3.8. Screen Printing Technique
3.8.2 Effect of Coating Thickness on Pool Boiling Performance using Screen
104
CHAPTER SIX
CONCLUSION , LIMITATION AND RECOMMENDATION 6.1. CONCLUSIONS
1. ProBNP levels were significantly higher in stroke patients than in the age and gender- matched controls.
2. Haemorrhagic stroke cases had significantly higher admission ProBNP levels than the acute ischaemic stroke cases.
3. Elevated ProBNP levels positively correlated with stroke severity in both ischaemic and haemorrhagic stroke patients.
4. Elevated ProBNP levels was associated with 30-day case fatality post-stroke in both ischaemic and haemorrhagic stroke patients.
5. Elevated ProBNP levels were associated a poor functional outcome.
6.2.. LIMITATIONS
1. The main limitation of this study is the small size ,a greater sample size may be required as the small sample size may limit generalisations.
105
2. Stroke patients with high Pro-BNP should be activey monitored in a stroke unit for better outcome .
3. Furthermore, a comparison of ProBNP levels between ischaemic and haemorrhagic stroke in studies with larger sample sizes is required
REFERENCES
1. Global status report on noncommunicable diseases 2010. Geneva, World Health Organization, 2011
2. Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data.
Lancet 2006; 367:1747-57.
3. W. J. M. Scholte R. J. de Haan, P. T. Rijnders, ; M. Limburg; G. A. M. van den Bos, The Burden of Caregiving in Partners of Long-Term Stroke Survivors. Stroke. 1998;
29:1605-1611.
4. Anderson CS, Linto J, Stewart-Wynne EG. A population-based assessment of the impact and burden of caregiving for long-term stroke survivors. Stroke.
1995s;26(5):843-9.
5. Mutai H1, Furukawa T, Araki K, Misawa K, Hanihara T. Long-term outcome in stroke survivors after discharge from a convalescent rehabilitation ward. Psychiatry Clin Neurosci. 2013 ;67(6):434-40.
6. Rosamond W, Flegal K, Furie K Go A, Greenlund K, Haase N, et al. Heart disease and stroke statistics—2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2008;117: e 25-146.
7. European cardiovascular disease statistics 2008. European Heart Network, Brussels.
106
8. Wolfe C D, Giroud M, Kolominsky-Rabas P, Dundas R, Lemesle M,Heushmann P et al. Variations in stroke incidence survival in 3 areas of Europe . European registry of stroke collaboration .2000 ;31(9):2074-9.
9. Bamford J, Dennis M, Sandercock P,Burn J And Warlow J C .the frequency timing and causes of death within 30 days of a first stroke : the oxfordshire community stroke project . Neuro Neurosurg Psychiatry. 1990, 53 (10): 8243-829
10. Lovelock CE, Molyneux AJ, Rothwell PM, On Behalf Of Oxford Vascular Study.
Change in Incidence And Aetiology Of Intracerebral Hemorrhagein Oxfordshire Uk, Between 1981 And 2006, A Population Based Study. Lancet Neurology 2007,6: 487-93
11. Dalal P.M,Malik S , Bhattercharjee M , Trivedi N.D.,Vairale J,Bhat P et al. Population Based Stroke Survey In Mumbai , India : Incidence And 28-Day Case Fatality . Neuroepidemiuology . 2008,31(4):254-61.
12. Cabral N.l , Goncalves A.R, Longo Al , Moro C.H.C, Costa G, Amaral C.H .Trends in stroke incidence , mortality and case fatality rates in Joinville,Brazil.1995-2006.J Neurol Neurosurg Psychiatry. 2009; 80(7): 749-754
13. Osuntokun BO, Bademosi O, Akinkugbe OO, Oyediran AB, Carlisle R; Incidence of stroke in an African City: results from the Stroke Registry at Ibadan, Nigeria, 1973-1975. Stroke. 1979 ;10(2):205-7
14. Danesi M, Okubadejo N.U. Ojini F.I. Incidence and 30-Day Case Fatality Rate of First Ever Stroke in Urban Nigeria: The Prospective Community Based Epidemiology of Stroke in Lagos(EPISIL) phase II results. Neuroepidemiology 2007; 28 (4): 216-223.
15. Ojini F.I, Ogun S.A., Danesi M.A., Thirty Day Case Fatality of Stroke at The Lagos University Teaching Hospital Nig Quart J Hosp Med 2004; 14:64-66.
107
16. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R; Prospective Studies Collaboration. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies.Lancet.2002,14;360(9349):1903-13. Erratum in: Lancet. 2003 22;361(9362):1060.
17. Watila M., Nyandaiti Y, Ibrahim A, Balarabe S. A., Gezawa I. D., Bakki B.et al . Risk factor profile among black stroke patients in Northeastern Nigeria. Journal of Neuroscience and Behavioural Health Vol. 4(5), pp. 50-58, May 2012
18. Marler JR, Tilley BC, Lu M, Brott TG, Lyden PC, Grotta JC. Early stroke treatment associated with better outcome: the NINDS rt-PA stroke study Neurology. 2000 Dec 12;55(11):1649-55.
19. Broderick J, Connolly S, Feldman J. Guidelines for Management Of Spontaneous Intracerebral Hemorrhage. Circulation 2007; 116(16): E 391-413
20. Owolabi L.F, Nagoda M N.U. Factors associated with death and predictors of one-month mortality from stroke in Kano, Northwestern Nigeria. Neurosci Rural Pract.
2013; 4(Suppl 1): S56–S61.
21. Black-Schaffer RM, Winston C Age and functional outcome after stroke. Top Stroke Rehabil. 2004 Spring;11(2):23-32.
22. Knoflach M, Matosevic B, Rücker M, Furtner M, Mair A, Wille G et al Functional recovery after ischemic stroke--a matter of age: data from the Austrian Stroke Unit Registry. Neurology. 2012 ;78(4):279-85.
23. Ji-Sun K ,Kyung-Bok L , Hakjae R, , Moo-Young A, , and Hye-Won H. Gender Differences in the Functional Recovery after Acute Stroke J Clin Neurol.2010; 6(4):
183–188.
108
24. Wyller TB, Sødring KM, Sveen U, Ljunggren AE, Bautz-Holter E. Are there gender differences in functional outcome after stroke? Clin Rehabil. 1997(2):171-9.
25. Bhatia RS, Garg RK, Gaur SP, Kar AM, Shukla R, Agarwal A, Predictive value of routine hematological and biochemical parameters on 30-day fatality in acute stroke.
Neurol India. 200452(2):220-3.
26. Chamorro A, Vila N, Ascaso C, Saiz A, Montalvo J, Alonso P, et al. Early prediction of stroke severity. Role of erythrocyte sedimentation rate. Stroke 1995; 26:573-6.
27. Wahab K.W., Okubadejo N. U., Ojini F.I., Danesi M.A,Predictors Of Short Term Intrahospital Case Fatality following First Ever Acute Ischemic Stroke In Nigerians. J Coll Physicians Surg Pak. 2008; 18(12): 755-8.
28. Kes VB, Solter VV, Supanc V, Demarin V., Impact of hyperglycemia on ischemic stroke mortality in diabetic and non-diabetic patients. Ann Saudi Med. 2007 t;27(5):352-5.
29. Capes SE, Hunt D, Malmberg K, Pathak P, Gerstein HC. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke.
2001 Oct;32(10):2426-3
30. Myrsini MA;Ouzounelli MD; Gwen C. , Uma RN,. Diringer MN, Reaven NL, et al.
Impact of Fever on Outcome in Patients with Stroke and Neurologic Injury: A Comprehensive Meta-Analysis
31. Diringer MN, Reaven NL, Funk SE, Uman GC. Elevated body temperature independently contributes to increased length of stay in neurologic intensive care unit patients. Crit Care Med. 2004; 32: 1489–1495.
32. Hindfelt B.Acta Neurol Scand. The prognostic significance of subfebrility and fever in ischaemic cerebral infarction.1976 ;53(1):72-9.
109
33. Terént A, Andersson B. The prognosis for patients with cerebrovascular stroke and transient ischemic attacks. Ups J Med Sci. 1981;86(1):63-74.
34. Weir C J. ;. Muir S W, Walters M R. and Lees KR.. Serum Urate as an Independent Predictor of Poor Outcome and Future Vascular Events after Acute Stroke, Stroke.
2003; 34: 1951-1956
35. Abubakar SA, Okubadejo NU, Ojo OO, Oladipo O, Ojini FI, Danesi MA. Relationship between admission serum C-reactive protein and short term outcome following acute ischaemic stroke at a tertiary health institution in Nigeria. Niger J Clin Pract.
2013;16(3):320-4.
36. Vibo R1, Kõrv J, Roose M, Kampus P, Muda P, Krihk P. et al Acute phase proteins and oxidised low-density lipoprotein in association with ischemic stroke subtype, severity and outcome. Free Radic Res. 2007, 41(3):282-7.
37. Okubadejo N.U., Oladipo O.O., Adeyomoye A.A., Awosanya G.O., and Danesi M.A.Exploratory study of plasma total homocysteine and its relationship to short-term outcome in acute ischaemic stroke in Nigerians. 1. BMC Neurol. 2008; 8: 26.
38. Nogami M, Shiga J, Takatsu A, Endo N, Ishiyama I. Immunohistochemistry of atrial natriuretic peptide in brain infarction. Histochem J. 2001 ;33(2):87-90.
39. Katoh C, Osanai T, Tomita H, Okumura K.J. Brain natriuretic peptide is released from human astrocytoma cell line U373MG under hypoxia: a possible role in anti-apoptosis.
Endocrinol. 2011 ;208(1):51-7.
40. Reynolds MA, Kirchick HJ, Dahlen JR, Anderberg JM, McPherson PH, Nakamura KK, et al Early biomarkers of stroke Clin Chem. 2003;49(10):1733-9.
41. Bunevicius A1, Kazlauskas H, Raskauskiene N, Mickuviene N, Ndreu R, Corsano E et al Role of N-Terminal Pro-B-Type Natriuretic Peptide, High-Sensitivity C-Reactive
110
Protein, and Inteleukin-6 in Predicting a Poor Outcome after a Stroke.
Neuroimmunomodulation. 2015.
42. Jensen JK, Mickley H, Bak S, Korsholm L, Kristensen SR. Serial measurements of N-terminal pro-brain natriuretic peptide after acute ischemic stroke. Cerebrovasc Dis.
2006;22(5-6):439-44.
43. Tu WJ, Dong X, Zhao SJ, Yang DG, Chen H. Prognostic value of plasma neuroendocrine biomarkers in patients with acute ischaemic stroke J Neuroendocrinol.
2013; 25(9):771-8
44. WHO MONICA Project Investigators. The World Health Organization MONICA Project (Monitoring trends and determinants in cardiovascular disease). J Clin Epidemiol 41, 105-114. 1988.
45. Sacco RL, Kasner SE, Broderick JP, Caplan LR, Connors JJ, Culebras A, et al; An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association.
Stroke. 2013 ;44(7):2064-89.
46. Bamford J, Sandercock P, Dennis M, Warlow C, Jones L, McPherson K et al. A prospective study of acute cerebrovascular disease in the community: The Oxfordshire Community Stroke Project 1981-86. 1. Methodology, demography and incident cases of first-ever stroke. J Neurol.Neurosurg.Psychiatry 1988;51:1373-80
47. Oni A. O.; Eweka A. O.; Otuaga P. O.; Prefa, V. The Incidence and Pattern of Stroke in Bayelsa State, Nigeria. Internet Journal of Third World Medicine;2009, Vol. 8 Issue 1, p18
48. Bonita R, Beaglehole R. Recovery of motor function after stroke. Stroke 1988;
19:1497-500.
111
49. Ojagbemi A, Owolabi M. Predictors of functional dependency after stroke in Nigeria.
J Stroke Cerebrovasc Dis. 2013 ;22(8):e381-7.
50. Ogun SA1, Ojini FI, Ogungbo B, Kolapo KO. Stroke in south west Nigeria: a 10-year review. Stroke. 2005 ;36(6):1120-2.
51. Desalu OO1, Wahab KW, Fawale B, Olarenwaju TO, Busari OA, Adekoya AO, et al.A review of stroke admissions at a tertiary hospital in rural Southwestern Nigeria.
Ann Afr Med. 2011 ;10(2):80-5. doi: 10.4103/1596-3519.82061
52. Onwuchewa, A., H. Bellgam, Asekomeh G. "Stroke at The University of Port Harcourt Teaching Hospital, Rivers State, Nigeria." Trop Doct 2009;39(3): 150-2.
53. Owolabi L.F, Nagoda M. Stroke in Developing Countries: Experience at Kano, Northwestern Nigeria. Sudan Journal of Medical Sciences. Volume 7, Number 1 (2012) , 9-14
54. Alkali NH, Bwala SA, Akano AO, Osi-Ogbu O, Alabi P, Ayeni OA. Stroke risk factors, subtypes, and 30-day case fatality in Abuja, Nigeria. Niger Med J. 2013
;54(2):129-35.
55. Eze C.O., Agu CE, Kalu UA, Maduanusi CA, Nwali ST, Iguenyi C et al The Pattern and Presentation of Stroke in Federal Teaching Hospital Abakaliki (FETHA)
South-East Nigeria. Journal of Biology, Agriculture and Healthcare www.iiste.org ISSN 2224-3208 (Paper ISSN 2225-093X (Online) Vol.3, No.11, 2013
56. Ojini FI, Danesi MA et al The Pattern of Neurological Admissions at The Lagos University Teaching Hospital. Nigerian Journal of Clinical Practice 2003, vol. 5 38-41.
57. Talabi OA. A 3-year review of neurologic admissions in University College Hospital Ibadan, Nigeria. West Afr J Med. 2003; 22:150–1.
58. Chapp-Jumbo EN. Neurological admissions in the Niger Delta Area of Nigeria- A ten-year review. African Journal of Neurological Sciences 2004; 23(1): 14-20,11
112
59. Oparah S. K., Njideofor U.N, . Ezedinachi E.N.U Pattern of Outpatient Neurological Presentations at A Tertiary Health Facility in Southern Nigeria: A 2 Year Review At The University Of Calabar Teaching Hospital, Calabar, Nigeria. Pioneer Medical Journal Vol. 3, No. 6, , 2013.
60. Philip-Ephraim E.E., Eyong K.I., Oparah S.K., Williams U, Udonwa N., Abraham N et al.Profile of Neurologic Emergencies At The Accident & Emergency Department of A Tertiary Hospital in South Nigeria. Journal of Neurological Sciences (Turkish) 2013, Volume 30, Number 1, Page(s) 072-080
61. Abubakar SA, Sabir AA. Profile of stroke patients seen in a tertiary health care centre in Nigeria. Annals of Nigerian Medicine. 2013;7(2):55.
62. Okunoye C, Asekomeh G., Iyagba A., and Onwuchekwa A. A Prospective Hospital Based Study. Neurology 6, 2015 vol. 84 no. 14 Supplement P1.074
63. Okon M, Adebobola NI, Julius S, Adebimpe O, Taiwo AO, Akinyemi A, et al . Stroke incidence and case fatality rate in an urban population. J Stroke Cerebrovasc Dis. 2015
;24(4):771-7.
64. Maredza M, Bertram MY, Tollman SM. Disease burden of stroke in rural South Africa: an estimate of incidence, mortality and disability adjusted life years. BMC Neurol. 2015 12;15:54.
65. Walker R, Whiting D, Unwin N, Mugusi F, Swai M, Aris E, et al Stroke incidence in rural and urban Tanzania: a prospective, community-based study. Lancet Neurol.
2010;9(8):786-92.
66. Palm F, Urbanek C, Rose S, Buggle F, Bode B, Hennerici MG, , et al. Stroke Incidence and Survival in Ludwigshafen am Rhein, Germany: The Ludwigshafen Stroke Study (LuSSt). Stroke. 2010 ;41(9):1865-70.
113
67. Lange MC, Cabral NL, Moro CH, Longo AL, Gonçalves AR, Zétola VF, Rundek T.
Incidence and mortality of ischemic stroke subtypes in Joinville, Brazil: a population-based study. Arq Neuropsiquiatr. 2015;73(8):648-54.
68. Adeloye D (2014) An Estimate of the Incidence and Prevalence of Stroke in Africa: A Systematic Review and Meta-Analysis. PLOS ONE 9(6): e100724. doi:10.1371/
journal. pone.0100724
69. Osuntokun BO, Adeuja AO, Schoenberg BS, Bademosi O, Nottidge VA, Olumide AO et al. Neurological disorders in Nigerian Africans: a community based study. Acta Neurol Scand. 1987; 75:13–21.
70. Onwuchekwa A.C, Tobin-West C., Babatunde S., Prevalence and Risk Factors for Stroke in an Adult Population in a Rural Community in the Niger Delta, South-South Nigeria. J Stroke Cerebrovasc Dis. 2014 ;23(3):505-10.
71. Sanya E.O,Desalu O.O, Adepoju F., Aderibigbe S.A., Shittu A., Olaosebikan O.
Prevalence of stroke in three semi-urban communities in middle-belt region of Nigeria: a door to door survey. Pan African Medical Journal. 2015; 20:33
72. Danesi M, Okubadejo N, Ojini F. Prevalence of stroke in an urban, mixed-income community in Lagos, Nigeria. Neuroepidemiology. 2007; 28:216–223
73. Enwereji K.O Nwosu M.C. Ogunniyi A, Nwani P.O., Asomugh A.L. , Enwereji E.E Epidemiology of stroke in a rural community in southeastern Nigeria Vascular Health and Risk Management 2014:10 375.
74. Connor M, Bryer S. Stroke in South Africa. Chronic diseases of lifestyle South Africa 1995-2005
75. Pandian JD, Singh G, Kaur P, Bansal R, Paul BS, Singla M .Incidence, short-term outcome, and spatial distribution of stroke patients in Ludhiana, India.,. Neurology.
2016 2;86(5):425-33.
114
76. Ogun SA. Acute stroke mortality at Lagos University Teaching Hospital—a five-year review. Nig Q J Hosp Med. 2004;10:8–10.
77. Obiako OR, Oparah SK, Ogunniyi A. Prognosis and outcome of acute stroke in the University College Hospital Ibadan, Nigeria. Niger J Clin Pract 2011; 14(3): 359–362.
78. Lekoubou A, Nkoke C, Dzudie A, Kengne AP. Stroke admission and case-fatality in an urban medical unit in sub-Saharan Africa: a fourteen-year trend study from 1999 to 2012. J Neurol Sci. 2015;15;350(1-2.
79. Fawi G.H, Corea F,Abbas M.A., Thabit M.N., Comi G. Southern Egypt Stroke Study:
Case Fatality Rates in a Hospital-Based Setting . The Open General & Internal Medicine Journal 06/2009; 3(1):40-46.
80. Janes F1, Gigli GL, D'Anna L, Cancelli I, Perelli A, Canal G, et al.Stroke incidence and 30-day and six-month case fatality rates in Udine, Italy: a population-based prospective study. int J Stroke. 2013 ;8 Suppl A100:100-5.
81. O'Donnell MJ, Xavier D, Liu L, Zhang H, Chin SL, Rao-Melacini P, Rangarajan S.
Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. (Lancet. 2010 , 10;376(9735):112-23.
82. WHO STEPS Stroke manual: the WHO STEPwise approach to stroke surveillance.
Geneva: World Health Organization, 2006.
83. Arjundas D, Pandiyan U, Arjundas G, Baux H. Surveillance of stroke: WHO STEP-wise approach: A Chennai stroke Unit report. Ann Indian Acad Neurol 2007; 10: 154-9.
84. Brown RD, Whisnant JP, Sicks RD, O’Fallon WM, Wiebers DO. Stroke incidence, prevalence, and survival: secular trends in Rochester, Minnesota, through 1989.
Stroke. 1996; 27:373-380.
115
85. Lewsey JD1, Gillies M, Jhund PS, Chalmers JW, Redpath A, Briggs A et al. Sex differences in incidence, mortality, and survival in individuals with stroke in Scotland, 1986 to 2005. Stroke. 2009 (4):1038-43.
86. Howard G, Anderson R, Sorlie P, Andrews V, Backlund E, Burke GL. Ethnic differences in stroke mortality between non-Hispanic whites, Hispanic whites, and blacks: The National Longitudinal Mortality Study. Stroke. 1994; 25:2120-2125.) 87. Boden-Ablala B, Gu Q, Kargman DE, Lipset C, Shea S, Hauser WA, Paik M, Sacco
RL. Increased stroke incidence in Blacks and Hispanics: The Northern Manhattan Stroke Study. Neurology. 1995;45(suppl 4) A300.
88. Welin L, Svärdsudd K, Wilhelmsen L, Larsson B, Tibblin G. Analysis of risk factors for stroke in a cohort of men born in 1913. N Engl J Med. 1987 27;317(9):521-6.
89. Kiely DK1, Wolf PA, Cupples LA, Beiser AS, Myers RH. Familial aggregation of stroke. The Framingham Study. Stroke. 1993 ;24(9):1366-71
90. Martini SR, Flaherty ML, Brown WM, Haverbusch M, Comeau ME, Sauerbeck LR et al Risk factors for intracerebral hemorrhage differ according to hemorrhage location.
Neurology. 2012 4;79(23):2275-82.
91. MacMahon S, Rodgers A. The epidemiological association between blood pressure and stroke: implications for primary and secondary prevention. Hypertens Res.
1994;17(suppl 1): S23-S32.
92. SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA. 1991; 265:3255-3264.
93. Ekeh B.C, AO Ogunniyi A.O, Isamade E.I. . Stroke Risk Factors among Patients in a Nigerian Teaching Hospital. Journal of Medicine in the Tropics.Vol 15 No 1(20
116
94. Byington RP, Jukema JW, Salonen JT, Pitt B, Bruschke AV. et al Reduction in cardiovascular events during pravastatin therapy: pooled analysis of clinical events of the Pravastatin Atherosclerosis Intervention Program. Circulation. 1995; 92:2419-2425.
95. Ogunrin OA, Unuigbe E.Serum lipids in patients with stroke--a cross-sectional case-control study. J Natl Med Assoc. 2008 Sep;100(9):986-90.
96. Shinton R, Beevers G. Meta-analysis of relation between cigarette smoking and stroke.
BMJ. 1989; 298:789-794.
97. Wolf PA, D’Agostino RB, Kannel WB, Bonita R, Belanger AJ. Cigarette smoking as a risk factor for stroke: The Framingham Study. JAMA. 1988; 259:1025-1029.
98. Kawachi I, Colditz GA, Stampfer MJ, Willett WC, Manson JE, Rosner B, et al.
Smoking cessation and decreased risk of stroke in women. JAMA. 1993; 269:232-236.
99. Reynolds K1, Lewis B, Nolen JD, Kinney GL, Sathya B, He J.Alcohol consumption and risk of stroke: a meta-analysis. JAMA. 2003 5;289(5):579-88
100. Gill JS, Shipley MJ, Tsementzis SA, Hornby RS, Gill SK, Hitchcock ER,et al Alcohol consumption--a risk factor for hemorrhagic and non-hemorrhagic stroke. Am J Med.
1991 ;90(4):489-97.
101. Abbott RD, Rodriguez BL, Burchfiel CM, Curb JD. Physical activity in older middle-aged men and reduced risk of stroke: The Honolulu Heart Program. Am J Epidemiol.
1994; 139:881-893.
102. Kiely DK, Wolf PA, Cupples LA, Beiser AS, Kannel WB. Physical activity and stroke risk: The Framingham Study. Am J Epidemiol. 1994; 140:608-620.
103. Doménech M, Roman P, Lapetra J, García de la Corte FJ, Sala-Vila A et al.
Mediterranean diet reduces 24-hour ambulatory blood pressure, blood glucose, and lipids: one-year randomized, clinical trial. Hypertension. 2014 ;64(1):69-76.
117
104. Guasch-Ferré M, Hu FB, Martínez-González MA, Fitó M, Bulló M, Estruch R et al.
Olive oil intake and risk of cardiovascular disease and mortality in the PREDIMED Study. BMC Med. 2014 13;12(1):78. doi: 10.1186/1741-7015-12-78.
105. Tsivgoulis G, Psaltopoulou T, Wadley VG, Alexandrov AV, Howard G, Unverzagt FW et al Adherence to a Mediterranean diet and prediction of incident stroke. Stroke.
2015 46(3):780-5.
106. Wilhelmsen L, Svardsudd K, Korsan-Bengtsen K, Larsson B, Welin L, Tibblin G.
Fibrinogen as a risk factor for stroke and myocardial infarction. N Engl J Med. 1984;
311:501-505.
107. Kannel WB, Wolf PA, Castelli WP, D’Agostino RB. Fibrinogen and risk of cardiovascular disease: The Framingham Study. JAMA. 1987; 258:1183-1186.
108. Perry IJ, Refsum H, Morris RW, Ebrahim SB, Ueland PM, Shaper AG. Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. Lancet. 1995; 346:1395-1398.
109. Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: The Framingham Study. Stroke. 1991 ;22(8):983-8.
110. Barletta GA, Gagliardi R, Benvenuti L, Fantini F. Cerebral ischemic attacks as a complication of aortic and mitral valve prolapse. Stroke. 1985 ;16(2):219-23.
111. Benjamin EJ, Levy D, Vaziri SM, D’Agostino RB, Belanger AJ, Wolf PA.
Independent risk factors for atrial fibrillation in a population-based cohort: The Framingham Heart Study. JAMA. 1994; 271:840-844.
112. Weimar C, König IR, Kraywinkel K, Ziegler A, Diener HC. Age and National Institutes of Health Stroke Scale Score within 6 hours after onset are accurate predictors of outcome after cerebral ischemia: development and external validation of prognostic models German Stroke Study Collaboration. Stroke. 2004;35(1):158.,5
118
113. Desilles JP, Meseguer E, Labreuche J, Lapergue B, Sirimarco G, et al J,Diabetes mellitus, admission glucose, and outcomes after stroke thrombolysis: a registry and systematic review. Stroke. 2013 44(7):1915-23. Epub 2013 May 23.)
114. Saini M1, Saqqur M, Kamruzzaman A, Lees KR, Shuaib A; VISTA Investigators.
Effect of hyperthermia on prognosis after acute ischemic stroke Stroke. 2009 40(9):3051-9
115. Burneoj.G, Fang J. and Saposnik G, For Investigators of the Registry Of The Canadian Impact Of Seizures On Morbidity And Mortality After Stroke: A Canadian Multicenter Cohort Study. European Journal of Neurology 2010, 17:52-58.
116. Cucchiara BL, Kasner SE , Wolk Da, Lyden P.D., Knappertz VA, Ashwood T et al , class-1 investigators . Early Impairment In Consciousness Predicts Mortality After Hemispheric Ischemic Stroke. Crit Care Med. 2004; 32(1):241-5.
117. Weir CJ , Bradford PJ and Lees KR. The prognostic value of components of the Glasgow Coma Scale Following Acute Stroke. Oxford Journals Medicine: An International Journal Of Medicine 2003; 96, issue 1Pp. 67-74.
118. Adams HP Jr, Davis PH, Leira EC, Chang KC, Bendixen BH, Clarke WR, et al Baseline NIH Stroke Scale score strongly predicts outcome after stroke: A report of the Trial of Org 10172 in Acute Stroke Treatment (TOAST). Neurology. 1999 13;53(1):126-31).
119. Frankel MR, Morgenstern LB, Kwiatkowski T, Lu M, Tilley BC, Broderick JP, et al Predicting prognosis after stroke: a placebo group analysis from the National Institute of Neurological Disorders and Stroke rt-PA Stroke Trial. Neurology. 2000 10;55(7):952)
120. Dawodu C.O. & Olaniyan A.K. The Predictive Value of the National Institute of Health. 1.Stroke Scale (NIHSS) For Haemmorhagic Stroke 1. Patients in a Non –
119
Interventional StudyOnline Journal of Medicine and Medical Science Research.
Volume 1, Issue 3, pp. 42-48; June 2012
121. Baird AE, Dambrosia J, Janket S, Eichbaum Q, Chaves C, Silver B, et al, A three-item scale for the early prediction of stroke recovery. Lancet. 2001; 30;357(9274):2095-9.
122. Vogt G, Laage R, Shuaib A, Schneider A; VISTA Collaboration.Initial lesion volume is an independent predictor of clinical stroke outcome at day 90: an analysis of the Virtual International Stroke Trials Archive (VISTA) database. Stroke. 2012
;43(5):1266-72.
123. Abboud H, Berroir S, Labreuche J, Orjuela K, Amarenco P; GENIC Investigators.
Insular involvement in brain infarction increases risk for cardiac arrhythmia and death.
Ann Neurol. 2006 A;59(4):691-9. PMID: 16566012,
124. Kaarisalo MM, Immonen-Räihä P, Marttila RJ, Salomaa V, Kaarsalo E, Salmi K et al Atrial fibrillation and stroke. Mortality and causes of death after the first acute ischemic stroke. Stroke. 1997 ;28(2):311-5
125. Jia Q, Zhao X, Wang C, Wang Y, Yan Y, Li H, et al Diabetes and poor outcomes within 6 months after acute ischemic stroke: The China National Stroke Registry.
Stroke. 2011 ;42(10):2758-62.
126. Brammås A, Jakobsson S, Ulvenstam A, Mooe T. Mortality after ischemic stroke in patients with acute myocardial infarction: predictors and trends over time in Sweden.
Stroke 2013; 44:3050)
127. Tanne D, Molshatzki N, Merzeliak O, Tsabari R, Toashi M, Schwammenthal Y.
Anemia status, hemoglobin concentration and outcome after acute stroke: a cohort study. BMC Neurol. 2010; 10: 22.