• No results found

For instance, Ui is independent o f factor inputs, or specific distributional specification of Ui

Model specification

11 For instance, Ui is independent o f factor inputs, or specific distributional specification of Ui

Ͳ129Ͳ

ComoconclusiónfinaldecirquedelestudiorealizadosedestacaqueelfactoreIF4E fosforiladoinduceunaclararesistenciaamúltiplessituacionesdeestréscelular,yendicho efectoesindispensablelauniónconelfactor4EͲT.Laformacióndelcomplejo,asícomoel estudiodeotrasproteínasymRNAsasociadostalescomoHuR,Ago2yotros,abrenlapuertaala deteccióndeproteínasymRNAsquepuedensertraducidosdeformamásselectivatras situacióndeestréscelularencélulasconsobreexpresióndelfactorfosforiladoeIF4E.

Porotroladoobservamosquelasobreexpresiónde4EͲTincrementalainvasiónylamigración celular,abriendounnuevocampodeestudioypudiendoserunanuevadianaterapéutica.

Ͳ130Ͳ

Ͳ131Ͳ

BIBLIOGRAFÍA

Ͳ132Ͳ

Ͳ133Ͳ

8.BIBLIOGRAFÍA

Adams,B.D.,K.P.Claffey,etal.(2009)."ArgonauteͲ2expressionisregulatedbyepidermal growthfactorreceptorandmitogenͲactivatedproteinkinasesignalingandcorrelates withatransformedphenotypeinbreastcancercells."Endocrinology150(1):14Ͳ23. Anderson,P.andN.Kedersha(2008)."Stressgranules:theTaoofRNAtriage."TrendsBiochem

Sci33(3):141Ͳ50.

Andrei,M.A.,D.Ingelfinger,etal.(2005)."AroleforeIF4EandeIF4EͲtransporterintargeting mRNPstomammalianprocessingbodies."RNA11(5):717Ͳ27.

Andrews,J.L.,A.C.Kim,etal.(2012)."Theroleandfunctionofcadherinsinthemammary gland."BreastCancerRes14(1):203.

Ansieau,S.(2013)."EMTinbreastcancerstemcellgeneration."CancerLett338(1):63Ͳ8.

Armengol,G.,F.Rojo,etal.(2007)."4EͲbindingprotein1:akeymolecular"funnelfactor"in humancancerwithclinicalimplications."CancerRes67(16):7551Ͳ5.

Avdulov,S.,S.Li,etal.(2004)."ActivationoftranslationcomplexeIF4Fisessentialforthe genesisandmaintenanceofthemalignantphenotypeinhumanmammaryepithelial cells."CancerCell5(6):553Ͳ63.

Bain,J.,L.Plater,etal.(2007)."Theselectivityofproteinkinaseinhibitors:afurtherupdate." BiochemJ408(3):297Ͳ315.

Banerjee,A.K.(1980)."5'Ͳterminalcapstructureineucaryoticmessengerribonucleicacids." MicrobiolRev44(2):175Ͳ205.

Banko,J.L.,L.Hou,etal.(2004)."NMDAreceptoractivationresultsinPKAͲandERKͲdependent Mnk1activationandincreasedeIF4EphosphorylationinhippocampalareaCA1."J Neurochem91(2):462Ͳ70.

Bauer,C.,I.Diesinger,etal.(2001)."TranslationinitiationfactoreIFͲ4Gisimmunogenic, overexpressed,andamplifiedinpatientswithsquamouscelllungcarcinoma."Cancer

92(4):822Ͳ9.

Beghi,E.,A.Azzoni,etal.(1990)."[Studygroup:"Evaluationoftheefficacyoftherapeutic treatmentsinepilepsy"]."EpidemiolPrev12(43):21Ͳ7.

Bianchini,A.,M.Loiarro,etal.(2008)."PhosphorylationofeIF4EbyMNKssupportsprotein synthesis, cell cycle progression and proliferation in prostate cancer cells." Carcinogenesis29(12):2279Ͳ88.

Bilanges,B.andD.Stokoe(2007)."Mechanismsoftranslationalderegulationinhumantumors andtherapeuticinterventionstrategies."Oncogene26(41):5973Ͳ90.

Braun,J.E.,E.Huntzinger,etal.(2012)."AmolecularlinkbetweenmiRISCsanddeadenylases providesnewinsightintothemechanismofgenesilencingbymicroRNAs."ColdSpring HarbPerspectBiol4(12).

Breier,G.,M.Grosser,etal.(2014)."Endothelialcadherinsincancer."CellTissueRes.

Brenner,S.,A.O.Stretton,etal.(1965)."Geneticcode:the'nonsense'tripletsforchain terminationandtheirsuppression."Nature206(988):994Ͳ8.

Bu,X.andC.H.Hagedorn(1992)."Phosphoproteinphosphatase2AdephosphorylateseIFͲ4E anddoesnotalterbindingtothemRNAcap."FEBSLett301(1):15Ͳ8.

Buchan,J.R.andR.Parker(2009)."Eukaryoticstressgranules:theinsandoutsoftranslation." MolCell36(6):932Ͳ41.

Buendia,A.J.,C.PenafielͲVerdu,etal.(2013)."NͲcadherinExpressioninFelineMammary TumorsIsAssociatedWithaReducedEͲcadherinExpressionandthePresenceof RegionalMetastasis."VetPathol.

Ͳ134Ͳ

Bundschu,K.,U.Walter,etal.(2006)."TheVASPͲSpredͲSproutydomainpuzzle."JBiolChem

281(48):36477Ͳ81.

Buxade,M.,N.Morrice,etal.(2008)."ThePSF.p54nrbcomplexisanovelMnksubstratethat bindsthemRNAfortumornecrosisfactoralpha."JBiolChem283(1):57Ͳ65.

Buxade,M.,J.L.Parra,etal.(2005)."TheMnksarenovelcomponentsinthecontrolofTNF alphabiosynthesisandphosphorylateandregulatehnRNPA1."Immunity23(2):177Ͳ89. Byrnes,K.,S.White,etal.(2006)."HigheIF4E,VEGF,andmicrovesseldensityinstageItoIII

breastcancer."AnnSurg243(5):684Ͳ90;discussion691Ͳ2.

Cargnello,M.,J.Tcherkezian,etal.(2012)."Phosphorylationoftheeukaryotictranslation initiationfactor4EͲtransporter (4EͲT)bycͲJunNͲterminalkinasepromotesstressͲ dependentPͲbodyassembly."MolCellBiol32(22):4572Ͳ84.

Caron,S.,M.Charon,etal.(2004)."Selectivemodificationofeukaryoticinitiationfactor4F (eIF4F)attheonsetofcelldifferentiation:recruitmentofeIF4GIIandlongͲlasting phosphorylationofeIF4E."MolCellBiol24(11):4920Ͳ8.

Carroll,M.andK.L.Borden(2013)."TheoncogeneeIF4E:usingbiochemicalinsightstotarget cancer."JInterferonCytokineRes33(5):227Ͳ38.

Castellvi,J.,A.Garcia,etal.(2006)."Phosphorylated4Ebindingprotein1:ahallmarkofcell signalingthatcorrelateswithsurvivalinovariancancer."Cancer107(8):1801Ͳ11.

Castellvi,J.,A.Garcia,etal.(2009)."Cellsignalinginendometrialcarcinoma:phosphorylated4EͲ bindingproteinͲ1expressioninendometrialcancercorrelateswithaggressivetumors andprognosis."HumPathol40(10):1418Ͳ26.

Cavigelli,M.,W.W.Li,etal.(1996)."ThetumorpromoterarsenitestimulatesAPͲ1activityby inhibitingaJNKphosphatase."EMBOJ15(22):6269Ͳ79.

Clemens,M.J.(2004)."Targetsandmechanismsfortheregulationoftranslationinmalignant transformation."Oncogene23(18):3180Ͳ8.

Cohen,N.,M.Sharma,etal.(2001)."PMLRINGsuppressesoncogenictransformationby reducingtheaffinityofeIF4EformRNA."EMBOJ20(16):4547Ͳ59.

Coldwell,M.J.,U.Sack,etal.(2012)."Multipleisoformsofthetranslationinitiationfactor eIF4GIIaregeneratedviauseofalternativepromoters,splicesitesandanonͲcanonical initiationcodon."BiochemJ448(1):1Ͳ11.

Coller,J.andR.Parker(2004)."EukaryoticmRNAdecapping."AnnuRevBiochem73:861Ͳ90. Coussens,L.M.andZ.Werb(1996)."Matrixmetalloproteinasesandthedevelopmentof

cancer."ChemBiol3(11):895Ͳ904.

Cuenda,A.,J.Rouse,etal.(1995)."SB203580isaspecificinhibitorofaMAPkinasehomologue whichisstimulatedbycellularstressesandinterleukinͲ1."FEBSLett364(2):229Ͳ33. Culjkovic,B.,K.Tan,etal.(2008)."TheeIF4ERNAregulonpromotestheAktsignalingpathway."

JCellBiol181(1):51Ͳ63.

Culjkovic,B.,I.Topisirovic,etal.(2007)."ControllinggeneexpressionthroughRNAregulons:the roleoftheeukaryotictranslationinitiationfactoreIF4E."CellCycle6(1):65Ͳ9.

Culjkovic,B.,I.Topisirovic,etal.(2006)."eIF4EisacentralnodeofanRNAregulonthatgoverns cellularproliferation."JCellBiol175(3):415Ͳ26.

Chaudhry,Y.,A.Nayak,etal.(2006)."Calicivirusesdifferintheirfunctionalrequirementsfor eIF4Fcomponents."JBiolChem281(35):25315Ͳ25.

Chaudhuri,J.,D.Chowdhury,etal.(1999)."Distinctfunctionsofeukaryotictranslationinitiation factorseIF1AandeIF3intheformationofthe40Sribosomalpreinitiationcomplex."J BiolChem274(25):17975Ͳ80.

Chen,Y.C.,S.Y.LinͲShiau,etal.(1998)."Involvementofreactiveoxygenspeciesandcaspase3 activationinarseniteͲinducedapoptosis."JCellPhysiol177(2):324Ͳ33.

DeBenedetti,A.andJ.R.Graff(2004)."eIFͲ4Eexpressionanditsroleinmalignanciesand metastases."Oncogene23(18):3189Ͳ99.

DeBenedetti,A.andA.L.Harris(1999)."eIF4Eexpressionintumors:itspossiblerolein progressionofmalignancies."IntJBiochemCellBiol31(1):59Ͳ72.

Ͳ135Ͳ

DeBenedetti,A.,S.JoshiͲBarve,etal.(1991)."ExpressionofantisenseRNAagainstinitiation factoreIFͲ4EmRNAinHeLacellsresultsinlengthenedcelldivisiontimes,diminished translationrates,andreducedlevelsofbotheIFͲ4Eandthep220componentofeIFͲ4F." MolCellBiol11(11):5435Ͳ45.

DeBenedetti,A.andR.E.Rhoads(1990)."Overexpressionofeukaryoticproteinsynthesis initiationfactor4EinHeLacellsresultsinaberrantgrowthandmorphology."ProcNatl AcadSciUSA87(21):8212Ͳ6.

DeFatta,R.J.,C.O.Nathan,etal.(2000)."AntisenseRNAtoeIF4Esuppressesoncogenic propertiesofaheadandnecksquamouscellcarcinomacellline."Laryngoscope110(6): 928Ͳ33.

Detzer,A.,C.Engel,etal.(2011)."CellstressisrelatedtoreͲlocalizationofArgonaute2andto decreasedRNAinterferenceinhumancells."NucleicAcidsRes39(7):2727Ͳ41.

Dobrikov,M.,E.Dobrikova,etal.(2011)."Phosphorylationofeukaryotictranslationinitiation factor4G1(eIF4G1)byproteinkinaseC{alpha}regulateseIF4G1bindingtoMnk1."Mol CellBiol31(14):2947Ͳ59.

Dong,K.,R.Wang,etal.(2009)."TumorͲspecificRNAitargetingeIF4Esuppressestumorgrowth, inducesapoptosisandenhancescisplatincytotoxicityinhumanbreastcarcinomacells." BreastCancerResTreat113(3):443Ͳ56.

Dostie,J.,M.Ferraiuolo,etal.(2000)."Anovelshuttlingprotein,4EͲT,mediatesthenuclear importofthemRNA5'capͲbindingprotein,eIF4E."EMBOJ19(12):3142Ͳ56.

Dostie,J.,F.Lejbkowicz,etal.(2000)."Nucleareukaryoticinitiationfactor4E(eIF4E)colocalizes withsplicingfactorsinspeckles."JCellBiol148(2):239Ͳ47.

Doudna,J.A.andV.L.Rath(2002)."Structureandfunctionoftheeukaryoticribosome:thenext frontier."Cell109(2):153Ͳ6.

Duncan,R.,S.C.Milburn,etal.(1987)."RegulatedphosphorylationandlowabundanceofHeLa cellinitiationfactoreIFͲ4Fsuggestaroleintranslationalcontrol.Heatshockeffectson eIFͲ4F."JBiolChem262(1):380Ͳ8.

Duncan,R.F.,H.Peterson,etal.(2003)."Oxidativestressincreaseseukaryoticinitiationfactor 4Ephosphorylationinvascularcells."BiochemJ369(Pt2):213Ͳ25.

Fan,S.,S.S.Ramalingam,etal.(2009)."Phosphorylatedeukaryotictranslationinitiationfactor4 (eIF4E)iselevatedinhumancancertissues."CancerBiolTher8(15):1463Ͳ9.

Feoktistova,K.,E.Tuvshintogs,etal.(2013)."HumaneIF4EpromotesmRNArestructuringby stimulatingeIF4Ahelicaseactivity."ProcNatlAcadSciUSA110(33):13339Ͳ44.

Ferraiuolo,M.A.,S.Basak,etal.(2005)."ArolefortheeIF4EͲbindingprotein4EͲTinPͲbody formationandmRNAdecay."JCellBiol170(6):913Ͳ24.

Filipowicz,W.,Y.Furuichi,etal.(1976)."Aproteinbindingthemethylated5'Ͳterminalsequence, m7GpppN,ofeukaryoticmessengerRNA."ProcNatlAcadSciUSA73(5):1559Ͳ63. Flowers,A.,Q.D.Chu,etal.(2009)."Eukaryoticinitiationfactor4EoverexpressionintripleͲ

negativebreastcancerpredictsaworseoutcome."Surgery146(2):220Ͳ6.

Flynn,A.andC.G.Proud(1995)."Serine209,notserine53,isthemajorsiteofphosphorylation ininitiationfactoreIFͲ4EinserumͲtreatedChinesehamsterovarycells."JBiolChem

270(37):21684Ͳ8.

Flynn,A.andG.Proud(1996)."InsulinͲstimulatedphosphorylationofinitiationfactor4Eis mediatedbytheMAPkinasepathway."FEBSLett389(2):162Ͳ6.

Fournier,M.J.,L.Coudert,etal.(2013)."InactivationofthemTORC1Ͳeukaryotictranslation initiationfactor4Epathwayaltersstressgranuleformation."MolCellBiol33(11):2285Ͳ 301.

Fraser,C.S.,V.M.Pain,etal.(1999)."Cellularstressinxenopuskidneycellsenhancesthe phosphorylationofeukaryotictranslationinitiationfactor(eIF)4Eandtheassociationof eIF4Fwithpoly(A)Ͳbindingprotein."BiochemJ342Pt3:519Ͳ26.

Frixen, U.H.,J.Behrens,et al. (1991)."EͲcadherinͲmediatedcellͲcell adhesionprevents invasivenessofhumancarcinomacells."JCellBiol113(1):173Ͳ85.

Ͳ136Ͳ

Fujimura,K.,A.T.Sasaki,etal.(2012)."SelenitetargetseIF4EͲbindingproteinͲ1toinhibit translationinitiationandinducetheassemblyofnonͲcanonicalstressgranules."Nucleic AcidsRes40(16):8099Ͳ110.

Fukunaga,R.andT.Hunter(1997)."MNK1,anewMAPkinaseͲactivatedproteinkinase,isolated byanovelexpressionscreeningmethodforidentifyingproteinkinasesubstrates." EMBOJ16(8):1921Ͳ33.

Furic,L.,L.Rong,etal.(2010)."eIF4Ephosphorylationpromotestumorigenesisandisassociated withprostatecancerprogression."ProcNatlAcadSciUSA107(32):14134Ͳ9.

Gallouzi,I.E.,C.M.Brennan,etal.(2000)."HuRbindingtocytoplasmicmRNAisperturbedby heatshock."ProcNatlAcadSciUSA97(7):3073Ͳ8.

Gingras,A.C.,B.Raught,etal.(1999)."eIF4initiationfactors:effectorsofmRNArecruitmentto ribosomesandregulatorsoftranslation."AnnuRevBiochem68:913Ͳ63.

Gradl, D., M. Kuhl, et al. (1999). "The Wnt/Wg signal transducer betaͲcatenin controls fibronectinexpression."MolCellBiol19(8):5576Ͳ87.

Graff,J.R.,E.R.Boghaert,etal.(1995)."Reductionoftranslationinitiationfactor4Edecreases themalignancyofrasͲtransformedclonedratembryofibroblasts."IntJCancer60(2): 255Ͳ63.

Graff,J.R.,B.W.Konicek,etal.(2008)."Targetingtheeukaryotictranslationinitiationfactor4E forcancertherapy."CancerRes68(3):631Ͳ4.

Graff,J.R.,B.W.Konicek,etal.(2007)."Therapeuticsuppressionoftranslationinitiationfactor eIF4Eexpressionreducestumorgrowthwithouttoxicity."JClinInvest117(9):2638Ͳ48. Graff,J.R.andS.G.Zimmer(2003)."Translationalcontrolandmetastaticprogression:enhanced

activityofthemRNAcapͲbindingproteineIFͲ4Eselectivelyenhancestranslationof metastasisͲrelatedmRNAs."ClinExpMetastasis20(3):265Ͳ73.

Gray,N.K.andM.Wickens(1998)."Controloftranslationinitiationinanimals."AnnuRevCell DevBiol14:399Ͳ458.

Grille,S.J.,A.Bellacosa,etal.(2003)."TheproteinkinaseAktinducesepithelialmesenchymal transitionandpromotesenhancedmotilityandinvasivenessofsquamouscellcarcinoma lines."CancerRes63(9):2172Ͳ8.

Haghighat,A.,S.Mader,etal.(1995)."RepressionofcapͲdependenttranslationby4EͲbinding protein1:competitionwithp220forbindingtoeukaryoticinitiationfactorͲ4E."EMBOJ

14(22):5701Ͳ9.

Hanahan,D.andR.A.Weinberg(2000)."Thehallmarksofcancer."Cell100(1):57Ͳ70.

Hanahan,D.andR.A.Weinberg(2011)."Hallmarksofcancer:thenextgeneration."Cell144(5): 646Ͳ74.

Harris,T.E.,A.Chi,etal.(2006)."mTORͲdependentstimulationoftheassociationofeIF4Gand eIF3byinsulin."EMBOJ25(8):1659Ͳ68.

Hazan,R.B.,L.Kang,etal.(1997)."NͲcadherinpromotesadhesionbetweeninvasivebreast cancercellsandthestroma."CellAdhesCommun4(6):399Ͳ411.

Hazan,R.B.,G.R.Phillips,etal.(2000)."ExogenousexpressionofNͲcadherininbreastcancer cellsinducescellmigration,invasion,andmetastasis."JCellBiol148(4):779Ͳ90.

Hazan,R.B.,R.Qiao,etal.(2004)."Cadherinswitchintumorprogression."AnnNYAcadSci

1014:155Ͳ63.

Heesom, K. J., A. Gampel, et al. (2001). "Cell cycleͲdependent phosphorylation of the translationalrepressoreIFͲ4EbindingproteinͲ1(4EͲBP1)."CurrBiol11(17):1374Ͳ9. Heinonen,M.,R.Fagerholm,etal.(2007)."PrognosticroleofHuRinhereditarybreastcancer."

ClinCancerRes13(23):6959Ͳ63.

Herbert,T.P.,A.R.Tee,etal.(2002)."TheextracellularsignalͲregulatedkinasepathway regulatesthephosphorylationof4EͲBP1atmultiplesites."JBiolChem277(13):11591Ͳ 6.

Hershey,J.W.,N.Sonenberg,etal.(2012)."Principlesoftranslationalcontrol:anoverview." ColdSpringHarbPerspectBiol4(12).

Ͳ137Ͳ

Hiller,D.J.,Q.Chu,etal.(2009)."PredictivevalueofeIF4Ereductionafterneoadjuvanttherapy inbreastcancer."JSurgRes156(2):265Ͳ9.

Hinnebusch,A.G.(2011)."Molecularmechanismofscanningandstartcodonselectionin eukaryotes."MicrobiolMolBiolRev75(3):434Ͳ67,firstpageoftableofcontents. Hock,J.,L.Weinmann,etal.(2007)."ProteomicandfunctionalanalysisofArgonauteͲcontaining

mRNAͲproteincomplexesinhumancells."EMBORep8(11):1052Ͳ60.

Hou,J.,F.Lam,etal.(2012)."TargetingMnksforcancertherapy."Oncotarget3(2):118Ͳ31. Hsieh,A.C.,Y.Liu,etal.(2012)."ThetranslationallandscapeofmTORsignallingsteerscancer

initiationandmetastasis."Nature485(7396):55Ͳ61.

Hu,Z.,C.Fan,etal.(2006)."Themolecularportraitsofbreasttumorsareconservedacross microarrayplatforms."BMCGenomics7:96.

Hulit,J.,K.Suyama,etal.(2007)."NͲcadherinsignalingpotentiatesmammarytumormetastasis viaenhancedextracellularsignalͲregulatedkinaseactivation."CancerRes67(7):3106Ͳ 16.

Imataka,H.,A.Gradi,etal.(1998)."AnewlyidentifiedNͲterminalaminoacidsequenceof human eIF4G binds poly(A)Ͳbinding protein and functions in poly(A)Ͳdependent translation."EMBOJ17(24):7480Ͳ9.

Irigoyen,M.A.,F.V.Garcia,etal.(2011)."[Molecularsubtypesofbreastcancer:prognostic implicationsandclinicalandimmunohistochemicalcharacteristics]."AnSistSanitNavar

34(2):219Ͳ33.

JankowskaͲAnyszka,M.,B.J.Lamphear,etal.(1998)."Multipleisoformsofeukaryoticprotein synthesisinitiationfactor4EinCaenorhabditiseleganscandistinguishbetweenmonoͲ andtrimethylatedmRNAcapstructures."JBiolChem273(17):10538Ͳ42.

Jaramillo,M.,T.E.Dever,etal.(1991)."RNAunwindingintranslation:assemblyofhelicase complexintermediatescomprisingeukaryoticinitiationfactorseIFͲ4FandeIFͲ4B."Mol CellBiol11(12):5992Ͳ7.

Jones,R.M.,J.Branda,etal.(1996)."AnessentialEboxinthepromoterofthegeneencoding themRNAcapͲbindingprotein(eukaryoticinitiationfactor4E)isatargetforactivation bycͲmyc."MolCellBiol16(9):4754Ͳ64.

Joshi,B.,A.L.Cai,etal.(1995)."Phosphorylationofeukaryoticproteinsynthesisinitiationfactor 4EatSerͲ209."JBiolChem270(24):14597Ͳ603.

Joshi,B.,A.Cameron,etal.(2004)."CharacterizationofmammalianeIF4EͲfamilymembers."Eur JBiochem271(11):2189Ͳ203.

Joshi,B.,K.Lee,etal.(2005)."PhylogeneticanalysisofeIF4EͲfamilymembers."BMCEvolBiol5: 48.

Kalluri,R.andR.A.Weinberg(2009)."ThebasicsofepithelialͲmesenchymaltransition."JClin Invest119(6):1420Ͳ8.

Kamenska,A.,W.T.Lu,etal.(2014)."Human4EͲTrepressestranslationofboundmRNAsand enhancesmicroRNAͲmediatedsilencing."NucleicAcidsRes42(5):3298Ͳ313.

Kapp,L.D.andJ.R.Lorsch(2004)."GTPͲdependentrecognitionofthemethioninemoietyon initiatortRNAbytranslationfactoreIF2."JMolBiol335(4):923Ͳ36.

Kapp,L.D.andJ.R.Lorsch(2004)."Themolecularmechanicsofeukaryotictranslation."Annu RevBiochem73:657Ͳ704.

Kedersha,N.andP.Anderson(2002)."Stressgranules:sitesofmRNAtriagethatregulatemRNA stabilityandtranslatability."BiochemSocTrans30(Pt6):963Ͳ9.

Kedersha,N.,G.Stoecklin,etal.(2005)."Stressgranulesandprocessingbodiesaredynamically linkedsitesofmRNPremodeling."JCellBiol169(6):871Ͳ84.

Kedersha,N. L.,M.Gupta, etal.(1999)."RNAͲbindingproteinsTIAͲ1andTIARlinkthe phosphorylationofeIFͲ2alphatotheassemblyofmammalianstressgranules."JCell Biol147(7):1431Ͳ42.

Kerekatte,V.,K.Smiley,etal.(1995)."TheprotoͲoncogene/translationfactoreIF4E:asurveyof itsexpressioninbreastcarcinomas."IntJCancer64(1):27Ͳ31.

Ͳ138Ͳ

Klann,E.andJ.D.Sweatt(2008)."AlteredproteinsynthesisisatriggerforlongͲtermmemory formation."NeurobiolLearnMem89(3):247Ͳ59.

Kleiner,H.E.,P.Krishnan,etal.(2009)."TissuemicroarrayanalysisofeIF4Eanditsdownstream effectorproteinsinhumanbreastcancer."JExpClinCancerRes28:5.

Knauf,U.,C.Tschopp,etal.(2001)."NegativeregulationofproteintranslationbymitogenͲ activatedproteinkinaseͲinteractingkinases1and2."MolCellBiol21(16):5500Ͳ11. Koritzinsky,M.,M.G.Magagnin,etal.(2006)."Geneexpressionduringacuteandprolonged

hypoxiaisregulatedbydistinctmechanismsoftranslationalcontrol."EMBOJ25(5): 1114Ͳ25.

Koromilas,A.E.,A.LazarisͲKaratzas,etal.(1992)."mRNAscontainingextensivesecondary structureintheir5'nonͲcodingregiontranslateefficientlyincellsoverexpressing initiationfactoreIFͲ4E."EMBOJ11(11):4153Ͳ8.

Kozak,M.(1984)."Compilationandanalysisofsequencesupstreamfromthetranslationalstart siteineukaryoticmRNAs."NucleicAcidsRes12(2):857Ͳ72.

Kozak,M.(1989)."Thescanningmodelfortranslation:anupdate."JCellBiol108(2):229Ͳ41. Kozak,M.(1999)."Initiationoftranslationinprokaryotesandeukaryotes."Gene234(2):187Ͳ

208.

Kulkarni,M.,S.Ozgur,etal.(2010)."OntrackwithPͲbodies."BiochemSocTrans38(Pt1):242Ͳ 51.

Kwon,S.Y.,J. H.Lee,etal. (2014). "Complexity in RegulationofmicroRNA Machinery ComponentsinInvasiveBreastCarcinoma."PatholOncolRes.

Labelle,M.,H.J.Schnittler,etal.(2008)."Vascularendothelialcadherinpromotesbreastcancer progressionviatransforminggrowthfactorbetasignaling."CancerRes68(5):1388Ͳ97. Lamphear,B.J.,R.Kirchweger,etal.(1995)."Mappingoffunctionaldomainsineukaryotic

proteinsynthesisinitiationfactor4G(eIF4G)withpicornaviralproteases.Implications forcapͲdependentandcapͲindependenttranslationalinitiation."JBiolChem270(37): 21975Ͳ83.

Larsson,O.,S.Li,etal.(2007)."Eukaryotictranslationinitiationfactor4Einducedprogressionof primaryhumanmammaryepithelialcellsalongthecancerpathwayisassociatedwith targetedtranslationalderegulationofoncogenicdriversandinhibitors."CancerRes

67(14):6814Ͳ24.

Larue,L.andA.Bellacosa(2005)."EpithelialͲmesenchymaltransitionindevelopmentand cancer:roleofphosphatidylinositol3'kinase/AKTpathways."Oncogene24(50):7443Ͳ 54.

LazarisͲKaratzas,A.,K.S.Montine,etal.(1990)."Malignanttransformationbyaeukaryotic initiationfactorsubunitthatbindstomRNA5'cap."Nature345(6275):544Ͳ7.

Lee,H.C.,H.Cho,etal.(2008)."EctopicexpressionofeIF4EͲtransportertriggersthemovement ofeIF4EintoPͲbodies,inhibitingsteadyͲstatetranslationbutnotthepioneerroundof translation."BiochemBiophysResCommun369(4):1160Ͳ5.

Lejbkowicz,F.,C.Goyer,etal.(1992)."AfractionofthemRNA5'capͲbindingprotein,eukaryotic initiationfactor4E,localizestothenucleus."ProcNatlAcadSciUSA89(20):9612Ͳ6. Leopold,P.L.,J.Vincent,etal.(2012)."AcomparisonofepithelialͲtoͲmesenchymaltransition

andreͲepithelialization."SeminCancerBiol22(5Ͳ6):471Ͳ83.

Li,B.D.,L.Liu,etal.(1997)."Overexpressionofeukaryoticinitiationfactor4E(eIF4E)inbreast carcinoma."Cancer79(12):2385Ͳ90.

Li,S.,T.Takasu,etal.(2003)."TranslationfactoreIF4ErescuescellsfromMycͲdependent apoptosisbyinhibitingcytochromecrelease."JBiolChem278(5):3015Ͳ22.

Li,Y.,S.Fan,etal.(2012)."Elevatedexpressionofeukaryotictranslationinitiationfactor4Eis associatedwithproliferation,invasionandacquiredresistancetoerlotinibinlung cancer."CancerBiolTher13(5):272Ͳ80.

Ͳ139Ͳ

Li,Y.,P.Yue,etal.(2010)."Proteinphosphatase2Anegativelyregulateseukaryoticinitiation factor4EphosphorylationandeIF4FassemblythroughdirectdephosphorylationofMnk andeIF4E."Neoplasia12(10):848Ͳ55.

Lin,L.,T.Holbro,etal.(2001)."Molecularinteractionbetweenhumantumormarkerprotein p150,thelargestsubunitofeIF3,andintermediatefilamentproteinK7."JCellBiochem

80(4):483Ͳ90.

Lindsay,A.J.andM.W.McCaffrey(2011)."MyosinVaisrequiredforPbodybutnotstress granuleformation."JBiolChem286(13):11519Ͳ28.

Lobo,M.V.,M.E.Martin,etal.(2000)."Levels,phosphorylationstatusandcellularlocalization oftranslationalfactoreIF2ingastrointestinalcarcinomas."HistochemJ32(3):139Ͳ50. LopezdeSilanes,I.,M.Zhan,etal.(2004)."IdentificationofatargetRNAmotifforRNAͲbinding

proteinHuR."ProcNatlAcadSciUSA101(9):2987Ͳ92.

Lyabin,D.N.,I.A.Eliseeva,etal.(2014)."YBͲ1protein:functionsandregulation."Wiley InterdiscipRevRNA5(1):95Ͳ110.

Mader,S.,H.Lee,etal.(1995)."ThetranslationinitiationfactoreIFͲ4Ebindstoacommonmotif sharedbythetranslationfactoreIFͲ4gammaandthetranslationalrepressors4EͲ bindingproteins."MolCellBiol15(9):4990Ͳ7.

Majumdar,R.,A.Bandyopadhyay,etal.(2003)."MammaliantranslationinitiationfactoreIF1 functionswitheIF1AandeIF3intheformationofastable40Spreinitiationcomplex."J BiolChem278(8):6580Ͳ7.

Makkinje,A.,H.Xiong,etal.(1995)."Phosphorylationofeukaryoticproteinsynthesisinitiation factor4EbyinsulinͲstimulatedprotaminekinase."JBiolChem270(24):14824Ͳ8.

Mamane,Y.,E.Petroulakis,etal.(2004)."eIF4EͲͲfromtranslationtotransformation."Oncogene

23(18):3172Ͳ9.

Marcotrigiano,J.,A.C.Gingras,etal.(1997)."XͲraystudiesofthemessengerRNA5'capͲbinding protein(eIF4E)boundto7ͲmethylͲGDP."NucleicAcidsSympSer(36):8Ͳ11.

MazanͲMamczarz, K., S. Galban, et al. (2003). "RNAͲbinding protein HuR enhances p53 translationinresponsetoultravioletlightirradiation."ProcNatlAcadSciUSA100(14): 8354Ͳ9.

McClusky,D.R.,Q.Chu,etal.(2005)."Aprospectivetrialoninitiationfactor4E(eIF4E) overexpressionandcancerrecurrenceinnodeͲpositivebreastcancer."AnnSurg242(4): 584Ͳ90;discussion590Ͳ2.

McGrawͲHill(2012)."Biosíntesisdelasproteínas:Traducción."361Ͳ379.

McKendrick,L.,S.J.Morley,etal.(2001)."Phosphorylationofeukaryoticinitiationfactor4E (eIF4E)atSer209isnotrequiredforproteinsynthesisinvitroandinvivo."EurJBiochem

268(20):5375Ͳ85.

Micalizzi,D.S.,S.M.Farabaugh,etal.(2010)."EpithelialͲmesenchymaltransitionincancer: parallelsbetweennormaldevelopmentandtumorprogression."JMammaryGlandBiol Neoplasia15(2):117Ͳ34.

Mignatti,P.andD.B.Rifkin(1993)."Biologyandbiochemistryofproteinasesintumorinvasion." PhysiolRev73(1):161Ͳ95.

Minich, W. B., M. L. Balasta, et al. (1994). "Chromatographic resolution of in vivo phosphorylatedandnonphosphorylatedeukaryotictranslationinitiationfactoreIFͲ4E: increasedcapaffinityofthephosphorylatedform."ProcNatlAcadSciUSA91(16): 7668Ͳ72.

Minshall,N.,M.H.Reiter,etal.(2007)."CPEBinteractswithanovaryͲspecificeIF4Eand4EͲTin earlyXenopusoocytes."JBiolChem282(52):37389Ͳ401.

Mochizuki,K.,A.Oguro,etal.(2005)."HighaffinityRNAformammalianinitiationfactor4E interfereswithmRNAͲcapbindingandinhibitstranslation."RNA11(1):77Ͳ89.

Moerke,N.J.,H.Aktas,etal.(2007)."SmallͲmoleculeinhibitionoftheinteractionbetweenthe translationinitiationfactorseIF4EandeIF4G."Cell128(2):257Ͳ67.

Ͳ140Ͳ

Mokas,S.,J.R.Mills,etal.(2009)."Uncouplingstressgranuleassemblyandtranslationinitiation inhibition."MolBiolCell20(11):2673Ͳ83.

Morley,S.J.andL.McKendrick(1997)."InvolvementofstressͲactivatedproteinkinaseand p38/RK mitogenͲactivated protein kinase signaling pathways in the enhanced phosphorylationofinitiationfactor4EinNIH3T3cells."JBiolChem272(28):17887Ͳ93. Morley,S.J.andS.Naegele(2002)."Phosphorylationofeukaryoticinitiationfactor(eIF)4Eis

notrequiredfordenovoproteinsynthesisfollowingrecoveryfromhypertonicstressin humankidneycells."JBiolChem277(36):32855Ͳ9.

Related documents