In the previous subsection, we provided one type of independent confirmation for the theory of verb raising proposed in section 1. The Verb Position Diagnostic (7) predicted that English, Mainland Scandinavian, and Faroese 2 have simple, unsplit IP structures, while Icelandic and Faroese I have split IPs. One characteristic of split IP languages should be the presence of specifier positions which are not found in languages with a simple IP (namely, the specifiers of the Agr-Phrases). Evidence from the distribution of arguments thus bore out the predictions based on (7). A second characteristic of split IP languages is that they should have more heads in the IP complex than languages with simple IPs. Independent evidence for these heads will be further support for the SIP, and thus for the proposals in section 2 of this paper. Such evidence comes from the domain of inflectional morphology. For more than a decade, it has been recognized that there is a connection between verbal morphology and overt verb raising (in non-V2 environments) in the Scandinavian languages (see e.g., Vikner 1995a,b, Rohrbacher 1994, Holmberg & Platzack 1995). The most common approach has been to suggest that sufficiently ‘‘rich’’ agreement morphology will force verb raising. However, the appropriate definition of ‘‘rich’’ has been notoriously difficult to discover. An alternative is proposed in Bobaljik (to appear) and developed in Bobaljik & Jonas (1996), Thra´insson (1996), and elsewhere. On this approach, it is not the ‘‘richness’’ of agreement morphology that is important, but rather the more general structure of the verbal morphology. In particular, it is the (im)possibility of multiple inflectional morphemes on the finite verb that is important, and not the features that these morphemes express.
This is a quote by the world renowned experts David W. Johnson and his brother Roger T. Johnson. Cooperative Learning is a part of a group of teaching/ learning techniques where students interact with each other to acquire and practice the elements of a subject matter and to meet common learning goals. It is much more than just putting students into groups and hoping for the best. Cooperative Learning is a very formal way of structuring activities in a learning environment that includes specific elements intended to
The other classroom teacher who served with a professional SLMS reported that the lack of time to talk with her SLMS prevented her from engaging in classroom–library collaboration. She pointed to a general lack of planning time in the elementary school day and to the fixed library schedule as barriers to collaboration. The two respondents who served with paraprofessionals noted that these people were not qualified “to teach curriculum” and that the “lack of resources” didn’t make the library particularly useful. One wrote, “No one (classroom teacher) that I have worked with has ever worked [collaborated] with a school library media specialist. They are shocked that such a thing exists! There seems to be no importance placed on the library and its staff and their possible role in students’ reading and learning. What a huge loss.” Along with the charter school classroom teachers who did not have the benefit of school libraries or SLMSs, these respondents’ answers pointed to woefully inadequate state- and district-level school library staffing policies and did not shed light on the practice of classroom–library collaboration.
95. The Durbin Effect: Two Years Later, Consumers Still Not Benefitting from Durbin Amendment, E LEC . P AYMENTS C OAL ., http://wheresmydebitdiscount.com/the-durbin-effect/ (last visited Apr. 6, 2014). This article, however, cites a survey that looks at low-cost items, such as milk, peanut butter, a hammer, and a Slurpee, to illustrate that the cost savings have not been passed along. This is flawed logic because low-priced items have a higher burden with the post-Durbin Amendment interchange fees than they did before the Durbin Amendment. 96. Vicki Needham, Retailers File Appeal Over Credit Card Swipe Fee Settlement, T HE
During the post-election violence in Kenya, there are two young men who were reported by BBC to have made a significant difference in the third largest slum in Africa, Kibera. Osodo belonged to the ethnic group that was in the opposition and Kyalo belonged to an ethnic group that was viewed to support the government. Osodo was expected by his own people to join the mobs that were causing havoc and death but he stayed inside his house. At one point, Osodo could not stand to hear and see people die so he stepped out to do something. The angry mob caught up with him and showered him several threats, accusing him to be a traitor. He ignored them and walked across to his friend’s house (Kyalo). These two decided to go out convene a meeting of the community to talk about peace. Before Koffi Annan, former United Nation’s General Secretary, announced peace for the nation, Osodo and Kyalo had brokered peace for the dwellers in Kibera.
simulations is a good estimator of GY for several crops (Palosuo et al., 2011, Rötter et al., 2012, Bassu et al., 2014) and possibly even betterthan the best individual model across different seasons and sites (Rötter et al., 2012). However, a detailed quantitative analysis of the quality of simulators based on crop model ensembles, compared to individual models is lacking. By looking at outputs of multiple growth variables (both in-season and end-of- season), we would get a broader picture of how ensemble estimators perform and a better understanding of why they perform well compared to individual models. It is important therefore to consider not only GY but also other growth variables. If multimodel ensembles are truly more skillful than the best model in the ensemble, or even simply betterthan the average of the models, then using ensemble medians or means may be a powerful estimator to evaluating crop response to crop management and environmental factors.
Deriving functional requirements from the use case always takes place on the journey from ideas to executable software. The question is simply a matter of who you want to have doing that derivation and when. (See Chapter 13, “How Much Detail Do You Need?”) If you deliver only use cases without all the functional detail to developers, each developer must derive the additional functionality on his own. A developer with little requirements analysis expertise might overlook some of these requirements. It’s also unlikely that all developers will record the functional requirements they identify. This makes it hard for testers to know exactly what they need to test. It also increases the chance that someone will inadvertently fail to imple- ment certain necessary functionality. If you’re outsourcing construction of the software, you can’t expect the vendor’s developers to accurately determine the unstated functionality from a use case description.
This study explored combinational anticancer therapy using α-helical peptides HPRP-A1/HPRP-A2 with the chemical drugs doxorubicin (DOX) and epirubicin (EPI). The in vitro activity of these drugs against different cancer cell lines was synergistically increased, as was their activity in a HeLa xenograft model in BALB/c nude mice. We delineated the mechanism of this synergy by studying the apoptosis pathway and morphologic changes in the HeLa cell membrane. The mechanism of the HPRP-A1/DOX combination was found to involve enhanced apoptosis, which seemed to be caspase-dependent and involved both the extrinsic and intrinsic parts of the caspase cascade in HeLa cells. Combined application of HPRP-A1 and DOX at low concentrations was significantly more effective than either drug alone against HeLa tumors in the mouse xenograft model. This type of combination therapy appears to have great clinical potential.
The BPV-1 E7 oncogene is a zinc binding protein 127 aminoacids long. E7 does not show a strong independent transforming activity, but when it is coexpressed with E5, its transformation capacity is pronouncedly increased . Mutants lacking the E7 open reading frame are still able to induce transformation but with lower efficiency . It is not clear how BPV-1 E7 contributes to cell transform- ation as this oncoprotein, in contrast to HPV-E7, lacks the LXCXE motif that mediates the binding to the pRB family proteins . It has been reported that the transformation activity of BPV-1 E7 is mediated, at least in part, by its ability to bind p600. The binding between BPV-1 E7 and p600 contributes to cell transformation by inhibiting the anoikis, a type of apoptosis, which is commonly encoun- tered in cancer cells, allowing them to survive in the ab- sence of normal cell-matrix interactions . In addition, BPV-1 E7 seems to sensitize the cells to TNF-induced apoptosis [23,24]. On the contrary E7 is the major trans- forming protein of BPV-4 as defined in in vitro systems [25,26]. BPV-4 E7 contains two Cys-X-X-Cys motif and the pRb-binding domain, both are critical for its trans- forming activity .
To test the developers on personality, data has been collected on parameters like program clarity, presentation; confidence level and satisfaction level 20 pairs for each category has been taken and to see the impact of pairs on personality and quality of a program. Data has been collected for parameters number of lines checked, tested methods, executed cases and execuTable lines as parameters. For these parameters data has been collected from 40 programs corresponding to solo intelligent, solo average, solo poor and compared it with pair of II, AA and PP by using a technique of pair-t-test to test the hypothesis.
participants were seated at the computer—one of them sitting in front of it and the other next to it—and were explicitly instructed to work together, in these words: “Even though only one of you can actually control the mouse, you have to perform the tasks as a team by consulting each other and making joint decisions. I also want you to state aloud what you are doing.” They were also told not to turn to the evaluator for assistance. The participants in both conditions then engaged in a brief TA practice session using the simple and neutral task of looking up the word “chant” in an online dictionary. On completion of this step, the participants then began the experiment proper. During the testing sessions, the evaluator remained in the same room as the participants and only issued think-aloud reminders if the participants fell silent for 15 seconds. In order to control for variation in computer performance, a single laptop connected to the University’s network was used for all experiments. The Morae software (2015) was used to record the computer screens and participants’ voices. Once the participants had completed the tasks, each participant was asked to fill in two online post-test questionnaires to provide feedback on the evaluated website (the System Usability Scale questionnaire) and the testing experience (Experience with TA Test questionnaire). Finally, the evaluator thanked the participants for taking part and gave each one of them the promised £5 as a token of appreciation for participating in the study.
Disentangling the relative impacts of duration (one year or two), dosage (number of hours per week), and quality (specific elements of structure and process quality) is a significant research challenge. These factors must also be understood in relation to the impact of broader influences, such as family engagement in learning, socio-economic conditions, and the quality of schools that children later attend, all of which independently impact children’s developmental outcomes. As such, the evidence base does not yet provide exact answers to all of the key issues relevant to policy-makers (see Appendix C for a discussion of the state of the evidence base). However, this report considers the collective weight of the evidence to draw conclusions about specific policy parameters important for the design of preschool programs.
The theory of hyperbolic discounting has very fruitfully been applied to savings decisions. Laibson (1997) shows that present-biased preferences can explain why con- sumption tracks income more tightly than predicted by the standard life-cycle model of savings, especially in the absence of commitment devices. O’Donoghue and Rabin (1999c) apply hyperbolic discounting to retirement planning. In the U.S. many em- ployees are eligible for a so called 401(k) retirement savings plan. Participation rates in these savings plans are relatively low, which is surprising because they are subsidized by the government and sometimes by the employer as well. Even though present-biased agents will want to eventually participate (in the long run people are patient), there is always something that hinders them to join because it promises a greater immedi- ate reward (in the short run people are impatient). Consequently, these agents may procrastinate indefinitely. O’Donoghue and Rabin’s theory is well supported by re- cent evidence. Madrian and Shea (2001) find that automatic enrollment of employees in 401(k) plans (employees must choose to opt out of rather than opt into the plan) exerts a strong influence over their saving choices.
The financial commitment may again be significant if complications arise. We will work with you to achieve consistent regulation, but some cats are difficult to keep regulated. It is important that you pay close attention to our instructions related to administration of medication, to diet, and to home monitoring. Consistency is the key to prolonged regulation. The more you keep the medication, diet, and activity the same from one day to the next, the easier it will be to keep your cat regulated. Another complication that can arise is hypoglycemia or low blood sugar; if severe, it may be fatal. This may occur due to inconsistencies in treatment or because some cats can have a spontaneous remission of their disease. This will be explained in subsequent paragraphs.
The algorithm as described in Section 4.1 is aggressive in nature because it aims to turn off as many interfaces as possible in an insistent manner. It fails to find a solution when the traffic load on the network is high. The algorithm described below is less aggressive and it is expected that it will give us a successful routing even under high traffic load conditions. As in Section 4.1.1, K is an incrementally built graph data structure that represents the network that consists of only those interfaces that are switched “on” by the algorithm in order to satisfy the given traffic demand. To start with, K consists of only vertices (or nodes) and no edges (or links). The interface-pairs are ordered in increasing order of their cost. The traffic elements are ordered in decreasing order of their magnitude and the traffic components are attempted to be routed in the same decreasing order. The interface-pairs are switched on one-by-one in increasing order of their cost. As explained in Section 3.2 the cost of each interface pair is the power consumed when the interface-pair are switched on. Each traffic element is attempted to be routed over the shortest Dijkstra path in K. Again, as mentioned in Section 4.1, the shortest path is the least cost path. If no path is found, then the next cheapest pair of interfaces in the ordered list is switched on and K is updated. The traffic element is attempted to be routed over the shortest path P in K until either a path is found in K or all the interface-pairs in the network have been switched “on”. Bifurcated routing of traffic is allowed and hence integral sub-components of traffic may be routed over different paths .If there is a tie in the Dijkstra shortest path (least cost path), then the ties are broken randomly. When all the traffic elements have been successfully routed, the interface-pairs that were switched on, but have no traffic flowing over them are switched off.
composition had evolved, and the finished work did not seem as labored as the earlier pieces of a similar fashion. Thus, I abandoned the fragments and embraced a return to painting and drawing on paper. These new works continued the imagery developed with the fragments, i.e., mixing drawn ink lines with painted shapes. I enjoyed the negative space around the fragment (drawn in pencil) more than mounted paper on shaped wood. I also began titling the maps with a series of random letter and number combinations (often chosen purely by the aesthetic of their combinations). For example, Map 98ww89 is a palindrome.
One of the major credit card companies has a popular feature called “Sign and Travel.” That’s a fair description of aspiring-principal internship programs in too many preparation programs today. These programs go through the motions of mentoring, requiring that a practicing principal grant a “professional seal of approval” before a new principal is certified. In reality, this professional approval process amounts to little more than the practitioner’s willingness to affix his or her signature to the requisite forms of internship completion. Just sign and travel. It’s no trouble for anyone — unless you consider the thousands of underperforming schools in our region that desperately need highly capable new principals.