Key points and implications
5.5 Conclusions and Implications for policy
1. Studies to establish normal values of NT-proBNP in African children.
2. Studies involving a larger sample size of PEM subjects comparing cardiac dysfunction and NT-proBNP levels in hospitalized children with PEM versus those receiving community based therapies.
67
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APPENDIX I
Patient information leaflet and statement of informed consent
I am Nnenna Kalu, a senior registrar in the department of paediatrics of Lagos State University Teaching Hospital, LUTH.I am interested in checking the hearts of children who are not growing as well as their age-mates and will like your child to be part of this study in our hospital. Any information you provide will be treated with utmost confidentiality.
The reason for carrying out this study is because the hearts of children who are not feeding well and therefore not growing as they should can be affected and not work well. This can make the child very sick, but early detection and treatment may help prevent the bad effects and also prevent death.
I will need to conduct a physical examination on your child, after which I will do an ultrasound of the heart, called echocardiography. A small amount of blood will also be taken from your child to run some laboratory tests. . If your child belongs to the control group, which means he/she is feeding well and growing as well as he/ she should, he/she will have only their blood samples taken. The tests will be conducted free of any costs to you, and the results of the tests will be communicated to you. It is not compulsory to participate in this study, and refusal to participate will not in any way affect your child in terms of health care services in this hospital. If you choose to participate you can change your mind and opt out of the study at any time.
The risk of this study to your child does not go beyond the pain your child will feel while being pricked during blood specimen collection.
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In the event you want to ask some questions about this study, I can be reached at the Department of Paediatrics, LUTH or you may contact me on 08033043080. If you agree that your child should participate in this study, please sign below. Thank you.
………..
Dr N.N Kalu
Patients name: ……… ………..
Parent / Guardians name………
Signature of parent / Guardian………..
Date: ………..
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APPENDIX II
STUDY PROFORMA
Demographic data Name:
Age:
Gender:
Contact number:
Rank in birth order:
Mother’s name and occupation:
Father’s name and occupation:
Clinical data Weight (kg):
Height (cm):
Oedema: yes No z - scores:
Weight for Height z – scores:
Weight for age z – scores:
Height for age z – scores:
Physical examination Respiratory rate:
Heart rate:
Dyspnea: Yes No Diaphoresis: Yes No Cardiomegaly; Yes No Hepatomegaly: Yes No Modified Ross scores: