdown protoplasts. VRC accumulation was reduced, but not significantly (P ⴝ 0.06), in PAP85-knockdown protoplasts. Coexpression of PAP85 and the TMV main replicase (P126), but not their expression alone in Arabidopsis protoplasts, could induce ER aggregations.
However, as with the UKLS study this analysis has a number of weaknesses. The reductive nature of the model, primarily considering the survival benefit of earlier stage lung cancer diagnosis with a quality of life adjustment for the life years gained with screening, implies a limited definition of benefit of the programme, failing to reflect the potential benefits of other factors including COPD diagnosis, or smoking cessation (advice given to all attendees). Furthermore, the analysis is limited by the scale and scope of the pilot, failing to reflect the impact of the screening past the first follow up at 3 months or whether a different screening criteria or approach in the same population would be more cost- effective.
The care management content in the SBCS was prepared by two educators in the nursing school who had doctoral degrees in surgical nursing, and was further evaluated by four specialist instructors with similar doctorates in surgical nursing. In the SBCS, pre-postoperative care management topics were explained using textual information, images, flow charts, tables, sample cases and videos. There is no comparable simulation available in Turkey. In the first stage of the project, a randomized controlled trial was conducted using the SBCS to teach pre-postoperative care management to second-year nursing undergraduate students (Durmaz, Dicle, Cakan, Cakır, 2012).
All stage and screen media have the potential to reshape our perceptions of reality, even if just for a brief moment; that is why they are so popular. They encourage an audience to momentarily suspend disbelief at the drama being played out. Music plays an important role in stirring emotions and situating the listener within a specific context, largely via specific codes that have become ingrained in western cinematic traditions. For historical—or historicizing—music, the diverse and multifarious uses of the musical past can challenge traditional notions of ‘authenticity’, with the fidelity to the medium being, arguably, more important than history itself. v For example, vocal music
There should be continued screening even at old age, especially unless routine screening is followed systematically. There is a need for proper awareness about cervical cancer, its precancerous lesions, importance of routine screening and motivation at grass root level for preventing women falling victims of a cancer that can very well be prevented or detected at an early stage. Community health workers and women volunteers can play a major role in removing the barriers in undergoing PAP test and women empowerment as proven in other studies conducted in India. 23,24 Tertiary centers need active coordination, with secondary and primary health care facilities, to mobilize women to undergo screening, if the latter’s facilities and infrastructure are inadequate. Also, there must be strong campaigns and advertisements through media like for breast cancer and HIV-AIDS for health education regarding cervical cancer. Males of the family should be educated as well regarding the existence of cervical cancer and the methods of its early detection and prevention.
The next stages for this work would be to further the extendable FoldWatch concept by making a functional prototype for user testing. This could be produced using Smart Material Alloy (SMA) wires such as in the Morphee Couture prototype , and combining with thin- film electro-luminescence  and Flexy technologies  or OLED [26, 51] – however, the materials used must make use of full closure , i.e. bend completely back on themselves. With currently available hardware, we believe it would be possible to make a functional prototype. This would require materials testing, stress testing of joining structures and programming to change screen views to map onto the extended areas in user-friendly fashion. With a working prototype in place, there would also then be the opportunity to look at specific application functions for foldable smartwatches, such as the tri-map view scenario, or investigating if this type of screen extension is of use for fitness bands. With the utilisation of a working model, we can then explore the potential of the interaction types and folds to generate agreement ratings to best develop the device to user-specifications . The addition of physiological data or 3D projected objects would also be an exciting avenue of investigation for subsequent work. The FoldWatch concept offers the potential for extended interaction styles, novelty in application usage, and improving the overall user experience for smartwatches, we therefore hope to continue this exciting line of work and extend our knowledge in this area.
was used to find the center of the beam. Also, sapphire glass was preferred for the glass of the moving beam screen due to its radiation endurance. The setup is shown in Fig. 14. This screen is essential for alignment of the mechanical installation of the accelerators to observe the beam profile at different stages. In the METU-DBL pretest setup, the size of the proton beam can be measured as a function of a magnetic field by using a quadrupole scan technique  with a fixed beam screen. The quadrupole
The internet Tailored PDS (TPDS) group participants received messages about screening designed to either motivate a change in attitude, where this was not con- sistent with screening participation, or reinforce existing attitudes, where these were consistent. Messages pertain- ing to each PHM variable were presented in an order that accorded with the results of previous research. This prior research had demonstrated that addressing a specific subset of PHM variables at specific stages was associated with movement to a higher stage of readiness to screen as measured by the PAPM [28-30]. In our study the two PHM variables that Myers and colleagues  established were most strongly linked to movement between specific PAPM decision stages were given prior- ity and presented as the first two motivating and/or reinforcing messages. The aim of message order place- ment was to exploit the primacy effect whereby informa- tion that is important for medical decision-making is presented first in order to ameliorate problems with short term memory . The construction and delivery of the tailored messages has been described previously in greater detail . In addition to receiving these Table 1 Study interventions by phase and arm a
A Product Development is widely recognized as a key to corporate prosperity. A new product development needs conceiving idea, screened for its technical, commercial and strategic fits, selected for marketing, developed to stand against the competition, tested for its durability and launched to the customer market.To create the new generation product, a design team goes through product development process steps again. Starting with a product idea, the team moves through several stages to generate all the details and documents needed to get the product built. A New Product Development (NPD) process goes through several stages as shown in Figure 3. The five step stage gate process explained in figure 3 clearly shows the steps involved in each stage and decision making. However, as this product has not been developed by the team before, new risks and uncertainties are introduced and often additional information is documented and shared with manufacturing.
The most exciting potential applications of ctDNA analysis are in early stage cancer, detecting residual disease to predict who is at risk of relapse, and using ctDNA assays to screen for cancer in unaffected people. In early stages of cancer the level of ctDNA in circulation is very low mainly due to low tumour bulk, and the potential uses of ctDNA in these early cancer settings has been facilitated by rapid development of ctDNA analysis techniques that allow detection of very low levels of ctDNA with high specificity, using PCR based techniques (2,3) and error corrected next generation sequencing techniques (NGS)(4) .
Figure 2 shows the general scheme of the selection procedure. In the design level the designer constructs the product with all the design requirements. They are the input data for the process selection procedure and are compared to each of the process attributes. The first stage of the selection process procedure is called screening. The aim of this stage is to eliminate the material/design requirements/process combinations that are clearly not viable. At this level, attribute-based selection using range-type attributes is usually performed. Screening can take place for all the design requirements at a low level of detail. Simple coupling between the attributes and the requirements can be captured by one-to-one matching or paired- parameter matching . The database may be organised conventionally, such as in the form of data sheets and/or different technological windows, which can be easily transformed into if-then rules for additional computer-based screening. The result of this selection stage is a set of processes that are able to manufacture a product out of a certain material under its design requirements. This information passes to the subsequent stage of selection, but could also be useful for the technologist and the designer. They can find a better solution for the design of the product by requirements reduction and material swap, which may incorporate less expensive manufacturing processes. The viable combinations of process/material and the design requirements are calculated in the next stage of selection procedure: parameters definition. This potential set may still contain processes that cannot physically form the product. One of the main reasons for this is the correlation obnaanja, ki jo zahteva konstrukcija. Te funkcije
Abstract: Colorectal cancer (CRC) is the third most common cancer in the UK. The English National Health Service (NHS) Bowel Cancer Screening Program (BCSP) was introduced in 2006 to improve CRC mortality by earlier detection of CRC. It is now offered to patients aged 60–74 years and involves a home-based guaiac fecal occult blood test (gFOBt) biennially, and if positive, patients are offered a colonoscopy. This has been associated with a 15% reduction in mortality. In 2013, an additional arm to BCSP was introduced, Bowelscope. This offers patients aged 55 years a one-off flexible sigmoidoscopy, and if several adenomas are found, the patients are offered a completion colonoscopy. BCSP has been associated with a significant stage shift in CRC diagnosis; however, the uptake of bowel cancer screening remains lower than that for other screening programs. Further work is required to understand the reasons for nonparticipa- tion of patients to ensure optimal uptake. A change of gFOBt kit to the fecal immunochemical tests (FIT) in the English BCSP may further increase patient participation. This, in addition to increased yield of neoplasia and cancers with the FIT kit, is likely to further improve CRC outcomes in the screened population.
There were occasionally however, choreographic changes made in the studio on the day, due mostly to unexpected practical challenges and problems which could never have been predicted. On those occasions, the fact that the planning had been so thorough, rather than restricting change, confirmed the notion of 'the freedom of self-discipline' - that the detailed planning had ensured the process was so well-tuned and efficient (to the extent that we achieved, on average, a 'set-up' every 33 minutes, in contrast to the accepted blue-screen set-up time of one every 3 hours), that we were so in control artistically, technically and organisationally, and the foundation of the work so strong, that within the envelope of constraints we were able to create new opportunities - whether out of necessity or desire. Thus the notion of spontaneity, enjoyment and creative satisfaction which one associates with the creation of art, whilst very contained within strict parameters, was not entirely lost by a process so highly technical. The sense of creative satisfaction in this case was significant in a very different way - perhaps the process was more satisfying intellectually, but the
Thomas Paine “Common Sense” & American Crisis - 40 - Compiled By: John Paul Tabakian so; and as I mean not to conceal the name of any true friend when there shall be occasion to mention him, neither will I that of an enemy, who ought to be known, let his rank, station or religion be what it may. Much pains have been taken by some to set your lordship's private character in an amiable light, but as it has chiefly been done by men who know nothing about you, and who are no ways remarkable for their attachment to us, we have no just authority for believing it. George the Third has imposed upon us by the same arts, but time, at length, has done him justice, and the same fate may probably attend your lordship. You avowed purpose here is to kill, conquer, plunder, pardon, and enslave: and the ravages of your army through the Jerseys have been marked with as much barbarism as if you had openly professed yourself the prince of ruffians; not even the appearance of humanity has been preserved either on the march or the retreat of your troops; no general order that I could ever learn, has ever been issued to prevent or even forbid your troops from robbery, wherever they came, and the only instance of justice, if it can be called such, which has distinguished you for impartiality, is, that you treated and plundered all alike; what could not be carried away has been destroyed, and mahogany furniture has been deliberately laid on fire for fuel, rather than the men should be fatigued with cutting wood. There was a time when the Whigs confided much in your supposed candor, and the Tories rested themselves in your favor; the experiments have now been made, and failed; in every town, nay, every cottage, in the Jerseys, where your arms have been, is a testimony against you. How you may rest under this sacrifice of character I know not; but this I know, that you sleep and rise with the daily curses of thousands upon you; perhaps the misery which the Tories have suffered by your proffered mercy may give them some claim to their country's pity, and be in the end the best favor you could show them.
The life of Cardinal ThomasWolsey, lord chancellor of England from 1515 to 1529, has inspired no small number of literary, historical, and dramatic retellings. A comprehensive study of these texts remains to be written, but this article seeks to make a start by examining how Tudor writers portrayed the cardinal’s response to his deposition and subsequent disgrace. For some authors, Wolsey’s fall only made him more proud, and he began to act erratically and disloyally, confirming the wisdom of the king’s decision to relieve him of office. For others, deposition moved Wolsey to become philosophical and penitent, and some such writers depict a cardinal who at the end of his life underwent nothing short of a conversion. This article traces both of these historiographical trajectories from their origins in writings of the late 1540s and 1550s through a range of late Tudor chronicle accounts. Elements of both narratives about the cardinal appear, prominently if not always congruously, in one of the best-known theatrical works about the events of the reign of Henry VIII, the play King Henry VIII (All Is True) by William Shakespeare and John Fletcher. Understanding the interrelationships between the Tudor texts presented here is essential to grasping later portrayals of Wolsey and his contemporaries.
Book Review Thomas & Thomas Legal Times of the Use of Chemical and Biological Weapons SMU Law Review Volume 25 | Issue 2 Article 15 1971 Book Review Thomas & Thomas Legal Times of the Use of Chemical[.]