DO I HAVE TO TAKE PART?
CONTACT FOR FURTHER INFORMATION
If you experience any problems during the study, you may withdraw at any stage. The doctors involved in the study, Dr Salem and Dr de Silva, will be available by telephone during working hours (020 8383 2820). The hospital switchboard (020 8383 1000) has full contact details for all the doctors involved in the study and can reach them at any time outside normal working hours.
If you agree to take part in the trial, you will also be given the mobile phone numbers of the doctors.
153 APPENDIX V – DETAILED NUTRITIONAL BREAKDOWN OF THE SET BREAKFAST SERVED ON ALL “FED” VISITS
All participants were asked to eat the breakfast in its entirety and there was no instance (any subject on any “fed” visit) of this request not being complied with.
Values for Breakfast portions
WEIGHT
(g) MENU Protein Fat CHO Kcal KJ
40 Bran Flakes (Kellogs) 4 0.8 26.8 130
170 Semi-skimmed milk (Sainsburys) 5.78 2.89 8.5 83.3 350.2
220 Orange Juice 1.1 0 20.02 92.4 391.6
80 Wholmeal Bread (Hovis) 8 2.16 30.24 172.8 730.4
20 Margarine (flora original) 0 11.8 0 106 436
20 Jam (Robertson strawberry) 0 0 13.4 53.6 227.8
25
Cheese (2 x Leerdamer original
slices) 6.75 7 0 89.5 372.5
Total 25.63 24.65 98.96 727.6 2508.5
% Composition 14.1 30.5 51.0
154 PUBLICATIONS AND PRESENTATIONS RELATED TO THE WORK IN THIS THESIS
De Silva A*, Salem V*, Long CJ, Makwana A, Newbould RD, Rabiner EA, Ghatei MA, Bloom SR, Matthews PM, Beaver JD, Dhillo WS. The gut hormones PYY 3-36 and GLP-1 7-36 amide reduce food intake and modulate brain activity in appetite centers in humans. Cell Metab. 2011 Nov 2;14(5):700-6. * joint first authorship Salem V*, De Silva A*, Matthews PM and Dhillo WD. Imaging the neuroendocrinology of appetite. Adipocyte 1:1, 1–5; January 2012 * joint first authorship
De Silva A*, Salem V*, Matthews PM and Dhillo WD. The use of functional MRI to study appetite control in the CNS. Exp Diabetes Res. 2012:764017; May 2012 * joint first authorship
Salem V, De Silva A, Long CJ, Makwana A, Newbould R, Rabiner E, Ghatei, M, Bloom SR, Matthews PM, Beaver J, Dhillo WS. Co-administration of the gut hormones PYY and GLP-1 to human volunteers reduces food intake and brain activation in appetite centres.
Oral Presentation at Society for Endocrinology BES 2011 .
Oral presentation at Association of Physicians of UK APAM 2011.
Poster presentation nominated for Presidential Poster Competition at American Endocrine Society ENDO 2011.
Poster presentation winner of Diabetes and Endocrinology section, Academy of Medical Sciences/RCP meeting for Clinician Scientists 2012.
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