[PDF] Top 20 Translation of β Globin m RNA in β Thalassemia and the S and C Hemoglobinopathies
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Translation of β Globin m RNA in β Thalassemia and the S and C Hemoglobinopathies
... hemoglobin S and hemoglobin C, the mutant b-chain is produced in smaller amounts than normal b A ...Defective m-RNA translation has been suggested as a possible cause of decreased ... See full document
10
Genomic approaches to identifying targets for treating β hemoglobinopathies
... tion velocity—a surrogate for pulmonary hypertension [27]—stroke [28] and systemic blood pressure—a surro- gate for silent ischemic infarct [29]. The results for biliru- bin and cholelithiasis were robust but expected, ... See full document
13
Investigation of RFLP Haplotypes β- Globin Gene Cluster in Beta-Thalassemia Patients in Central Iran
... reported β-globin gene cluster haplotypes association with a common mutation in Esfahan province in ...beta- thalassemia mutations experienced positive selection pressure, probably because of the ... See full document
7
Hemoglobin Messenger RNA from Human Bone Marrow ISOLATION AND TRANSLATION IN HOMOZYGOUS AND HETEROZYGOUS β THALASSEMIA
... beta thalassemia and sickle cell trait, as well as from a patient with normal hemoglobin synthesis but with an elevated reticulocyte count secondary to hereditary ...beta globin chains synthesized was ... See full document
12
Click here to download PDF version of the article !
... of hemoglobinopathies, which has become a major genetic and public health problem in both tribal and nontribal ...of hemoglobinopathies provide most valuable data for analysis with respect to introspection ... See full document
9
β Thalassemia in the American Negro
... of globin synthesis was decreased in only 15 heterozygotes, whereas in the other 11, b/a globin synthesis was in the normal range or was slightly ...of globin synthesis in the peripheral blood is ... See full document
8
AHSP: a novel hemoglobin helper
... Recently, the small protein α hemoglobin–stabilizing protein (AHSP) was identified and found to specifically bind α-globin, stabilize its structure, and limit the toxic effects of excess α-globin, which are ... See full document
5
A validated cellular biobank for β thalassemia
... mostly β-thalassemic, expanded and cryopre- served. Expression of globin genes was analyzed by real time ...from β-thalassemia ...hemo- globin production and exposed to fetal hemoglobin ... See full document
13
HPLC Studies in Thalassemia and Other Hemoglobinopathies
... ABSTRACT: Hemoglobinopathies are serious public health problem in the ...different hemoglobinopathies. A total of 142 cases of different hemoglobinopathies were enrolled in this ...II ... See full document
5
Spectrum of β-thalassemia Mutations in Iran, an Update
... of β-TM without significant enhancement in Hb F level ...(γ) globin gene polymorphism (presence of G nucleotide rather than A nucleotide at 5'HS4-LCR palindromic polymorphic site), co- inheritance of α ... See full document
13
β-Thalassemia and ocular implications: a systematic review
... PXE-like fundus changes are a consistent finding in nu- merous studies. The term PXE-like syndrome has been used to describe vascular, dermal and ocular alterations characteristic of PXE that occur secondary to other ... See full document
13
Molecular Study on β-Thalassemia Patients in Iraq
... the β- globin gene, splicing procedures and translation of β - globin gene mRNA, resulting in either absence or reduction of synthesis of β -globin chains [4] ...reduced ... See full document
6
Novel Meta-Heuristic Model for Discrimination between Iron Deficiency Anemia and Β-Thalassemia with CBC Indices Based on Dynamic Harmony Search (DHS)
... There are several different, task-specific blood cell types, such as white blood cells (WBCs), red blood cells (RBCs), and platelets. A red blood cell transmits oxygen to all cells of the body and receives the CO2 ... See full document
10
Hb Knossos (HBB: c.82G > T), β-globin CD 5 (−CT) (HBB: c.17_18delCT) and δ-globin CD 59 (−a) (HBD: c.179delA) mutations in a Syrian patient with β-thalassemia intermedia
... Direct DNA sequencing of the entire human HBB and HBD genes was done on an ABI PRISM 310-DNA Analyzer (Applied Biosystem, Foster City, CA, USA) as previously reported [14, 15]. The genotyping of HBB gene was determined ... See full document
5
Click here to download PDF version of the article !
... The β- thalassemia incidence in the Khuzestan province is between ...entire β -globin gene to localize the mutation, followed by DNA sequencing for ...(127 thalassemia patients and 127 ... See full document
7
Synthesis of Globin Chains in Sickle β Thalassemia
... sickle thalassemia, there was no evidence of a significant excess of a-chains in the red cells of the bone marrow which could contribute to the hemolysis and ... See full document
7
Original Article β-thalassemia for translating human β-globin gene and RNA interference of α-globin gene expression by lentivirus vectors
... human β-globin, thus, it is a very good tool to study the transition mechanism of γ-globin to α-globin in the devel- opment ...of β-globin mRNA in the K562 cells by reducing ... See full document
10
Understanding globin regulation in β thalassemia: it’s as simple as α, β, γ, δ
... The specific role of the region between the human γ- and δ-globin genes (termed inter- genic γ–δ sequences) in regulating normal hemoglobin switching and potential reacti- vation of HbF production in adult cells ... See full document
5
Equal synthesis of α and β globin chains in erythroid precursors in heterozygous β thalassemia
... Equal synthesis is probably due both to a decrease in a-chain synthesis and an increase in b-chain synthesis in bone marrow erythroid cells and may contribute to the absence of overt hem[r] ... See full document
5
Premarital Screening of Beta Thalassemia Minor in north-east of Iran
... essential. Thalassemia is found in some 60 countries with the highest prevalence in the Mediterranean region, parts of North and West Africa, the Middle East, the Indian subcontinent, southern Far East and ... See full document
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