[PDF] Top 20 Update on imatinib for gastrointestinal stromal tumors: duration of treatment

... of treatment or a complete radiological ...of imatinib were also more likely to have a short progression-free survival upon imatinib rechallenge, which probably reflects the biological ... See full document

... whose tumors were not growing at the time of surgery, limited disease progression or generalized disease progression) and surgical result (no evidence of disease, minimal residual disease or bulky residual ... See full document

... of imatinib is a milestone in the treatment for locally advanced and metastatic gastrointestinal stromal tumor (GIST) at a dose of 400 ...of imatinib plasma levels are presently ... See full document

... of treatment with ...and treatment-specific data were extracted from sarcoma databases, medical records and patient charts at each in- ...therapy, duration and dose of systemic therapy, complications ... See full document

... extended duration of adjuvant treatment will bring patients more economical burdens and drug ...prolonged- duration of adjuvant imatinib ...the duration of their adjuvant ... See full document

... IM treatment for a median length of ...IM duration, the tumor tended to shrink greatly, but still the tumor shrinkage occurred predominantly within 6 to 12 months, slight tumor shrinkage could be observed ... See full document

... of gastrointestinal sar- coma ...[22,23]. Tumors with more than 10% of nuclei positive for Ki-67 analogs developed metastases more easily and had higher tumor-related mortality ...bowel ... See full document

... TKI imatinib and sunitinib proved ineffective or only partially effective, respectively, in SDH-deficient GISTs, coherently with SHD deficiency constituting a pathway independent of ...these tumors, TKI ... See full document

... year imatinib therapy? The real benefits and optimal time to stop treatment still need further study and it still remains the possibility of recurrence after stopping taking the ...Neoadjuvant ... See full document

... Understanding genetic signatures and complex signaling networks are crucial for yielding successful outcomes using targeted therapies. Since regorafenib targets multiple kinases, further investigation of the interplay ... See full document

... Gastrointestinal stromal tumors have been a diagnostic dilemma to the medical science in the past decades because of the clinical presentation and improper ...These tumors generally arise in ... See full document

... developed imatinib resistance were documented 12 cases with exon 17 mutations (including also N822K mutations), and all the patients with these secondary mutations failed to benefit from switching treatment ... See full document

... optimal duration of adjuvant TKI therapy remains debatable, patients with GLM seem to have to maintain the treatment ...with imatinib for GIST patients with resectable hepatic lesions and found that ... See full document

... Abstract: Gastrointestinal stromal tumors (GISTs) are relatively rare neoplasms of the gastro- intestinal tract originating from the pluripotential mesenchymal stem cells, which differentiate into ... See full document

... and treatment of potentially curable disease recurrences, 2) recognition of therapy-related complications, and 3) de- tection of symptoms consistent with metastatic ...with treatment initiation leads to ... See full document

... the treatment of choice for patients with localized ...For tumors that lack these features, endoscopic surveillance is an ...with imatinib may be preferred if a tumor is borderline re- sectable, or ... See full document

... Surgical resection of the tumor is the current priority management for localized GISTs [9]. Owing to GISTs have a risk of tumor rupture dur- ing operation which may lead to the spread of tumor cells, en bloc resection of ... See full document

... and imatinib alone or combina- tion on imatinib-resistant GIST cell lines, and to explore the possible ...mechanism. Imatinib resistant GIST cell lines (GIST-R) were exposured to either Peg-IFNα-2b ... See full document

... Several approaches exist for resection of rectal GIST, but the principle of surgery is complete resection with an intact pseudo-capsule [10, 11]. Local resection, such as transanal, trans-sacral, or transvaginal, may be ... See full document

... after treatment, even if the size increases, the treatment should be considered effective, thus improving the accuracy and sensitivity ...preoperative treatment, and the difference was statistically ... See full document