[PDF] Top 20 Ventral embryonic tissues and Hedgehog proteins induce early AGM hematopoietic stem cell development

... adjacent tissues (Rossant and Tam, 2004; Tam and Zhou, 1996). The hematopoietic system, although not generally thought of as a tissue that undergoes patterning, does develop in several distinct anatomical ... See full document

... of hematopoietic development during embryo- genesis in vivo are important to gain insight into its underlying mechanisms, whereby accumulated know- ledge will facilitate the induction of HSCs, ... See full document

... the AGM and possibly yolk sac, 3) expansion of HSCs in the placental vascular labyrinth and 4) functional matu- ration of functionally immature “pre-HSCs” into HSCs that can engraft in standard transplantation ... See full document

... In this sense, the talk of Arnold Kriegstein (University of California, San Francisco, USA) should have a particular impact for organoid research. He utilized human fetal brain tissue for live imaging, lineage tracing, ... See full document

... to induce ectopic tail formation, and visualized tbx6 promoter-driven GFP during late somitogenesis ...the ventral region of the embryo ...various cell types from the primary tail, these data show ... See full document

... cell stripe depends on the En cells. As Hh is secreted by En cells (Tabata and Kornberg, 1994; Taylor et al., 1993), and is required for groove formation (Larsen et al., 2003), we investigated whether it controls ... See full document

... by early researchers was only one aspect of mouse variation. Early breeding experiments lead to the production of inbred mouse strains, many of which serve as useful models for various human conditions and ... See full document

... glial cell- line derived neurotrophic factor (AdGDNF) one week prior to cortical contusion injury in rats resulted in neu- roprotection but not functional recovery ...for proteins known to be initiated ... See full document

... the number of cells as shown in Table III. The relative proportions of blood in fetus and placenta were determined from total iron values on the same material since non- hemoglobin iron [r] ... See full document

... essential regulators of hematopoietic stem cell development downstream of Notch signaling. Notch1 inhibits 567[r] ... See full document

... to hematopoietic development, undertaken at the end of the XIXth century, was based on the observation of embryos at various development ...the development of clusters of red cells. A careful ... See full document

... In mutant embryos the scutellum ceases growth and development early in kernel development, while tissues surrounding the embryonic axis continue to grow and divide, and ev[r] ... See full document

... dental development, as Sp3 -/- mice lacked the dentin and enamel layers of the teeth, and Sp3 is found at the promoters of genes involved in specifying dental progenitors (Bouwman et ...the cell cycle, ... See full document

... HH: Hedgehog; HHIP: Hedgehog-interacting protein; HSC: Hematopoietic stem cell; HSPCs: Hematopoietic stem and progenitor cells; IHH: Indian Hedgehog; ITD: Internal ... See full document

... chain proteins MLC2A and MLC2V can be used to distinguish between atrial and ventricular cardiomyocytes in mice, and MLC2V has been used to genetically select for ventricular myocytes using a lentivirus-transduced ... See full document

... (Lineage Cell Depletion kit, Miltenyi Biotec), magnetic labeling of retrieved total nucleated cells was performed, and the lineage-negative (Lin − ) cells were isolated by depletion of mature hematopoietic ... See full document

... mammalian development beyond a descrip- tive effort was ...the embryonic and extraembryonic cell types in the mouse (Rossant and Papaioannou, 1977; Gardner, ...carcinoma stem cells (EC) (see ... See full document

... of hematopoietic development depend heavily on multifactorial transcrip- tional regulating protein complexes that can perform multiple functions depending on the context of their interactions, it is less ... See full document

... mutant cell line derived from Chinese hamster ovary (CHO) cells that lack the endog- enous expression of heparin sulfate proteoglycans (31) and was main- tained in Dulbecco’s modified Eagle’s medium (DMEM)–F-12 ... See full document

... cancer stem cells (CSCs), found in solid tumors, may contribute to metastatic processes such as migra- tion, resistance to current treatment modalities, includ- ing chemo- and radiation therapy, and resistance to ... See full document