[PDF] Top 20 Use of clofarabine for acute childhood leukemia
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Use of clofarabine for acute childhood leukemia
... up to 11 cycles (median two). The median time between two cycles was 28 (range 12–55) days. The results of this trial showed an OR rate of 20% (seven CR and five CRp), and an additional PR rate of 10%. CR patients who ... See full document
8
WILMS' TUMOR GENE 1 (WT1) EXPRESSION IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA
... expressionin childhood ALL is very variable and, in general, much lower than in AML or adult ...in childhood ALL. But like in other types of acute leukemia, also, childhood ALL patients ... See full document
5
Health-related quality of life in long-term survivors of relapsed childhood acute lymphoblastic leukemia.
... Survivors had lower SF-36 means for physical function, role physical, role emotional, and vitality than the norm population, but they were still well within one standard deviation of the norm. In a study by Reulen and ... See full document
8
Childhood B-acute lymphoblastic leukemia: a genetic update
... in epigenetic regulators (discussed more below) [97]. Epigenetic studies have also shown insights into our understanding of MLL-rearranged B-ALL. MicroRNAs (miRNAs), short noncoding RNAs involved in the regulation of ... See full document
14
Socioeconomic Status and Other Characteristics in Childhood Leukemia
... of acute lymphoblastic leukemia aged 1 to14 years in Department of Pediatric Oncology of ...between childhood Acute Lymphoblastic Leukemia and parental education, income status, ... See full document
5
A Bayesian multivariate latent t-regression model for assessing the association between corticosteroid and cranial radiation exposures and cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia: a PETALE study
... the use of the R function pmvt which evaluated the latent variables’ multivariate Student-t cumulative distribution function was found to be a bottle- neck for the computation of the cumulative population risk ... See full document
11
Obesity in patients with acute lymphoblastic leukemia in childhood
... Of the drugs used to treat ALL, glucocorticosteroids are the only one with a known effect on weight gain. Corticosteroids can promote obesity via a range of pos- sible mechanisms: effects on appetite/regulation of energy ... See full document
11
Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia
... of acute myeloid leuke- mia (AML) and has provided important insights into the biology of this disease (10, ...in childhood ALL have exam- ined cytosine methylation of the promoters of individual genes, ... See full document
14
Association between Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphisms and Susceptibility to Childhood Acute Lymphoblastic Leukemia in an Iranian Population
... Atashrazm et al. 35 investigated the impact of MTHFR C677T and A1298C polymorphisms and the risk of ALL in patients referred to the Iranian Blood Transfusion Organization (Tehran, Iran). In agreement with our finding, ... See full document
8
Evaluating the Role of Birth Weight and Gestational Age on Acute Lymphoblastic Leukemia Risk Among Those of Hispanic Ethnicity.
... childhood cancer or plausibly associated with BW, GA, or childhood cancer. The variables abstracted and used in the analyses included: infant gender, race/ethnicity (recorded as the race of the mother on ... See full document
18
Chromosomal Aberrations in ETV6/RUNX1-positive Childhood Acute Lymphoblastic Leukemia using 244K Oligonucleotide Array Comparative Genomic Hybridization
... Various techniques to screen and study chromosomal aberrations in ALL have been developed in recent years. Conventional cytogenetics is routinely used in the initial assessment for the purpose of classification of ... See full document
6
Clinical use of blinatumomab for B-cell acute lymphoblastic leukemia in adults
... lymphoblastic leukemia (ALL) is an aggressive hematologic malignancy characterized by highly proliferative immature lymphoid cells in the bone marrow and peripheral ... See full document
10
The Role of Chromosomal Aberration in Childhood Leukemia
... Environmental factors are including: Physical agents such as radiations, Chemical agents such as benzene and antineoplastic drugs, viral agents such as Epstine barr virus, HTLVI and influenza infection [7,11,28,34,42]. ... See full document
7
Volume 3, Issue 4, April 2014 Page 129
... of leukemia [8]. In conventional leukemia screening process, Hematologists will look for the large number of abnormal white blood cells on stained ...the leukemia as either ALL or ... See full document
5
Face Bones Involvement and Relapse in a Case of Childhood Acute Leukemia
... Childhood acute lymphoblastic leukemia (ALL) is the most common type of cancer in ...of childhood ALL and predicting the patient’s ...in childhood ALL 1 ... See full document
5
Leukemia relapse following unmanipulated haploidentical transplantation: a risk factor analysis on behalf of the ALWP of the EBMT
... Allogeneic stem cell transplantation (allo-SCT) repre- sents a curative option for intermediate- and high-risk adult acute leukemias (AL). In the absence of a matched donor, haploidentical donors are increasingly ... See full document
11
Current Indications of Bone Marrow Transplantation (BMT) in Pediatric Malignant Conditions a Review
... Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) was previously consid- ered as an absolute indication for HSCT including matched unrelated donor (MUD). With the introduction of imatinib and ... See full document
5
Genetic Aberrations In Childhood Acute Lymphoblastic Leukaemia (All): Application Of High-Density Single Nucleotide Polymorphism Array (SNPA)
... in childhood ALL. Frequent occurrences of AID in childhood ALL may implicate this event as contributing to the presence of allelic imbalance, but the mechanisms involved in this pathogenesis remain ... See full document
8
COMPARISON OF DAILY AND TWICE-WEEKLY SCHEDULE OF L-ASPARAGINASE IN CHILDHOOD LEUKEMIA
... : Comparison of daily versus weekly L-asparaginase for the treat- ment of childhood acute leukemia. : The clinical toxicities of L-as-[r] ... See full document
8
A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia
... low-dosage clofarabine and that the combination displayed some encouraging clinical activity ...[14]. Clofarabine is a a second-generation purine nucleoside analogue which has been synthesized to overcome ... See full document
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