[PDF] Top 20 Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008
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Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008
... human Galectin-1 ELISA (used in Additional file 1: Figure S1) and an ELISA made as follows (used in ...taining Galectin-1 protein was produced in E-coli Rosetta from pMCSG-7-Gal1 ... See full document
15
FPGS rs1544105 polymorphism is associated with treatment outcome in pediatric B-cell precursor acute lymphoblastic leukemia
... with CC genotype. Panetta et al. reported that FPGS activ- ity of rs1544105 CC carriers was 2.6 times higher than CT and TT carriers in a St Jude ALL cohort [15]. As FPGS mRNA expression correlates with activity [8], ... See full document
8
Decitabine demonstrates antileukemic activity in B cell precursor acute lymphoblastic leukemia with MLL rearrangements
... combined treatment. E is calculated as follows: E = (A + B) − (A*B), where A and B are the relative inhibition of single agent A and ... See full document
13
Recombinant human CD19L sTRAIL effectively targets B cell precursor acute lymphoblastic leukemia
... B cell precursor acute lymphoblastic leukemia (BPL) is the most common form of cancer in children and adolescents ...the treatment of BPL is to cure patients who have ... See full document
14
An adult B-cell precursor acute lymphoblastic leukemia with multiple secondary cytogenetic aberrations
... myeloid leukemia (CML), indicating that other factors than BCR-ABL1 are involved in its development and progression ...+ precursor-B-ALL is highly ag- gressive, frequently resistant to chemotherapy ... See full document
5
SYK as a New Therapeutic Target in B Cell Precursor Acute Lymphoblastic Leukemia
... in B-lineage leukemia/lymphoma cells— prompts the hypothesis that rationally designed inhibitors targeting SYK may overcome the resistance of malig- nant B-lineage lymphoid cells to apoptosis and ... See full document
8
B-cell precursor acute lymphoblastic leukemia and stromal cells communicate through Galectin-3
... between B-cell precursor acute lymphoblastic leukemia (pre-B ALL) cells and stromal cells in the bone marrow that provide microenvironmentally-mediated protection against ... See full document
17
Immunotargeting relapsed or refractory precursor B-cell acute lymphoblastic leukemia – role of blinatumomab
... In Phase II trials, blinatumomab was evaluated in patient cohorts with primary resistant or relapsed B-lineage ALL (R/R ALL), patient cohorts with poor outcome irrespec- tive of the therapeutic regimen applied ... See full document
12
DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia
... for Treatment of Childhood Relapse ALL (IntReALL) into standard risk (late relapse and early not isolated bone marrow iBM) or high risk (early iBM and very early relapse) groups ... See full document
7
The Role of PU.1 and Spi-B in B Cell Acute Lymphoblastic Leukemia
... pediatric B cell acute lymphoblastic leukemia, representing 25% of the ...human leukemia cell lines AT-2 and REH, which express ETV6-RUNX1, suggested that SPIB was one of ... See full document
88
T cell senescence and CAR-T cell exhaustion in hematological malignancies
... Treg cell mechanism of forcing T cells into senescence ...Treg cell accumulations in hematological malignancies such as acute myeloid leukemia (AML), acute lymphoblastic ... See full document
9
Acute B-Cell Lymphoblastic Leukemia/Acute B-Cell Lymphoblastic Lymphoma Presenting as Bilateral Breast Masses
... Metastases to the breast and axilla are rare and account for approximately 2% of all mammary malignancies [1,2]. The most common metastatic lesion to involve the breast is a metastasis from a contralateral mammary cancer ... See full document
5
Intrinsic radiation resistance of primary clonogenic blasts from children with newly diagnosed B cell precursor acute lymphoblastic leukemia
... resistance at the level of B-lineage LPC. The highest CD34 expression group (> or = 75% positivity) had 1.4-fold higher SF2 (P = 0.05) and twofold lower alpha values (P = 0.06) than the lowest group (< 30% ... See full document
9
Author Correction: Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
... New GWAS samples. UK GWAS II consisted of 1021 BCP-ALL cases recruited to Medical Research Council UK ALL-2003 (2003–2011) (683 cases; 307 females, mean age: 5.9 years) and ALL-97/99 trials 40,41 (338 cases, 160 females, ... See full document
9
Pediatric donor cell leukemia after allogeneic hematopoietic stem cell transplantation in AML patient from related donor
... advances, leukemia relapse remains the main prob- lem that reduces the cure rates after alloHSCT ...leukemic cell reappears at any site in the ...of treatment, late relapse is not common and occurs ... See full document
7
<p>T-lymphoid/myeloid mixed phenotype acute leukemia and early T-cell precursor lymphoblastic leukemia similarities with <em>NOTCH1</em> mutation as a good prognostic factor</p>
... for Treatment of Childhood Lymphoblastic Leukemia (GBTLI-ALL 99/09) or to ALL Berlin- Frankfurt- Münster (BFM-ALL 95 and 2002) ...cation treatment with MTX 2 g/m 2 ×4, 6-MP and MADIT and ... See full document
11
Composite Multifocal Basal Cell carcinoma and Precursor B Acute Lymphoblastic Leukemia: Case report
... of small mature lymphocytes were noted inbetween the invasive solid masses of BCC. A wide panel of immuno- histochemistry was performed (Table 1 and fig. 3, 4, 5, 6, 7, 8) and accordingly the case was diagnosed as ... See full document
7
Clinical use of blinatumomab for B-cell acute lymphoblastic leukemia in adults
... The treatment is administered as a CIV infusion through a dedicated lumen at a constant rate using an infu- sion ...to treatment initiation in each cycle, prior to the dose escalation in cycle 1, and ... See full document
10
Face Bones Involvement and Relapse in a Case of Childhood Acute Leukemia
... local control, patient received radiotherapy of the right maxilla according to radiotherapist recommendation. Ten days after initiation of the chemotherapy, swelling, pain and local tenderness resolved. Tertiary relapse ... See full document
5
Prediction of outcomes by early treatment responses in childhood T-cell acute lymphoblastic leukemia: a retrospective study in China
... From January 2003 to December 2012, 74 consecutive patients aged 15 years or younger with newly diagnosed T-ALL were enrolled in the Department of Pediatric, In- stitute of Hematology and Blood Diseases Hospital, Peking ... See full document
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