[PDF] Top 20 High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance)

... From this, it follows that the relative risk associated with oral contraceptive use is the same for homozygous women äs for women with the other genotypes (under the reasonable assumptio[r] ... See full document

... 18 Rosendaal FR, Koster T, Vandenbroucke JP, Reitsma PH High risk of thrombosis m patients homozygous for factor V Leiden 30 (activated protein C resistance) Blood 1995, 85 1504-8. 19 Ri[r] ... See full document

... venous thrombosis (DVT) and other throm- botic events also have emerged as major adverse ...the risk of VTE to 50% in those with ...increased risk of thrombosis in patients with MM is ... See full document

... arterial thrombosis, with deep vein thrombosis being the most ...important factor of thrombosis, although the endothelial injury itself cannot completely explain the hypercoagulable state of ... See full document

... The risk of pulmonary hypertension is high in our cohort ...in patients with thrombophilia vs 10% in ...by activated protein C (APC) resistance which is caused by mutation ... See full document

... of patients who present with deep vein thrombosis (DVT) or pulmonary embolism have this ...The risk of developing a clot in a blood vessel depends on whether a person inherits one or two copies of ... See full document

... among patients treated with highly active antiretroviral therapy (HAART), protean haematologic manifestation including decreased activities of some natural anticoagulant glycoproteins such as protein ... See full document

... our local APC resistance lest After stratification of the normal- ized APC-SRs mto quartiles, we observed that 45% of the subjects m the lowest quartile (n-APC-SR <0 92) had high fact[r] ... See full document

... H van der Velden PA Reitsma PH Mutation in blood coagulation factor V associated with resistanceto activated protein C Nature 1994,369 64-67 11 HalbmayerWM,HaushoferA,SchonR,FischerM The[r] ... See full document

... “activated protein C” (APC). As a result, Factor V Leiden would not be inactivated, remains activated in the prothrombinase complex and consequently, more thrombin will be ... See full document

... We found no differences m the prevalence of inher- ited nsk factors for venous thrombosis, mcluding factor V Leiden, prothrombm 20210A allele, and protem C, protem S, and antithrombin de[r] ... See full document

... genetic risk factors for familial thrombophilia in children with arterial and venous ...(22%) patients with arterial vascular insults and 5 of 36 (14%) with venous thrombosis showed Lp (a) ... See full document

... In this way the role of a deficiency of protein C, protein S or antithrombin and of APC (activated protein C) resistance, elevated von Willebrand factor and factor VIII:c levels, hyperho[r] ... See full document

... We propose that anticoagulant synergism between APC and AT III in the regulation of PTase could occur as schemati- cally presented in Fig. 7. Upon exposure of procoagulant phos- pholipid membrane binding sites, FV ... See full document

... Also, when we excluded subjects who had known genetic risk factors for thrombosis (e.g., protein C or S deficiency, antithrombin deficiency, the factor V Lei- den mutation, orthe prothro[r] ... See full document

... When patients present with symptoms of nerve root compression, sciatica, exercise- induced numbness, or lower back pain with no other patho- logic explanation, full radiologic workup is used to assess epidural ... See full document

... Methods: By mutagenesis of the vitamin K-dependent Gla domain of APC, we have recently created an APC variant having enhanced anticoagulant activity due to increased affinity for negatively charged phospholipid ... See full document

... We sum- marize the findings from a study of myocardial infarction in young women that suggests that the joint effects of a prothrombotic risk factor, factor V Leiden, and other risk fac-[r] ... See full document

... cancer patients in the Leiden University Medical Centre Department of Clinical Oncology received a cen- tral venous catheter for either repeated administration of chemotherapy with sclerosing agents known ... See full document

... This population-based, case-control study confirms that, among unselected patients, the prevalence of a (hereditary) protein C deficiency and of lowered protein S and antithrom- bin plas[r] ... See full document