FORMULATION AND EVALUATION OF TELMISARTAN FAST DISSOLVING TABLETS BY DIRECT COMPRESSION METHOD

Debjit Bhowmik*, Rishab Bhanot ,K.P.Sampath Kumar

Himachal Institute of Pharmaceutical Education and Research , Nadaun, Hamirpur, H.P. Department of Pharmacy, Coimbatore government medical college, Coimbatore

ABSTRACT Telmisartan is a ACE inhibitor anti-hypertensive drug. Hence, in the present work, Telmisartan fast dissolving tablets will be prepared by using different superdisintegrating agents. The amount of drug that is subject to first pass metabolism is reduced as compared to mouth dissolving tablets. Orally disintegration tablets contain wide variety of pharmaceutical active ingredients covering many therapeutic categories. The time for disintegration of orally disintegrating tablets are generally considered less than one minute. Orally disintegrating tablets are characterized by high porosity, low density and low hardness. The blend was examined for the pre-compressional parameters and post-compression parameters. Drug compatibility with excipients was checked by FTIR studies. The values of pre- compression parameters evaluated were within prescribed limits and indicated good free flowing property. In all the formulations, friability is less than 1%, indicated that tablets had a good mechanical resistance. Drug content was found to be in the range of 98 to 102%, which is within acceptable limits. Hardness of

the tablets was found to be in the range of 3-4 Kp. The in vitro dispersion time was found to be in the

excipients was confirmed by FTIR studies. The drug release from tablets of Telmisartan prepared by direct compression showed that 98.20% drug release within 15 minute.

HIPER/P/15

Chitosan Nanoparticles: A Gifted System for Drug Delivery

Riya*,Abhishek Modgil, Sahil Dhillon, Muskan Jaswal, Ayushi, Nitin Bhatia

DDM College of Pharmacy

ABSTRACT: For the past few decades, there has been a considerable research interest in the area of drug delivery using particulate delivery system as carrier for small and large molecules. Particulate systems like nanoparticles have been used as physical approach to alter and improve the pharmacokinetic & pharmacodynamic properties of various types of drug molecules. Nanoparticles are solid colloidal particles with diameter ranging from 1-1000nm. Polymeric nanoparticles possess better reproducibility & stability profiles. Now various polymers have been used in formulation of nanoparticles for drug delivery to increase therapeutic benefit. Chitosan is the modified natural carbohydrate polymer. Chitosan nanoparticles have gained more attention as drug delivery carrier because of low toxicity, simple & mild preparation method and versatile route of administration. There sub-micron size not only suitable for parenteral application, but also applicable for mucosal routes of administration. Chitosan exhibits number of ideal properties for nanoparticles preparation & it also possess properties of polymer carrier for nanoparticles such as biocompatible, biodegradable & inexpensive. Chitosan also provides absorption promoting effect that prolongs the contact time between substrate & cell membrane. Due to its unique nature, it gains more attention as drug delivery carrier.

HIPER/P/16

Conventional Therapeutic Approaches In Visual Infection By Stem Cell Therapy Vishal Jaggi*1, Dinesh Tabyal1, Vikas1, Pratibha1, Tarun Sharma1, Ravinder Khatri2

DDM College of Pharmacy1

Lord Shiva College of Pharmacy2

ABSTRACT: From the past two decades ocular microbial infection has emerged as a main community health disaster. An assortment of contributory agents can cause ocular microbial infections; which are characterized by persistent and destructive inflammation of the ocular tissue; progressive visual disturbance; and may result in loss of visual function in patients if early diagnosis does not received. The conservative remedial approaches to cure the vision impairment and sightlessness ensuing from microbial infections involve antimicrobial therapy to eliminate the felonious pathogens from the infected area. Despite advances in medical research; progress in the control of ocular microbial infections remains slow. The varying level of ocular tissue recovery in individuals and the incomplete visual functional restoration indicate the chief limitations of current strategies. The development of a more extensive therapy is needed

to help in healing to regain vision in patients. Stem cells are multipotent stromal cells that can give rise to a enormous variety of cell types following proper differentiation protocol. Stem cell therapy shows pledge in plummeting inflammation and repairing tissue damage on the eye caused by microbial infections by its ability to transform immune response and promote tissue regeneration. This article reviews a selected list of common infectious agents affecting the eye; which include fungi; viruses; parasites and bacteria with the aim of discussing the current antimicrobial treatments and the associated therapeutic challenges.

HIPER/P/17

Use of Nanotechnology in Cosmetic Dermatology

Preeti*1, Lakhwinder1, Varun Kumar1, Lovely Kumar1, Namrata1, Ravinder Khatri2

DDM College of Pharmacy1

Lord Shiva College of Pharmacy2

ABSTRACT: Nanotechnology is the science of manipulating atoms and molecules in the nanoscale - 80,000 times smaller than the width of a human hair. The use of nanotechnology has stretched across various streams of science, from electronics to medicine and has now found applications in the field of cosmetics by taking the name of nanocosmetics. This widespread influence of nanotechnology in the cosmetic industries is due to the enhanced properties attained by the particles at the nano level including color, transparency, solubility etc. The different types of nanomaterials employed in cosmetics include nanosomes, liposomes, fullerenes, solid lipid nanoparticles etc.Cosmetic dermatology, recognizing the new realities of skin care products, has to emphasize the functional aspects of cosmetics through an understanding of their efficacy and safety in promoting good health.Developments in nanotechnology will provide opportunities for cosmetic dermatology to develop new biocompatible and biodegradable therapeutics, delivery systems and more active compounds.Nanoscience may help the scientific community to find more innovative and efficacious cosmetics. Understanding the physical model of the cell as a machine is essential to understand how all the cell components work together to accomplish a task. The efficacy and safety of new nanomaterials has to be deeply studied by ex vivo tests and innovative laboratory techniques. New delivery systems and natural nanocompounds, such as chitin nanofibrils for wound healing, are being used in cosmetic dermatology with good results, as are nanostructured TiO2 and ZnO sunscreens.

HIPER/P/18

Formulation and Evaluation of Fast Dissolving Tablets of Valsartan using Combination of Natural and Synthetic Superdisintegrants

Priya*, Namrata, RekhaRana, Kajal, Deeksha Sharma

ABSTRACT: Valsartan is used to treat high blood pressure and congestive heart failure. It is Angiotensin II receptor antagonist.In the present study, fast disintegrating tablets of Valsartan were formulated by using direct compression employing the use of superdisintegrants to achieve the rapid disintegration property and enhanced bioavailability. Superdisintegrants were used by two means i.e. i)Direct addition ofsuperdisintegrants (SSG, Crospovidone, Croscarmellose sodium and isabgol) in different concentrations (3,6,9 and 12 %), ii)Physical mixtures of superdisintegrants in different ratios (from 3 % of sodium starch glycolate, crospovidone, Croscarmellose with 3 % isabgol respectively and from 6 % of sodium starch glycolate, crospovidone, Croscarmellose with 6 % isabgol respectively).The effectof superdisintegrants on wetting time, disintegrating time, in vitro drug releasehas been studied. The prepared tablets were characterized by DSC and FTIR studies. Nochemical interaction between drug and excipient was confirmed.The values of pre-compression parameters evaluated were within prescribed values and indicated good free flowing property. The prepared tablet formulations were evaluated for post- compression parameters and results were within IP acceptable limits.The disintegration time of tablets was found to be between 11.54-28.96 s. The wetting time of tablets was found to be between 14.42-38.16 s.The drug content of all the formulations varied between 98.76-100.65 % .The release data obtained were subjected for the kinetic treatment to know the type and order of drug release.The good relationship was evidenced in the Hixon-Crowell‘s Cube Root Law which signifies the drug was assumed to dissolve out from the matrix or from the surface of the device. Physical mixture of superdisintegrants containing synthetic (Croscarmellose sodium) and natural (Isabgol) was found to be more effective in preparation of fast disintegrating tablets. Disintegration time and Dissolution rate was found to be faster in the tablets containing mixture of superdisintegrants as compared to tablets containing individual superdisintegrants in same ratios.Also the formulation prepared using Synthetic and natural mixtures having higher concentration of Isabgol and Croscarmellose sodium have shown faster disintegration and resulted in higher dissolution compared to formulation containing higher concentration of sodium starch glycolate. This implied that Physical mixture of natural and synthetic superdisintegrant can be used as a better disintegrant compared to individual.

HIPER/P/19

Natural resources and their scopes in North Bengal a part of Sub Himalayan region U Sharma1*, S Das 2,

The West Bengal University of Health Sciences, Kolkata, W.B., India Calcutta Medical College and Hospital, Kolkata, W.B., India

ABSTRACT: Medicinal plants have an incredible part in home solutions for enhance wellbeing condition and one next to the other in National Economy. Natural herbs based Nutraceuticals and Cosmeceuticals Industries are building up a promising part with colossal economy development potential in India. In Himalayan region we have more than 3,169 dicotyledon and 1,000 monocotyledon normal species. In North Bengal, which is a piece of Sub-Himalayan part, where more than 100 high demanded restorative

plants can be developed relying upon most cute climatic condition and Industrial request. There are such a large number of medicinal plants which have ethno therapeutic uses and logical uses which require investigating to the world to profit the individuals to beat their regular diseases.

HIPER/P/20

Diabetes Mellitus and its Herbal Treatment- Our Experience based Review Amit Kumar Dutta* , Mrs. Arpita Mukherjee**

* School of Biological & Chemical Sciences, MATS University, Raipur (CG)- 492002(India).

** Department of Biotechnology, Rungta College of Science & Technology, Durg(CG).

ABSTRACT: Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar (glucose) levels that result from defects in insulin secretion, or action, or both. Diabetes mellitus, commonly referred to as diabetes was first identified as a disease associated with "sweet urine," and excessive muscle loss in the ancient world. Elevated levels of blood glucose (hyperglycemia) lead to spillage of glucose into the urine, hence the term sweet urine. Normally, blood glucose levels are tightly controlled by insulin, a hormone produced by the pancreas. Insulin lowers the blood glucose level. When the blood glucose elevates (for example, after eating food), insulin is released from the pancreas to normalize the glucose level. In patients with diabetes, the absence or insufficient production of insulin causes hyperglycemia. Diabetes is a chronic medical condition, meaning that although it can be controlled, it lasts a lifetime. Herbal medicines have been highly esteemed source of medicine throughout the human history. They are widely used today indicating that herbs are a growing part of modern high-tech medicine. Some of the herbal plants and active chemical constituents which have a role in the management of Diabetes mellitus are compiled here are discussed in this review.

HIPER/P/21

Role of Nanoparticles in Plants

Amit Kumar *, Mufida Fayaz, Musadiq Hussain Bhat and Ashok K. Jain

School of Studies in Botany, Jiwaji University, Gwalior

ABSTRACT: Nanotechnology opens a large scope of novel application in the fields of biotechnology and agricultural industries, because nanoparticles (NPs) have unique physicochemical properties, i.e., high surface area, high reactivity, tunable pore size, and particle morphology. Nanomaterials and nanotechnology have been widely applied in the world in this last decade. Nanotechnology provides the tool and the technological platforms for the study and transformation of biological systems. Few studies have focused on the effects and mechanisms of nanomaterials on plants. Therefore, the present review highlights the key role of nanoparticles in plants. Moreover, nanoscience contributes new ideas leading us to understand the suitable mode of action of nanoparticles in plants.

HIPER/P/22

ROLE OF NANOTECHNOLOGY IN DRUG DELEVERY