[PDF] Top 20 Year in review 2013: Critical Care metabolism

... The management of stress-related hyperglycemia has been the focus of several prospective studies that yielded results still fueling a hot debate [1,2]. The concept of the three domains of dysglycemia (hyperglycemia, ... See full document

... Assessment of disease severity in respiratory failure Although a significant number of patients with respiratory failure die or require prolonged mechanical ventilation, the tools for predicting mortality and morbidity ... See full document

... advanced care should increase patient survival; however, more research involving homogenous models, while also addressing societal cost, appears neces- sary for the HEMS ... See full document

... Infectious complications, particularly in the respiratory tract of critically ill patients, are related to increased mortality. Severe infection is part of a multiple system illness and female patients with severe sepsis ... See full document

... this review is to summarise the relevant find- ings of research articles that were published in 2013 in Critical Care and other relevant ... See full document

... of critical illness associated with death and dis- ...of care for these patients are very high and research on AKI is thus focusing on prevention, early detection and ...and critical care ... See full document

... intensive care units (ICU), adult and pediatric cardiac surgery, and (last but not least) the relatively high portion formed by post-operative general surgery ... See full document

... Although both AVP and terlipressin exert vasopressor properties, distinct pharmacokinetic diff erences as well as pharmacodynamic diff erences between these two drugs must be taken into account: the half-life of ... See full document

... In the base case analysis, the authors assumed a high attributable mortality of ICU-acquired candidaemia (40%) and an overly optimistic risk reduction (52%) in mortality with appropriate timely therapy. Of note, in the ... See full document

... Another review of 14 articles on the value of urinary bio- markers in the specific setting of septic AKI [12] showed that a promising future is apparently reserved for ... See full document

... in critical illness resulting from hemorrhagic shock, based on the assumption that it is indeed directly related to the degree of mitochondrial dysfunction in hemorrhagic ... See full document

... 2008 Critical Care article in regard to this subject, Soldatos and colleagues [7] used an intra- parenchymal catheter to directly measure ICP and found that an ONSD of ... See full document

... Artefact is one of the potential problems of echocardiography, particularly TTE. Karabinis and colleagues [23] conducted an ultrasound study to investigate echocardiographic artefacts in mechanically ventilated patients ... See full document

... In a pig model of ALI induced by lung lavage and high airway pressure ventilation, the difference in lung volume was measured from pressure-volume curves and the changes in EELV were ass[r] ... See full document

... MRSA is an important cause of pneumonia in the commu nity and often is a severe illness, needing ICU management. Moran and colleagues [20] defi ned the incidence and risk factors for this infection in a pros- pective ... See full document

... significant year in Critical Care, with a number of landmark papers being published in sepsis research in this journal and in other ...past year. The year started off on a positive note ... See full document

... of critical care nephrology accepted or published during 2008 in Critical Care and, when considered relevant or directly linked to this research, in other ... See full document

... duration of time in which free drug concentrations remain above the MIC during the dosing interval (ƒT >MIC). Time-dependent antimicrobials – β-lactams, carbapenems, and vancomycin – are hydrophilic sub- stances, and ... See full document

... Pulmonary secretions frequently impair liberation from mechanical ventilation and often contribute to post- extubation respiratory failure. Impairment in the cough mechanism due to endotracheal intubation, muscular ... See full document

... citrate metabolism leads to citrate accumulation and in- creases the T/I Ca 2+ ratio with normal Ca ion ...of critical illness score, were sig- nificantly higher in the last tertile ... See full document