Clinical implications

Difficulties in emotion regulation may critically contribute to the development of dissociation in vulnerable traumatized individuals (Vermetten & Spiegel, 2014). Dissociation can provide a subjective detachment from the self and / or environment and therefore be a helpful self- protectivce strategy in traumatic or otherwise stressful situations (Spiegel & Cardena, 1991). Present findings suggest that this may have a high cost. Dissociation can hinder the integration of salient information in consciousness and autobiographical memory; such information may then be processed and stored as isolated somatosensory elements, which later re-occur in the form of intrusive flashback memories (Ehlers et al. 2004; Krause-Utz & Elzinga, in press). By hindering the integration of traumatic or otherwise salient events in autobiographical memory, dissociation also interferes with identity, the development of a stable sense of self and understanding of who we are (Schauer & Elbert, 2010; Spiegel et al., 2011; Waters, 2014). Dissociation may not only dampen negative but also positive emotions and thereby lead to chronic feelings of emptiness and inner isolation (Lanius, 2015). Diminished emotional responsiveness may in turn lead to conflicts in close relationships and critically affect parenting (Lanius, 2015). All these maladaptive effects of dissociation can contribute to the development and maintenance of psychiatric disorders, such as PTSD and BPD (Brewin 2001; Brewin, Dalgleish, & Joseph, 1996; Ehlers & Clark 2000; Van der Kolk et al. 1996) and should therefore be taken into account in therapy. It has been shown that individuals who learned to dissociate in traumatic situations, will more likely dissociate in other stressful situations, e.g., during exposure therapy (Frewen & Lanius, 2006). Basic learning mechanisms, such as negative reinforcement (reduction of negative emotions), may explain why the probability is high that dissociative responses reoccur as an automatic response to environmental threat and generalize across situations. These processes may happen unconsciously. Thus, psychoeducation about these mechanisms may help patients to gain more insight into adaptive and maladaptive effects of dissociation.

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Interventions that are aimed at helping individuals to reduce dissociative processes at moments when they are disruptive (and therefore maladaptive) are part of many existing psychotherapeutic treatments, such as Dialectical Behavioral Therapy (DBT) (Bohus et al., 2013; Linehan, 1993), Schema Focused Therapy (Sempertegui, Karreman, Arntz, & Bekker, 2013; Young, Klosko, & Weishaar, 2003), Cognitive Processing Therapy (CPT) (Resick & Schnicke, 1993), or Eye-Movement-Desensitization-and-Reprocessing Therapy (EMDR) (Shapiro, 2010; Shapiro & Maxfield, 2002). These techniques include mindfulness training and breathing and grounding techniques, such as motoric balance exercises (Bohus et al., 2013). Patients who tend to over-modulate their emotions may further benefit from trainings in emotional awareness and alternative stress regulation, e.g., how to tolerate painful emotions and how to experience more positive emotions (Lanius, 2015). Computerized interventions, which involve a continuous monitoring of dissociative states and suggestions for anti- dissociative skills, were found to improve the self-application of these skills during self- administered exposure exercises in the context of trauma therapy (Görg et al., 2016). Computerized interventions, aimed at improving executive control, might have a similar effect on the self-application of anti-dissociative skills.

So far, the role of neuroimaging in therapy research on dissociation has been limited. In part, there is still controversy about dissociative disorders and their neurobiological underpinnings (Lanius, 2015). Over the last years, neuroimaging studies have mainly focused on identifying neural processes, altered by dissociation, and already provided more and more insight into its possible neural underpinnings. So far barely anything is known about possible neural mechanisms of change related to dissociation. Yet, over the coming years, neuroimaging techniques might be used to translate the existing clinical and neurobiological knowledge into experimental interventions, such as real-time fMRI (neurofeedback training) (Lanius, 2015). At first, more studies are needed to investigate whether certain brain regions show changes in activity after the reduction of dissociative symptomatology, and whether they may be suitable targets for such add-on interventions. The combination of dissociation induction with symptom provocation may be a helpful step in this relationship.

8.6. Conclusion

The present research suggests that dissociative symptoms can have detrimental effects on cognitive functioning and may influence emotional and self-referential processing in BPD. Therefore, dissociative symptoms should be taken into account in future neuropsychological and neuroimaging studies in BPD, even when it is not the major focus of research.

While the precise mechanisms underlying stress-related dissociation in BPD remain elusive, neuroimaging findings reported here point to reduced activity in limbic (amygdala, posterior cingulate), temporal (inferior and superior temporal gyrus, fusiform gyrus), parietal (inferior and superior parietal lobe), and occipital areas (cuneus, fusiform gyrus, lingual gyrus), and increased activity in frontal areas (inferior frontal gyrus, dlPFC) in BPD patients with elevated dissociative symptoms. The present research further suggests that altered interactions between the amygdala and regions implicated in self-referential processing, cognitive control, visual perception, and sensory gating may play a role in dissociation in BPD. Further research with larger sample sizes and clinical control groups is needed to clarify whether the above-mentioned patterns can be replicated in other samples of BPD patients or are confounded by differences in sample characteristics (e.g., gender, trauma history, comorbidities, and psychotropic medication). In general, the complexity of BPD may be best understood by combining multiple measurements of multiple psychopathological dimensions. Future studies in BPD may combine different neuroimaging techniques (e.g., resting-state and task-related fMRI, seed-based correlations and ICA) with subjective, behavioral, and psychophysiological measurements (e.g., heart rate) to further improve the understanding of this severe and complex disorder.

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