[PDF] Top 20 Update on the treatment of gastrointestinal stromal tumors (GISTs): role of imatinib

... A wide range of newer and more potent small molecule TKI that target KIT and/or PDGRA are in development. An agent with interesting single agent activity is sorafenib. Sorafenib is a multi-targeted small molecule TKI ... See full document

... Abstract: Gastrointestinal stromal tumors (GISTs) are the most common sarcoma of the gastrointestinal tract, with transformation typically driven by activating mutations of c-KIT and ... See full document

... Abstract: Gastrointestinal stromal tumors (GISTs), the most common sarcoma of the GI tract, have unique kinase mutations that serve as targets for medical ...(TKI) imatinib in GIST ... See full document

... malignant tumors of the gastrointestinal tract that have been thoroughly studied over the past few ...standard treatment for non-metastatic GISTs, progress has been made in the development of ... See full document

... without imatinib adjuvant therapy and met the criteria in our study, were divided into two cohorts by different surgical time periods for getting more reli- able results as a single center ...of GISTs (male ... See full document

... developed imatinib resistance were documented 12 cases with exon 17 mutations (including also N822K mutations), and all the patients with these secondary mutations failed to benefit from switching treatment ... See full document

... unresectable GISTs. Postoperative imatinib treatment is recommended if the tumor is removed grossly, but the operative specimen has positive microscopic margins, designated as R1 resection, or if a ... See full document

... with imatinib for unresectable/potentially resectable gaster and duodenum gastrointestinal stromal tumor ...received imatinib as preoperative therapy at the Affiliated Hospital of Inner ... See full document

... Among the 100 patients, 86 underwent segmental resec- tion of the small intestine with the tumor and the involved mesentery, peritoneum, retroperitoneum, or other contiguous intra-abdominal organs. Six patients with a ... See full document

... Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal ...molecular treatment of cancer. GISTs are characterized by the presence of ... See full document

... Gastrointestinal stromal tumors have been a diagnostic dilemma to the medical science in the past decades because of the clinical presentation and improper ...These tumors generally arise in ... See full document

... risk GISTs thereby necessitating lifelong surveil- ...and treatment of potentially curable disease recurrences, 2) recognition of therapy-related complications, and 3) de- tection of symptoms consistent ... See full document

... in gastrointestinal stromal tumors (GISTs) and melanoma tumors (including mucosal, acral, and those arising from chronically sun damaged ...GIST tumors express the c-KIT receptor ... See full document

... of GISTs have activating mutations in tyro- sine kinase receptor (KIT) and platelet-derived growth factor receptor alpha (PDFRA) genes, which are respon- sible for tumor development ...[8,9]. Imatinib, a ... See full document

... with GISTs or digestive tract malignancies underwent surgical treatment with curative ...tract tumors. The risk stratification of GISTs was evaluated according to the modified National ... See full document

... of GISTs and is frequently mutated, leading to constitutive activation in these ...and Treatment of Cancer (EoRTC) phase I study2 identified the highest feasible dose of Imatinib to be 400 mg bid and ... See full document

... curative treatment in which the resected specimen should have negative margins and integrity of the pseudocapsule ...Laparoscopic treatment of GIST can be performed taking strict oncological precaution to ... See full document

... Understanding genetic signatures and complex signaling networks are crucial for yielding successful outcomes using targeted therapies. Since regorafenib targets multiple kinases, further investigation of the interplay ... See full document

... of GISTs was evaluated according to the modified National Institutes of Health classification ...the tumors was classified into three categories, as follows: R0 (complete gross and microscopic resection), ... See full document

... term gastrointestinal neuro- fibromatosis has been applied to a group of clinicopathologically and genetically heteroge- neous group of conditions, some of them could be well characterized in recent ...KIT ... See full document