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Discriminant validity: Studies o f the performance of a diagnostic interview across di fferent comparison groups

Costello et al (1985) looked at the performance o f the DISC in comparing different

treatment groups. The DISC was administered to 40 psychiatric out-patients and 40

paediatric controls aged between 7 and 11. Using the child interview and mild or severe

diagnoses, the DISC correctly identified 25% of the paediatric referrals and 95% of the

psychiatric group. Using the child interview and severe diagnoses only, the DISC

identified 85% o f the paediatric referrals and 45% of the psychiatric referrals. The

authors reported that if one only considers the severe diagnoses the sensitivity (i.e.ability

to identify “cases”) o f the DISC was 45% overall. The specificity o f the DISC (i.e.ability

to correctly identify “non cases”) using the severe diagnoses was 80%. Using the severe

or mild/moderate diagnoses the DISC sensitivity was 95% but the specificity was low at

25%. The low specificity appeared to be because the children in both groups reported

many mild disorders.

The d i s c’s ability to discriminate between the two treatment groups was more clear with the symptom complex scores. The psychiatric group had higher scores with regard

to the combined anxiety scale (although there were no significant differences between the

groups on Overanxious Disorder), Fears and Phobias, (although not Social Phobia)

Schizoid/Psychotic scores. Affective symptoms and the total number o f symptoms. There

were, however, no significant differences with regard to Obsessive Compulsive

symptoms. Costello et al (1985) argued that the DISC’s ability to discriminate between

the treatment groups was clear for the DISC symptom complexes but less clear for the

diagnoses themselves. They pointed out that when the DISC algorithm followed DSM

III diagnostic criteria very rigidly and the mild/moderate level o f diagnosis was in

more stringent set of criteria were used to assign the diagnosis, a significant difference

between the groups was observed. The authors suggested that the classification on which

the DISC interview was based required revision and that these data indicate that DSM

III criteria have limited validity.

Psychometric data on the detection o f eating disorder by diagnostic interviews has only

been published in one paper. A study on the validity the DISC-R was conducted by

Fisher et al (1993). The aim of the study was to investigate the sensitivity of the DISC-R

in its detection o f more rare disorders. The authors recruited the following groups from

treatment centres specialising in the treatment of a number o f disorders:

i)61 in-patients and 15 out-patients with either DSM III-R Anorexia or Bulimia Nervosa

and between 12 and 17. The diagnosis was done by non standardised clinical assessment.

ii)l 1 out-patients with DSM III-R Major Depressive Disorder aged between 9 and 17.

The diagnosis was done by a clinician using the K-SADS. The mean duration between

the K-SADS and DISC-R was 28 days.

iii)17 patients with DSM III-R Obsessive Compulsive Disorder (patient status not

specified). The diagnosis was made by a non standardised clinical assessment.

The authors also recruited patients with TIC Disorders and Substance use Disorders.

Data on these patients have not been included here as they are not within the remit o f the

present thesis.

Fisher et al (1993) reported that the sensitivity of the DISC-R in a clinical setting was

adequate for Anorexia Nervosa, ( 67% ), Bulimia Nervosa (75%) and Obsessive

Compulsive Disorder (65%). However, the DISC-R had poor sensitivity for the

detection o f Major Depressive Disorder (18%). The authors reported that it became

apparent that the wording of the Major Depressive Disorder items were complicated and

needed to be revised. They pointed out that the DISC-R was different from the K-SADS

and DICA in that the DISC-R required that some of the symptoms co-occurred during a

the DISC-R was poorer than other interviews in the detection o f Major Depressive

Disorder as the other validity studies have tended to look at affective disorders in general

rather than specific diagnoses.

Hodges et al (1982) compared nine o f the CAS symptom complex scores across three

groups, 32 out-patients and 18 in-patients with Behavioural Disorders and 37 “normal”

controls. All three groups were aged between 7 and 14. The authors reported that there

were differences between the scores o f the three groups for eight o f the nine symptom

complexes compared. In terms of the symptom complexes that relate to the emotional

disorder, the in-patients had higher scores than the out-patients who in turn had higher

scores than the controls. The in-patients had higher scores than the out-patients and

controls combined, although there were no significant differences between the latter two

group on the Separation Anxiety symptom complex. Lastly with regard to the

Overanxious Disorder symptom complex, the in-patients and out-patients combined had

higher scores than the controls and the in-patients had higher scores than the out-patients

and controls combined. These data suggests that the depression symptom complex was

able to discriminate between all three groups and discrimination between in-patients and

controls was possible for the Separation Anxiety and Overanxious Disorder symptom

complexes o f the CAS. Hodges et al (1982) reported that the CAS total score was able

to identify 72% of the in-patients, 41% o f the out-patients and 84% of the controls. This

corresponded to an overall correct classification rate o f 66%.