[PDF] Top 20 Tissue engineering and regenerative approaches to improving the healing of large bone defects

... stimulate bone regeneration (Jeon et ...by bone stimulating molecules are typically not unique to bone formation, and molecules are often selected based on their ability to induce heterotopic ... See full document

... the healing of diseased, damaged and traumatized bone ...typical tissue engineering application, osteogenic cells would be harvested from the patient and seeded on a synthetic porous ... See full document

... cortical bone and show a similar bone remodeling and turnover rate as humans, but have a plexi- form bone structure with few Haversian canals unlike the human bone [33, ...human bone ... See full document

... FTE approaches including the use of growth factors, gene transfer/gene therapy, cell therapy, and extracellular matrix ...ACL defects[90-94], and all have shown an increased vascularization, increased ... See full document

... of tissue engineering and regenerative ...of bone tissue en- gineering ...skull defects in SD rats by bone marrow mesenchymal stem cell sheets combined with calcined ... See full document

... Allogenic bone has been used but this has minimal osteoinductive capacity, is possibly immunogenic, has a potential for disease transmission and is minimally replaced by new ...enhancing bone formation and ... See full document

... In order to fully understand the nature of these syner- gistic ECM interactions, researchers have performed high throughput analysis of mixtures of individual ECM molecules on stem cell fates [100, 101]. In these ... See full document

... of tissue engineering and regenerative medicine is ...of tissue engineering and regenerative medicine still remains a ... See full document

... Safety and efficacy of skin substitutes are regulated in the USA by the US Food and Drug Administration (FDA). Biologic skin substitutes have increased in com- plexity from models that replace either dermis or epider- ... See full document

... In this study, SVT in situ gels were successfully prepared by our group. The drug content of the prepared gels was found to be in the range between 89% and 92%. The pH value was in the range between 6.5 and 7.0. The ... See full document

... new bone could spread on the surface of WH/chitosan and grow into the implants, presenting closer contact between new bones and implants ...formed bone tissue were found in HAP/chitosan group, with ... See full document

... • Nanoparticles: microscopic tumor-destroying genes may possibly be transported to certain sites, directed with great precision to destroy the genetic information of tumors, with the aim of inactivating the target cells ... See full document

... HT tissue were able to support ectopic mineralization and immature bone ...ectopic bone formation through the ingrowth of vessels and subsequent delivery of pro- genitor cells and growth ... See full document

... Transdifferentiation requires source cells to be con- verted into reprogrammed cells. The source cells used in transdifferentiation studies vary, but, generally, the cells are readily available and found in abundance in ... See full document

... debate on the regenerative effects of these cells has been introduced. It is still not clear if ASCs show their main effects directly by differentiating into mature cells (e.g. osteocytes) at the site of ... See full document

... enhance healing in delayed unions, nonunions, ostoectomies, arthrodesis, multifrag- mentary fractures and to replace bony loss resulting from neoplasia or cysts ...Autogenous bone graft is commonly used and ... See full document

... calvarial defects were randomized into four groups (15 rats/group) as follows: a control (CS) group in which the calvarial defect was treated with an Osteoset bone graft alone; a CS/PLGA group treated with ... See full document

... any bone banks. This has shown to contribute to improving safety in human transplantation even though they have adverse effects on incorporation which is not much disturbed in our study of cancellous ... See full document

... matrix tissue and thus inhibit healing [5, 33, ...though, tissue regeneration is equally reliant on the interactions and cross-talk between surrounding cells and ...of tissue healing ... See full document

... [3] Edwards PC, Mason JM. Gene-enhanced tissue engineering for dental hard tissue re‐ generation: (1) overview and practical considerations. Head Face Med 2006;2:12. [4] Forscher C, Mita M, Figlin R. ... See full document