[PDF] Top 20 JC Virus-Specific Cytotoxic T Lymphocytes in Individuals with Progressive Multifocal Leukoencephalopathy
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JC Virus-Specific Cytotoxic T Lymphocytes in Individuals with Progressive Multifocal Leukoencephalopathy
... the T and VP1 JCV genes were inserted into vaccinia virus (NYCBH strain A) at a nonessen- tial site in the HindIII M region by in vivo recombination ...vaccinia virus 40K transcriptional promoter was ... See full document
5
Progressive Multifocal Leukoencephalopathy Associated Mutations in the JC Polyomavirus Capsid Disrupt Lactoseries Tetrasaccharide c Binding
... of virus that resides in the kidney is referred to as the archetype strain (Cy) and can be de- tected in the urine of healthy individuals (4, ...the virus to the neuropathogenic form (34, 39, ... See full document
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Lymphocyte Gene Expression and JC Virus Noncoding Control Region Sequences Are Linked with the Risk of Progressive Multifocal Leukoencephalopathy
... PML is caused by JCV lytic replication in glial cells in the CNS. While many people are infected with JCV, PML is categorized as a rare disease (18). NCCRs detected in the urine of asymptomatic healthy individuals ... See full document
7
JC Virus Regulatory Region Tandem Repeats in Plasma and Central Nervous System Isolates Correlate with Poor Clinical Outcome in Patients with Progressive Multifocal Leukoencephalopathy
... most individuals regardless of their degree of immunosuppression (15, 21), we concentrated our efforts on DNA samples obtained from blood, CSF, and brain ... See full document
5
Improving detection of JC virus by ultrafiltration of cerebrospinal fluid before polymerase chain reaction for the diagnosis of progressive multifocal leukoencephalopathy
... particles with a diameter of 35–40 nm [5], it is likely that ultrafiltration of CSF specimens could be applied to PCR assays for other neurotropic viruses with larger virions, such as those of the family Herpesviridae. ... See full document
9
Cross-Reactivity of T Lymphocytes Recognizing a Human Cytotoxic T-Lymphocyte Epitope within BK and JC Virus VP1 Polypeptides
... BK virus (BKV) is a ubiquitous human polyomavirus that causes asymptomatic primary infection and establishes persis- tent infection in several body sites, notably the kidney ...immunocompromised ... See full document
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Adaptive Mutations in the JC Virus Protein Capsid Are Associated with Progressive Multifocal Leukoencephalopathy (PML)
... JC virus is a highly prevalent human polyomavirus. Infection with this virus is generally benign and asymp- tomatic despite viral persistence in the kidney of many ...immunocompromised ... See full document
8
JC Virus Quasispecies Analysis Reveals a Complex Viral Population Underlying Progressive Multifocal Leukoencephalopathy and Supports Viral Dissemination via the Hematogenous Route
... human JC polyomavirus may result in the development of progressive multifocal encephalopathy in immunocompromised ...Neurotropic JC virus generally harbors reorganized noncoding control ... See full document
8
<p>Progressive Multifocal Leukoencephalopathy: Current Insights</p>
... CD8-positive T-cells homeostasis. Plasma cells regulate in fl ammatory T-cells activity via the immuno- checkpoin pathways, thereby protecting the brain from excessive immune-mediated damage during active ... See full document
13
Progressive Multifocal Leukoencephalopathy—A Case Report in an Immunocompetent Patient
... in individuals with no co- morbidities and without known cause of immunosuppression, but we emphasize that in half of these cases the HIV serology was not ... See full document
7
Deep-Sequence Identification and Role in Virus Replication of a JC Virus Quasispecies in Patients with Progressive Multifocal Leukoencephalopathy
... DNA viruses, including JCV, generally have fewer mutations than RNA viruses. JCV isolates from PML patients have unique mutations, deletions, and/or rearrangements (so called PML-type rearrangements) in the regulatory ... See full document
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An animal model for progressive multifocal leukoencephalopathy
... increased during the AIDS pandemic, with the disease occurring in 2%–5% of HIV-infected individuals (17). In 2005, the first cases of PML appeared in patients that were being treated with humanized monoclonal ... See full document
5
Frequency and Phenotype of JC Virus-Specific CD8+ T Lymphocytes in the Peripheral Blood of Patients with Progressive Multifocal Leukoencephalopathy
... Asymptomatic JC viruria occurs in up to one-third of healthy individuals, while JC viremia is found mainly in immunosup- pressed individuals who are at risk of developing PML ...low JC ... See full document
9
JC Virus Latency in the Brain and Extraneural Organs of Patients with and without Progressive Multifocal Leukoencephalopathy
... healthy individuals and that rearrangements which confer neurotro- pism need to occur prior to viral migration to the brain to destroy the myelin-producing glial ...otherwise-healthy individuals are matters ... See full document
10
JC Virus-Specific Immune Responses in Human Immunodeficiency Virus Type 1 Patients with Progressive Multifocal Leukoencephalopathy
... (EIA), virus-like particles (VLP) were produced by expressing the JCV capsid protein 1 in insect cells from a recombinant baculovirus, and EIAs were performed as previously described (13, ...JCV-specific ... See full document
8
Role of CD4+ and CD8+ T-Cell Responses against JC Virus in the Outcome of Patients with Progressive Multifocal Leukoencephalopathy (PML) and PML with Immune Reconstitution Inflammatory Syndrome
... a virus in the blood and to monitor this response in vaccine ...by T-cells after recognition of their cognate ...cific T-cells, ICS makes the distinction between antigen-spe- cific CD4 ⫹ and CD8 ⫹ ... See full document
8
An Antigenic Threshold for Maintaining Human Immunodeficiency Virus Type 1-specific Cytotoxic T Lymphocytes
... Results: The LTNPs had high levels of HIV-1- specific memory CTLp and CTLe, while maintaining a low plasma viral load. Despite also having low viral loads, patients whose plasma viremia was well-sup- pressed by ... See full document
7
Virus-Specific Cytotoxic T Lymphocytes in Human Immunodeficiency Virus Type 1-Infected Chimpanzees
... B virus and HIV epitopes defined in infected humans were also recognized by CTL found in virus-infected ...These lymphocytes then were tested for lytic activity against autologous B-LCL pulsed with ... See full document
5
Specific cytotoxic T lymphocytes recognize the immediate-early transactivator Zta of Epstein-Barr virus.
... the virus are pre- sumed to express only EBNA 1 ...for specific CTL. Production and release of infectious virus by these cells could therefore be inhibited only by immune mechanisms directed against ... See full document
8
Lack of Viral Escape and Defective In Vivo Activation of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes in Rapidly Progressive Infection
... The results of this study demonstrate a strikingly static CTL response over the course of progressive infection. The initial detectable CTL response was directed against a single epitope and broadened to target a ... See full document
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