[PDF] Top 20 Waldenström macroglobulinemia: biology, genetics, and therapy
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Waldenström macroglobulinemia: biology, genetics, and therapy
... The initial rapid and profound decrease in IgM levels (median time to response, 4 weeks) was not matched by a decrease in bone marrow involvement, which suggests that ibrutinib affects IgM secretion rather than cell ... See full document
10
<p>Rituximab-based combination therapy in patients with Waldenström macroglobulinemia: a systematic review and meta-analysis</p>
... To the best of our knowledge, this pooled analysis is the first one to explore the efficacy and safety of rituximab-based combination therapy in patients with symptomatic WM. We have every reason to believe that ... See full document
16
<p>Good Profile of Efficacy/Tolerance of Bortezomib or Idelalisib in Waldenström Macroglobulinemia Associated with Acquired Von Willebrand Syndrome</p>
... Waldenström macroglobulinemia (WM) is a challenging ...their therapy to idelalisib, a targeted oral therapy that inhibits phosphatidylinositol 3-kinase isoform-delta (PI3KD), which is part of the ... See full document
6
New developments in the management of Waldenström macroglobulinemia
... A subset analysis of a Phase III, open-label trial by Rummel et al, comparing bendamustine in combination with ritux- imab (BR) with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP), showed ... See full document
11
Candidate genes of Waldenström’s macroglobulinemia: current evidence and research
... Although WM is incurable, it is typically character- ized by an indolent clinical course. For this reason, active treatment is not recommended until symptoms arise and/ or end organ damage ensues. In particular, ... See full document
10
Evo Devo: the long and winding road
... The most exciting and far-reaching discovery of modern Evo- Devo was the finding that many developmental genes are conserved among deeply divergent taxa. So, organisms as different as nema- todes, flies and mammals use ... See full document
9
A Comprehensive Genetic and Clinical Evaluation of Waardenburg Syndrome Type II in a Set of Iranian Patients
... 2 Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences,.. Isfahan, Iran.[r] ... See full document
7
Managing Sjögren’s Syndrome and non-Sjögren Syndrome dry eye with anti-inflammatory therapy
... A common therapy for dry eye has been the use of artificial tears. These provide temporary relief of symptoms in most cases. There are several artificial tear products on the market with different compound ... See full document
12
Is the Biology of M. chitwoodi and M. hapla Reflected in Their Genomes?
... response for targeting pathogen effectors which manipulate plant immune system, and (3) amplification of signaling pathways including salicylic acid (SA)- and jasmonic acid (JA)- pathways which could contribute to both ... See full document
189
PECTORALIS MUSCLE FORCE AND POWER OUTPUT DURING FLIGHT IN THE STARLING
... GOSLOW, JR Section of Population Biology, Morphology and Genetics, Division of Biology and Medicine, Brown University, Providence, RI02192, USA Accepted 7 November 1991 Summary Force rec[r] ... See full document
18
Understanding Quantitative Genetics in the Systems Biology Era
... quantitative genetics has undergone a striking expan- sion in the last ...quantitative genetics mainly focuses on evaluating the coupling association of the polymorphic DNA sites with the phenotypic ... See full document
10
Glucokinase as pancreatic beta cell glucose sensor and diabetes gene
... Introduction This article is an account of research in physiological chemistry, molecular biology, and human genetics that developed the concept that glucokinase GK' of the insulin-secre[r] ... See full document
8
Cross idiotypic antigens among monoclonal immunoglobulin M from patients with Waldenström's macroglobulinemia and polyneuropathy
... macroglobulinemia and a polyneuropathy shared cross-idiotypic antigenic determinants as demonstrated by hemagglutination and hemagglutination inhibition experiments as well as by precipitin reactions. This ... See full document
6
Experience of Introduction of the Online Course in Biology for Pharmacy Students in Ukraine
... It should be noted that in all on-line courses of the National University of Pharmacy the board made an anonymous on-line questionnaire survey of the students. In particular, students of the courses were offered to ... See full document
7
Volume 21 - Article 16 | Pages 469–502
... be considered: downward transfers of wealth and support (i.e., from grandparents and parents to children), by improving the conditions and life opportunities of children, should over time increase the fitness of ... See full document
36
Biochemistry, genetics and molecular biology of nitrite reduction in barley
... 5m M, bu t nitrite reductase activity decreases at higher nitrite concentrations, followed by plant death w ithin a few days (Joy, ...barley m utants defective in nitrate reduction, hence unable to ... See full document
355
Membrane Architecture and Dynamics (EuroMEMBRANE)
... including genetics, systematic biological phenotyping, chemical synthesis of sterols and sphingolipids, lipid imaging in living cells/tissues and mass spectrometry for lipid analysis will be ... See full document
8
ON THE BIOLOGY AND GENETICS OF SCAPTOMYZA GRAMINUM FALLEN (DIPTERA, DROSOPHILIDAE)
... PATTERSON (written communication) has found that using a mixture of agar and Chondrus as a jelling agent makes a softer food into which the larvae can dig. The chief difficul[r] ... See full document
14
The State of Federal Research Funding in Genetics as Reflected by Members of the Genetics Society of America
... Most of the GSA PI respondents have active federal research funding: 39.0% have one grant, 24.3% have two, and 10.9% have three or more. Although the sizes of grants vary and the funding needed in different fields varies, ... See full document
7
<p>Essential Thrombocythaemia with Concomitant Waldenström Macroglobulinaemia: Case Report and Literature Review</p>
... was no signi fi cant dysplasia. His biochemistry pro fi le revealed a slightly raised total globulin level of 41.9g/L (normal range: 20 – 40g/L), uric acid: 507 μ mol/L (normal range: 208 – 428 μ mol/L) and lactate ... See full document
5
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