Cumulative Subject Index Volume 1 to Volume 15
4:90, 107 high-throughput
drug testing 14:405
high-throughput analysis 3:491, 12:104 high-throughput genomics approaches
14:156–157
high-throughput genotyping 7:180 high-throughput protein production 2:460 high-throughput screening (HTS) 3:600,
4:492f, 8:90, 94, 11:616, 622, 625 hindbrain specification 2:99–103 HindII 12:325
hindsight (HNT) 4:292ff HINT domain 11:242 hippocampus 11:251, 13:410ff hippuric acid 1:429
HIS3 11:61
Hispanic Americans
frequent HLA-Cw/B blocks 13:199 his-tag 4:362
histamine 14:48 histamine H3
antagonists 10:208 receptor 10:208
histidine kinases 8:297ff, 298, 310, 335, 337 histidine operon 12:33
histidine protein kinases 8:293, 308, 335 histidine tag 11:348
histocompatibility markers 13:337 histogram matching 7:444 histologies
non-SCLC 5:355 SCLC 5:355
histone acetylase (HAT1, Hbo1) 12:193 histone acetylation 4:248, 5:480, 15:14 histone acetyltransferase (HAT) 3:470, 9:519 histone deacetylase (HDAC) 9:519, 10:131,
12:156ff, 193ff, 14:268, 15:18
histone deacetylase inhibitors (HDAC Is) 4:268, 15:14
histone H3 14:237ff histone H4 6:11
histone methylation 4:251, 5:480 histone methyltransferase (HMT) 12:156 histone modifications 10:131
ATP-dependent chromatin remodeling machines 2:419
fluid properties 2:420
heterochromatin proteins 2:419 histone acetylation 2:418 histone phosphorylation 4:254
histones 7:505, 12:101, 14:3, 255, 268, 15:13ff biotinylation of 15:529–530
HIV antigen 15:147 HIV entry inhibitors 6:168
HIV (human immunodeficiency virus) 1:377, 4:205, 6:389, 555, 559, 608, 8:454, 11:122, 12:411
drug therapy of 1:114–115 immune response to 1:112–114 life cycle of 1:103–108
molecular biology of 1:102–110 natural selection 6:329 origins of 1:100–102 virus structure of 1:102–103
HIV protease 2:606, 8:98, 101, 13:549, 565, 577ff
flexibility 13:582
inhibitor complexes 13:579 HIV reverse transcriptase 10:200ff HIV therapeutics 6:155–171
HIV-1 genome 15:241
HIV-1 (human immunodeficiency virus 1) 1:391, 3:88, 90, 91, 93, 12:402, 404, 410, 13:258, 15:148
HIV-1 nucleocapsid protein 6:171 HIV-1 replication 15:418 HIV-1 RNA genome 15:140 HLA alleles
DNA methods 13:196 HLA blocks 13:198
HLA class IIDQ and DR alleles 6:15 HLA haplotypes
allelic variants 13:207 nonrandom association 13:207 HLA polymorphism 13:193 HLA restrictions 15:164 HLA segregation
specific parental haplotypes 13:207 HLA-A
allele-level typing of 13:209 HLA-Cw 13:211
HLA-Cw/B block 13:198 extension of 13:203 HLA-DM 1:385, 395
molecular chaperone 1:371 peptide editor 1:371 peptide loading 1:371 x-ray analysis 1:370 HLA-DO 1:385
CLIP removal 1:386 cochaperone 1:386
HLA-DM–HLA-DO complexes 1:386 lysosomal MIICs 1:386
HLA-DQB1 13:211 HLA-DR/DQ block
HLA-DPB1 13:203
HLA-DRB1, -DQB1 haplotypes 13:199 HLA-G 6:485–486
HL-60 cells GM3 5:561
neolacto-series gangliosides 5:561 Hlx 6:203
H2-M 1:370 HM74 14:686 HMBC 13:531
HMG-CoA reductase 7:198, 217, 218 HMG-CoA synthase 7:198, 217, 218 HMLH1
cancer 1:82 hMLH1 6:11, 15, 21, 24 HMM 9:255, 256, 263 HMQC-NOESY 13:572 hMSH2 6:15, 21
HMW genomic DNA 3:408
[3H]NaBH4 5:540 HNF1α 6:185ff HNF4-α 7:220 HNF 6:207ff HnRNA 12:24 H-NS 3:541
HO endonuclease 8:320
Hoechst 33:258 13:562, 565, 566, 569 HOKPP 11:673
hok/sok system 10:430 holism 14:125
holistic experiments 8:204
Holliday junction-RuvA complexes 9:309 Holliday junctions 3:545, 9:308ff
BLM 1:74 WRN 1:74 hollow fiber 7:547 holocentric 9:54, 60 holoenzyme 9:572, 583 holographic memories 9:560 holokinetic 9:54, 60
holoprosencephaly (HPE) 15:48ff holorepressors 3:513
homeobox 6:181ff
homeobox gene 6:189ff, 14:267, 15:182, 187 sine oculis (SO) 6:189
homeodomain 2:100, 6:181ff, 186ff, 15:49ff class 6:187
family 6:187 superclass 6:187
homeodomain protein 13:298
homeodomain-containing proteins 9:472 homeostasis 6:385, 399, 8:212, 448, 449, 531,
536ff, 11:597, 14:130, 132 homeotic gene 6:181ff, 190ff homeotic selector 13:301 homeotic selector genes 13:273ff homing endonucleases 11:242, 243, 247
intein homing 11:250 LAGLI-DAG 11:250 hominoids 2:553ff homo sapiens 10:542, 548 homochiral 10:18 homocysteine 8:226 homodimer 5:642, 6:186ff homodimeric ENase 12:327 homoduplex 9:311ff homogeneous assays 4:493
homogeneous transformation matrix 12:619 homologous 3:117, 5:314
homologous chromosomes 1:77
homologous recombination 1:217, 219, 5:175, 297, 7:316, 12:3ff, 14:521
break-induced replication 12:7
D-loop 12:7 DNA ligase 12:11 DNA repair 11:528
double-strand break repair 12:5 endonuclease 12:11
gene conversion 12:4 gene disruption by 3:340–341 Holliday junctions 12:5 insert foreign DNA 13:395
insertion of reporter molecule 13:395 nonreciprocal recombination 12:4 Rad52 12:11
reciprocal recombination 12:3 RPA protein 12:11
single-strand annealing 12:8 steps in 11:529
synthesis-dependent strand annealing 12:7
transformation 12:5
homologous recombination gene targeting 1:214
homologous recombinational repair (HRR) 1:56, 73ff, 77
ATM 1:82 ATR 1:82 BRCA1 1:82 BRCA2 1:82 conjugation 1:69 FANCD2 1:82 HMLH1 1:82 p53 1:82 Rad51 1:82
self-fertilization 1:69 sexual reproduction 1:69
homologous signal transduction pathways 3:271
homologs 3:141, 14:3 homology 11:213, 225, 227
analogs 11:218
ancestral sequence 11:210 common ancestor 11:211
common evolutionary ancestor 11:208 convergent evolution 11:208
evolutionary relationship 11:205, 210 families 11:205
fold 11:211
four-helical cytokine superfamily 11:205 homologous proteins 11:204
inference 11:211 modeling 11:134
nonorthologous displacement 11:218 phylogenetic profile 11:217
phylogenetic relationships 11:205 protein classification
families 11:208
superfamilies 11:205, 208, 211, 213 protein evolution 11:205
searching 5:532
sequence similarities 11:204ff, 210 structural similarity 11:205 superfamilies
xenologs 11:218, 220 homolysis 6:35
homothorax (hth) 6:214ff homotypic fusion 4:195 homozygous 11:657, 14:509 homozygous mutation 9:311 homunculus 13:332 hook 8:397 hopping 12:331
intersegment transfer 3:538 horizontal (dark) basal cell 12:643 horizontal gene transfer 5:337, 343, 344,
6:225, 10:436, 11:218f horizontal spread 10:436 horizontal transfer 10:412
hormonal replacement therapy 3:318 hormone 4:161, 5:638, 640, 8:436, 450, 13:8,
145ff
androgen 7:509 disease 4:174 estrogen 7:512 FSH 7:503 NT3 7:503 nuclear 7:107 receptors family 7:107 retinoic acid 7:503 testosterone 7:512
thyroid hormone 7:505, 513
hormone binding domains (HBD) 1:448 conformation of 1:441–442
structure of 1:441–442
hormone response elements (HREs) 15:510 hormone-sensitive lipase (HSL) 1:5, 14:627ff horseradish peroxide (HRP) 6:40, 8:214 horsetail 14:232ff
homologous chromosomes 14:232 homologous recombination 14:232 host immune response
antibodies 1:566 complement 1:566 evasion 1:566
serum resistance 1:566 host–pathogen interactions 13:320 host preference 7:485
host range 15:241 host resistance 10:373 host systems 3:395ff
host–vector system 2:41 hotspots 13:192, 208
hypothetical chromosomal regions 13:193
hot-start 11:487ff
housekeeping genes 11:516ff HOX 10:542, 15:48
HOX cluster 6:181ff, 13:302 Hox family 2:228
Hox genes 6:181ff, 12:160, 15:188 HOX homeotic gene family 14:252ff HoxA9 2:232
HP1 14:237 HP1HSα 1:492 HP1HSβ 1:492 HP1HSγ 1:492 HPAEC
carbohydrate analysis 2:256, 257 hpg mouse 4:407
HPLC, see high performance liquid chromatography
hPot1 14:236
HPV, see human papillomavirus HR genes
BRCA1 12:10 Rad54 12:10 Rad51 paralogs 12:10 hRap1 14:232ff HSA 13:587
diflusinal brady 13:588 HSC
hierarchy of the hematopoietic system 2:227
targets for malignant transformation 2:232
HslO 2:510
HslU–HslV 13:508–509 Hsp10 2:494
Hsp15 13:506
Hsp33 2:510, 13:505–506 Hsp40 2:501
Hsp47 2:514ff Hsp60 2:494 hsp60 6:14
Hsp70 1:35, 2:501ff, 511ff, 13:497–498 Hsp90 1:35, 2:172, 180, 504, 511, 13:503–504
regulation of 2:180–182 structure of 13:497–499 Hsp100 1:35
Hsp104 2:502
HSP (heat shock protein) 1:390, 393, 394, 620, 6:14, 8:450, 531, 535ff, 10:92, 15:10ff stress-induced expression of 13:463–512 Hsp70 system 13:492–500
HSQC 13:518, 525, 526, 530, 555, 583, 587, 589, 598
chemical-shift mapping 13:561 HSR 3:46
hst-1 and int-2 genes 6:5 HSV, see herpes simplex virus HSV-TK 15:266
[3H]thymidine 13:412ff HTLV 8:454
HtrA proteases 13:509 HtrA2/Omi 10:623, 625 5HT3receptor 11:564 hTRF1 14:231ff hTRF2 14:231ff
HTS, see high-throughput screening HU 3:541
Hugh and Leifson’s method 1:519 HuIFN-α2 15:393
HuIFN-γ 15:401 HuIFN-ß 15:401 HuIFN-α subtypes 15:401 human f
porin 31HL 8:372f VDAC1/porin1 8:372f human annulus
modeling of 14:400
human antichimeric antibody (HACA) 1:337 human antimouse antibody (HAMA) 1:335,
10:224
human bacterial diseases anthrax 6:304 cholera 6:304
enterotoxigenic Escherichia coli 6:305 plague 6:306
shigellosis 6:306 tuberculosis 6:307 tularemia 6:309 typhoid fever 6:308 whooping cough 6:309 human blastocysts 13:387 human blood group
A 2:282 B 2:282 dextrans 2:283 diheteroglycans 2:283 H 2:282
triheteroglycans 2:283 human blood plasma 7:166 human cancer gene 7:118 human–chimpanzee comparison
biomedical differences 2:570ff cytogenetic differences 2:561 DNA sequence differences 2:575 ethical considerations 2:572
human rights 2:572ff infectious diseases 2:571 qualitative difference 2:572 human conception fail
natural meiosis-based 1:86
spontaneous and induced abortions 1:86 human diseases
genetic defects in 12:690 smell dysfunction in 12:690–695 human EGF 5:643
human embryonic stem cells (hESC) 13:401, 403
human factor IX (hFIX) 15:292 human gene therapy 12:410 human genetic disease 6:323–333 human genetic diversity 13:193 human genetic information 14:6
human genetic variation 6:323–325, 329–333 mutation 6:326–328
natural selection
heterozygote advantage 6:328–329 sickle cell disease 6:328–329
human genome 4:331, 6:572, 10:548, 11:596, 13:194
body expression map of 2:75–83 body-map data 2:79
computational methods of 2:80–82 MHC loci 13:207
overview of 2:77–79
human genome project (HGP) 2:77, 8:266, 13:77
BAC (bacterium artificial chromosome)-based STS (sequence-tagged site) 13:75, 78 cosmids 13:78
gene transfer vehicles 15:491 genome-scale physical mapping effort
13:78
large-insert clones 13:78 minimal tiling path (MTP) 13:75 physical mapping 13:75
YAC (yeast artificial chromosome)-based 13:75
human growth hormone 10:586 human HepG2 cell 13:695 human (Hu) prions 10:563 human identity 3:492
human immunodeficiency virus, see HIV human immunodeficiency virus/acquired
immunodeficiency syndrome 15:136, see also HIV
human IVF 6:540
human leukocyte antigen (HLA) 6:516 human lung fibroblast cells 13:695 human MHC CEHs 13:192
human monoclonal antibodies in mice 1:337–338
human motor neuron diseases 8:542–543 human papillomavirus (HPV) 3:228, 6:555,
559, 12:185
human pathologies 8:134 human plasma 2:37
human PrP gene polymorphisms 10:585–586 human serum albumin, see HSA
human studies 5:358
human telomerase reverse transcriptase (hTERT) 2:201
human telomerase RNA 9:322 human therapeutics 7:305ff
human transcriptome map (HTM) 5:79 human trials 15:142
humanized antibodies 1:337 humidity control
crystal quality improvement 7:412 free mounting system
cryo-loop 7:413 humidifier unit 7:413 patch-clamp pipette 7:413
humoral effector mechanisms 6:422–427 humoral immunity 1:461, 10:86, 12:309–310 huntingtin 15:12
Huntington 4:332
Huntington’s disease (HD) 7:607, 10:260, 12:693, 15:6ff
inherited prion diseases 15:262 like 2ff 15:52
husbandry 1:222 hyaloid vessels 15:207 Hyalonema sieboldi 13:291 hyaluronidase 2:254 hybrid 9:334, 335 hybrid cell lines
radiation hybrids 5:456 hybrid organelle 4:206 hybrid proteasome 11:3, 5, 19 hybrid selection 3:45 hybrid simulation 14:141 hybrid state 12:505 hybrid state model 12:504 hybrid type 5:548ff, 579 hybrid vigor 1:84
hybridization 3:574, 6:226, 7:346, 478, 8:500, 9:334, 10:534, 14:255, 422, 426
hybrid-bridge 6:231, 234 hybridization assays 2:527 hybridization probes 11:498 hybridized DNA 14:431
hybridoma 1:331, 334, 472, 3:76, 77, 11:105 hydration 13:237–238
hydrazinolysis 5:540 hydrazone 11:64 hydrocarbons 10:9 hydrocephalus 9:120 hydrocephaly 12:163
hydrocephaly with hop gait 8:135 hydrodynamic stress 1:434 hydrogel 11:108, 14:386, 392 hydrogen 10:5
hydrogen bond 1:579, 4:504, 506, 10:204, 12:612, 615, 625, 626
hydrogen bonding 2:6ff, 9, 3:533, 13:524, 571, 573, 581
hydrogen bonding interactions 3:535 hydrogen out-of-plane 1:579, 581
hydrogen peroxide 5:494, 505, 8:210ff, 211, 217ff, 220, 221, 227, 231
hydrogen sulfide production, detection of 1:518
α/β-hydrolase 14:645 hydrolases 1:619 hydrolyze 10:18 hydronephrosis 3:312
hydrophobic effect 2:6ff, 10, 3:535
hydrophobic interaction chromatography (HIC) 6:248, 9:323
basic principles 6:260 mobile phase 6:262 stationary phase 6:261
hydrophobic interactions 1:29, 4:504, 509, 10:294
hydrops 9:232 hydrotalcite 10:11 hydrothermal 10:16
hydrothermal systems 10:7, 9 hydroxo complexes 1:643 α-hydroxy acid 11:55 hydroxy fatty acids 7:259
17β-hydroxyandrosta-1,4-dien-3-one 13:34 17β-hydroxy-5β-androstan-3-one 13:25 3β-hydroxy-5α-androstan-17-one 13:11 19-hydroxyandrostenedione 13:15 4-hydroxy-androstenedione 13:53, 55 hydroxyapatite (HTP) 8:361 6-hydroxydopa quinone 8:219 6-hydroxydopamine 4:643 17β-hydroxyestr-4-en-3-one 13:33 8-hydroxyguanine 4:638ff
hydroxyl radical 3:543, 4:522, 635ff, 5:494 hydroxylamine oxidoreductase (HAO) 6:63–64 hydroxylapatite 10:11, 19
17α-hydroxylase 13:9 hydroxylated products
benzo(a)pyrine 3:107
β-hydroxylation 6:116 hydroxylation 1:425, 6:56
17β-hydroxy-17α-methylandrostano[3,2-c]
pyrazole 13:39
2-hydroxymethylene-17α-methyl-5α-androstan-17β-ol-3-one 13:37
17β-hydroxy-17αmethyl-2-oxa-5α-androstan-3-one 13:37
11β-hydroxy-17α-methyltestosterone 13:36 4-hydroxy-17α-methyltestosterone 13:36 17α-hydroxypregnenolone 13:8 17αhydroxyprogesterone 13:8 3β-hydroxysteroid 13:10
17β-hydroxysteroid dehydrogenase 13:10 3β-hydroxysteroid dehydrogenase 13:56 11β-hydroxytestosterone 13:11 hyperactivity 4:590
hyperalgesia 10:30, 33 hyperammonemia 15:267 hyperbolic function 10:417
hyper-branched rolling circle amplification 7:189
hypercalcemia 3:314 hypercholesterolemia 4:212 hyperekplexia 11:682 hyperexcitability 11:672 hyperextensible joints 4:590 hyperfine splitting 4:119, 7:172 hyperglycemia
glycemic control 7:27
microvascular complications 7:45 hyperinsulinemia 14:635ff
hyperinsulinism in infancy (HI) 11:698 hyperkalemic periodic paralysis (HYPP)
11:672
hyperlipidemia 14:625