[PDF] Top 20 A Novel Herpes Simplex Virus Type 1 Transcript (AL-RNA) Antisense to the 5′ End of the Latency-Associated Transcript Produces a Protein in Infected Rabbits
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A Novel Herpes Simplex Virus Type 1 Transcript (AL-RNA) Antisense to the 5′ End of the Latency-Associated Transcript Produces a Protein in Infected Rabbits
... infection, herpes simplex virus type 1 (HSV-1) establishes a lifelong latent infection in sensory neurons of the trigeminal ...ganglia. Latency-associated ... See full document
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Analysis of Protein Expression from within the Region Encoding the 2.0-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 1
... and latency, while a second promoter was active in tissue culture cells, ...latently infected cells, while the ...LAT-GFP virus did not express detectable levels of GFP either in infected-cell ... See full document
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The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine.
... 39 end of the ...59 end of the ...latently infected neurons ...a novel RT-PCR technique, we have identified the branch point of the ...and infected tissue culture cells as well as ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Expression Protects Trigeminal Ganglion Neurons from Apoptosis
... with herpes simplex virus type 1 (HSV-1), an immune response is initiated resulting in significant infiltration of CD8 ⴙ T ...the latency-associated ... See full document
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During Herpes Simplex Virus Type 1 Infection of Rabbits, the Ability To Express the Latency-Associated Transcript Increases Latent-Phase Transcription of Lytic Genes
... latently infected rabbits, chromatin immunoprecipi- tation (ChIP) was performed using anti-dimethyl H3 K4 (Mil- lipore) on TG from rabbits latently infected with 17syn ⫹ , fol- lowing the ... See full document
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The Stable 2.0-Kilobase Intron of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Does Not Function as an Antisense Repressor of ICP0 in Nonneuronal Cells
... a protein that functioned, directly or indirectly, as a viral transcriptional ...a protein. The LAT is associated with the polyribosome fraction of lytically and latently infected cells (20), ... See full document
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A 437-base-pair deletion at the beginning of the latency-associated transcript promoter significantly reduced adrenergically induced herpes simplex virus type 1 ocular reactivation in latently infected rabbits.
... alphaherpesvirus herpes simplex virus type 1 (HSV-1) can establish lifelong latency in the nervous system following an acute ...of herpes latency is ... See full document
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A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... tion transcript termination signal inserted at various sites along the primary transcript, we present evidence that the epineph- rine-induced reactivation phenotype resides primarily within the 5 9 ... See full document
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Interactions between Herpesvirus Entry Mediator (TNFRSF14) and Latency-Associated Transcript during Herpes Simplex Virus 1 Latency
... LAT-encoded protein that regulates the latency- reactivation cycle has been identified, suggesting that LAT regu- lates the latency-reactivation cycle by exerting its effect as an RNA molecule rather ... See full document
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A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation
... experiment 1 were greatly handicapped by the fact that only three of the ...Table 1), both of which contained more surviving rabbits in most ...in rabbits latently infected with ...from ... See full document
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Mutations in the 5' end of the herpes simplex virus type 2 latency-associated transcript (LAT) promoter affect LAT expression in vivo but not the rate of spontaneous reactivation of genital herpes.
... latently infected guinea pig ...in 1 ml of RNA Stat-60 with a Tekmar ...About 1 ng of sample RNA in 5 m l was added to each tube. From tubes 1 to 4, 5 m l of competitor RNA was ... See full document
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Herpes Simplex Virus Type 1 2-Kilobase Latency-Associated Transcript Intron Associates with Ribosomal Proteins and Splicing Factors
... in infected cells, as shown in ...ICP27 protein (15, ...in infected cells compared to unin- fected cells in our experiments, in contrast to -actin mRNA levels and distribution, the 28S ribosomal RNA ... See full document
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Analysis of the 2-kilobase latency-associated transcript expressed in PC12 cells productively infected with herpes simplex virus type 1: evidence for a stable, nonlinear structure.
... gene transcript was observed (results not ...9 end of the tran- script was performed to identify a putative branch point at which the extension would be ...2 1 to 2 23 relative to the 3 9 end ... See full document
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Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections.
... same 5 9 ends as the wild-type ...the 5 9 ends of the 2-kb LAT were the same ( 6 2 nt) regardless of whether it was made by wt, LAP1, LAP2 or the double LAP11LAP2 deletion virus ...59 ... See full document
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The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency.
... natural antisense mechanism to down regulate viral gene tran- scription in neurons ...wild type in its ability to reactivate in a timely manner in an in vitro cocultivation assay, as well as in ... See full document
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Three Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutants with Distinct and Asymmetric Effects on Virulence in Mice Compared with Rabbits
... ocularly infected for each time point shown ...infectious virus was determined individually for each TG at each time ...of virus in the brains of the same mice were similarly ...day 5 p.i. ... See full document
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The Latency-Associated Transcript Gene Enhances Establishment of Herpes Simplex Virus Type 1 Latency in Rabbits
... parental virus for ⌬LAT-EGFP was dLAT2903, a mutant of HSV-1 strain McKrae containing a ...the 5⬘ end of the primary 8.3-kb LAT transcript (LAT nucleotides ⫺161 to ⫹1667) in both copies ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... latently infected ganglia by ...latently infected ganglia essentially as originally described by Katz et ...were infected as above and after at least 30 days ...and 5⬘ end of the 2-kb ... See full document
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In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter.
... the infected neurons segregate into two distinct ...latently infected and that the productively infected neurons shut off the LAT promoter through autoregulation by the ICP4 protein (1, ... See full document
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Tissue-Specific Splicing of the Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Intron in LAT Transgenic Mice
... of latency between the transgenic and nontransgenic mice was ...were infected with an HSV-1 strain KOS-based LAT mutant reac- tivated this mutant more efficiently than nontransgenic ... See full document
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