[PDF] Top 20 In vivo leukocyte tropism of bovine leukemia virus in sheep and cattle.
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In vivo leukocyte tropism of bovine leukemia virus in sheep and cattle.
... Nevertheless, BLV could be detected both in bovine CD5+ and CD5- B cells and in sheep CD11b+ and CDllb- B cells, indicating that the restricted BLV tropism for a specific B-cell subpopul[r] ... See full document
8
In vivo transcription of the bovine leukemia virus tax/rex region in normal and neoplastic lymphocytes of cattle and sheep.
... Southern blot analysis of amplified cDNA from freshly isolated tumor cells from a BLV-seronegative cow with thymic lymphosarcoma, a BLV-seropositive cow with EBL, and a BLVseropositive s[r] ... See full document
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Bovine Leukemia Virus-Induced Persistent Lymphocytosis in Cattle Does Not Correlate with Increased Ex Vivo Survival of B Lymphocytes
... of sheep PB- MCs in ex vivo cultures (9, ...the virus in the inhibition of the cellular apoptotic programs in sheep ...in cattle, we analyzed the apoptosis levels within the ... See full document
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Complete Bovine Leukemia Virus (BLV) Provirus Is Conserved in BLV-Infected Cattle throughout the Course of B-Cell Lymphosarcoma Development
... defective virus can escape cytotoxic T lympho- cytes, with a consequently greater likelihood of leukemic ...pro- virus, with the features expected for a genome that can gener- ate viral particles, was ... See full document
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Bovine Leukemia Virus-Induced Lymphocytosis and Increased Cell Survival Mainly Involve the CD11b+B-Lymphocyte Subset in Sheep
... Bovine leukemia virus (BLV), an oncogenic complex retro- virus, is homologous to human T-cell leukemia viruses (HTLV-1 and -2) and simian T-cell leukemia ...infected ... See full document
8
Role of the Proline-Rich Motif of Bovine Leukemia Virus Transmembrane Protein gp30 in Viral Load and Pathogenicity in Sheep
... of cattle with bovine leukemia virus (BLV), a member of the BLV-human T-cell leukemia virus (HTLV) group of retroviruses, results in persistent lifelong infection, the mechanism ... See full document
8
Inhibition of Histone Deacetylases Induces Bovine Leukemia Virus Expression In Vitro and In Vivo
... ex vivo-isolated peripheral blood mononuclear cells (PBMCs) from bovine leukemia virus (BLV)-infected ...from cattle, the natural host for ... See full document
9
Mapping of CD4+ T cell epitopes in bovine leukemia virus from five cattle with differential susceptibilities to bovine leukemia virus disease progression
... BLV contains the structural genes gag, pol, and env and the two regulatory genes tax and rex. The gag gene en- codes three mature proteins, i.e., p15 (matrix protein), p24 (an abundant capsid protein), and p12 ... See full document
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Early Syncytium Formation by Bovine Leukemia Virus
... In fact, when cell densities of 4 x 105 cells per 2.1 cm2 or greater are used, discrete syncytia are very difficult to observe even after 24 to 48 h Downloaded from http://jvi.asm.org/ o[r] ... See full document
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Viral determinants that control the neuropathogenicity of PVC-211 murine leukemia virus in vivo determine brain capillary endothelial cell tropism of the virus in vitro.
... Our results suggest that the 5' half of the SU gp70 coding region of the env gene of PVC-211 MuLV contains the determinants responsible for the induction of pathological changes in the C[r] ... See full document
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Suboptimal Enhancer Sequences Are Required for Efficient Bovine Leukemia Virus Propagation In Vivo: Implications for Viral Latency
... In the supershift experiments, 1 l of the appropriate antibody was added to the DNA-protein complexes and incubated for an additional 15 min at room temperature before the reaction mixtures were loaded onto the ... See full document
12
Epidemiology and genetic diversity of bovine leukemia virus
... Bovine leukemia virus (BLV), an oncogenic member of the Deltaretrovirus genus, is closely related to human T-cell leukemia virus (HTLV-I and ...infects cattle worldwide and ... See full document
16
Bovine leukemia virus discovered in human blood
... DNA was extracted from the blood buffy coat layer using the QIAamp® DNA mini kit (Qiagen, Valencia, CA, USA, catalogue #51304) according to manufacturer’s instruc- tion. The positive control cell line was FLK, a ... See full document
10
Pathogenicity of molecularly cloned bovine leukemia virus.
... _ Southern analysis of SstI digests of PBMC DNA from infected sheep yielded detectable signal only from cloneinfected sheep L4 and 41 at 38 and 53 months p.i., respectively, and sheep 5,[r] ... See full document
10
Identification of alternatively spliced mRNAs encoding potential new regulatory proteins in cattle infected with bovine leukemia virus.
... 67, 1993 ALTERNATIVELY SPLICED mRNAs OF BOVINE LEUKEMIA VIRUS In summary, the in vitro data indicated that the alternative spliced mRNAs, as described for the Tax/Rex mRNA 42, 76, 77, ca[r] ... See full document
14
Transcriptional activation of bovine leukemia virus in blood cells from experimentally infected, asymptomatic sheep with latent infections.
... We found that rare mononuclear cells rapidly isolated from peripheral blood contained a low amount of BLV RNA but that most infected cells did not contain detectable viral RNA.. Removal [r] ... See full document
9
Assessment of Bovine Leukemia Virus Transcripts In Vivo
... in vivo is limited, the results demonstrate the con- tinued presence of X region transcripts in significant numbers of ...Limited virus expression was also observed in NBC-13 cells, and these results ... See full document
8
Episodic occurrence of antibodies against the bovine leukemia virus Rex protein during the course of infection in sheep.
... The course of infection in these sheep has been characterized by several measures of viral gene expression and by their antibody responses to BLV structural proteins.. The events of very[r] ... See full document
7
Complete suppression of viral gene expression is associated with the onset and progression of lymphoid malignancy: observations in Bovine Leukemia Virus infected sheep
... of leukemia, were consistently positive ...naïve sheep injected with the cloned S2531 proviral DNA isolated from leukemic cells failed to seroconvert and BLV-specific PCR was con- sistently negative, ... See full document
9
Macrophage tropism determinants of human immunodeficiency virus type 1 in vivo.
... The V3 envelope domain was also found to be capable of conferring macrophage infection upon NLHX when derived from uncultured polymerase chain reaction clones from brain [NLHXw1-lclBgpj [r] ... See full document
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