[PDF] Top 20 Tumor Suppressor p53 Stimulates the Expression of Epstein-Barr Virus Latent Membrane Protein 1

... ABSTRACT Epstein-Barr virus (EBV) is associated with multiple human ...EBV latent membrane protein 1 (LMP1) is required for the efficient transformation of primary B ... See full document

... miR-183-96-182 Expression by Epstein-Barr Virus Latent Membrane Protein 1 Lassad Oussaief, a Ali Fendri, b Béatrice Chane-Woon-Ming, b Remy Poirey, c Henri-Jacques ... See full document

... The Epstein-Barr virus (EBV)-encoded LMP1 protein is an important component of the process of trans- formation by ...gene expression and its contribution to the development of ... See full document

... EGFR expression in MEF cells and the induction is completely abrogated in the absence of functional ...EGFR expression through another “atypical” NF-κB signaling event which is NIK- ...EGFR ... See full document

... Center, 1 Department of Microbiology and Immunology, 2 and Department of Medicine, 3 University of North Carolina, Chapel Hill, North Carolina 27599 Received 14 April 2003/Accepted 5 June 2003 We have shown ... See full document

... MMP-9 expression construct with a ...LMP 1-187 did not transactivate the MMP-9 ...LMP 1-231 and LMP del 187-351 had reduced transactivation, with LMP 1-231 and LMP del 187-351 retaining 50 and ... See full document

... various tumor virus gene products to bind and inactivate p53, thereby blocking its function in mediating growth arrest or apoptosis, has defined a role for both p53 and viral oncogenes in the ... See full document

... 2004 Latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is a transforming protein that affects multiple cell signaling pathways and contributes to ... See full document

... DISCUSSION EBV can deregulate B-cell growth through activation of endogenous programs of cellular gene expression. At the same time, these deregulated cellular genes can modulate the pro- gram of viral gene ... See full document

... the latent membrane protein 1 (LMP1) of EBV [ 28 ...only 1–2% of the tumour mass [ 29 ...LMP1 expression leads to activation of several signalling pathways, including epidermal ... See full document

... of protein expression detected by Western ...lyLMP-1 expression plasmids transfected or cotransfected for each experiment are shown below each bar of the ... See full document

... The latent membrane protein 1 (LMP-1) of Epstein-Barr virus (EBV) functionally resembles a constitutively active, CD40-like receptor and contributes to the ... See full document

... and tumor necrosis factor receptor-associated factor 1 (TRAF-1) protein ...(20) expression, demonstrating approximately 70% sort purity for transfected cells and more than 95% ... See full document

... Infection of Epstein-Barr virus-negative human B-lymphoma cell lines with the fully transforming B95.8 Epstein-Barr virus strain was associated with complete virus latent gene expression[r] ... See full document

... 2006 Epstein-Barr virus (EBV) infection is associated with the development of many B-cell lymphomas, including Burkitt’s lymphoma, Hodgkin’s lymphoma, and posttransplant lymphoproliferative ...The ... See full document

... with Epstein-Barr virus infection. The p53 tumour suppressor protein is rarely mutated in NPC suggesting that the inactivation of p53 pathway in NPC could be due to the ... See full document

... infectious virus provides gene expression levels that are physiologically relevant, one caveat should be raised pertaining to our use of the B95-8 recombinant EBfaV-GFP in these ...second virus ... See full document

... The expression of LMP at high levels in lymphoid cells is cytotoxic and correlates with an increased expression of Bcl-2 following stable selection for the introduced LMP gene; 2 days af[r] ... See full document

... signaling protein is that it is consistently expressed and detected in NPC tumors (10, ...LMP1 expression or a mechanism(s) may favor EBV persistence and latency early in NPC ...LMP1 expression ... See full document

... Statistical analysis A chi-square test, Fisher’s exact test or Kruskal Wallis test was used for statistical analysis of the IHC results and clinicopathologic findings. And the expression of mRNA or proteins was ... See full document