[PDF] Top 20 Urinary soluble urokinase receptor levels are elevated and pathogenic in patients with primary focal segmental glomerulosclerosis

... the pathogenic do- main or part of the suPAR molecule in FSGS is not fully elucidated; it might be a specific domain, or a special form of glycosylation or phosphorylation of this interesting ...of primary ... See full document

... and primary FSGS. Elevated serum VEGF levels are one of the major criteria for the diagnosis of POEMS syndrome ...main receptor for ...be elevated in patients treated with ... See full document

... The primary structure of the ma- ture uPAR is formed by approximately 90-amino-acid, cysteine-rich LY6-like, short linker regions connecting three homologous domains (D1, D2, and D3, numbered from the N-terminus) ... See full document

... from patients with recurrent disease after ...from patients with recurrent FSGS after plasma- pheresis as well as the plasmapheresis fluid that was gained from these ...is soluble ... See full document

... Demographic and clinical data included age at diagno- sis, gender, comorbidities, height, weight, body mass index (BMI), blood pressure, presence of nephrotic syn- drome, serum creatinine, estimated glomerular filtration ... See full document

... An ultrasound-guided kidney biopsy was performed; the final pathologic diagnosis was FSGS. Among 16 glomeruli, seven showed global sclerosis and two showed segmental glomerulosclerosis (Fig. 1a). Mild ... See full document

... is segmental or global wrinkling and collapse of capillary walls and overlying epithelial cell proliferation ...from focal segmental glomerulosclerosis as the lesions are charac- terized by ... See full document

... of patients with either MCD or idiopathic FSGS treated with the ACTH analog Acthar ...these patients, and there was no set protocol for treatment. All patients received prior renin–angiotensin system ... See full document

... potassium diet in 9patients (5.7%). Diuretics were used in 141 patients (91.5%). Furosemide is used alone in 133 patients (85.2%) and associated to aldosterone blocker in 15 patients (9.6%) and to ... See full document

... that levels of microRNA are dysregulated in NS patients with different histopathology; however, the data are not ...miRNA levels in different reports, including patients’ related factors (age, ... See full document

... LN patients, which lacked taurine altogether (Table 2) (P score = ...at levels in the range from 50 to 750 μM ...IV patients indicated a renal pathology that was distinct from class V patients ... See full document

... The glomerulus is primarily composed of three cell types, the podocytes, mesangial cells and endothelial cells. While the podocyte is often the primary site of injury, subsequent changes in all three cell types ... See full document

... suPAR levels in patients with rFSGS or other kid- ney disease deserve more attention, especially because experimental evidence is emerging that suggests inhibit- ing uPAR pathway by cyclo-RGDfv, uPAR ... See full document

... Focal segmental glomerulosclerosis (FSGS) is the second most common cause of idiopathic nephrotic syndrome in childhood and often progresses to renal insufficiency.’ Although FSGS has be[r] ... See full document

... in patients with sepsis ...identify patients with an extraordinarily high mortality risk (and who thus deserve aggressive management) but also provide potential therapeutic ... See full document

... Lee’s grade was divided into grade I, II, III, IV, V according to Lee’s glomerular grading sys- tem [4]. Oxford classification was scored as follows: mesangial score ≤0.5 (M0) or >0.5 (M1), endocapillary ... See full document

... Focal segmental glomerulosclerosis (FSGS) was first rec- ognized in the 20 th century as a histopathological pattern of glomerular injury associated with nephrotic syndrome (NS) ...of patients ... See full document

... in patients with ...two patients similar to ours with FSGS in the ipsilateral kidney following revascularization of a single functioning kidney [11, ...These patients developed nephrotic-range ... See full document

... years, focal segmental glomerulosclerosis (FSGS) is currently a common cause of nephrotic syndrome and re- sponsible for 15% end-stage renal disease ...FSGS patients require kidney ... See full document

... is focal segmental glomerulosclerosis with collapse of the glomerular tuft, associated with dilated tubules with ...of patients, has become a rare finding, possibly owing to more effective ... See full document