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International Multiple Sclerosis Data Systems

Canadian Multiple Sclerosis Monitoring System: Environmental and Technic

Country Name Purpose

Status (Pilot/Active

/Inactive) Start Year Australia Australian MS

Longitudinal Study197

A nationwide project designed to facilitate new research of importance and potential benefit to people with MS and their families. The AAMSLS is intended to provide information about the full effects of MS on Australian society, including the individual and overall community cost.

Active 2001

Australian National Registry of MS Families (NRMSF)

To enable more powerful explorations into the genetic etiology of MS Inactive ?

Multiple Sclerosis Australia198 Provision of direct services to Australian residents living with multiple

sclerosis, with provision of confirmation of MS by neurologist Active ? Bosnia and

Herzegovina Unknown MS Barometer 2009—Final results (updated in 2010) indicate that a national MS register does exist. Less than 25% of persons living with MS were recorded on the register.143

– –

Canada Canadian Collaborative Project on Genetic Susceptibility in Multiple Sclerosis

(CCPGSMS) Study199, 200

The primary goal of the study is to direct efforts to pinpoint the gene or genes involved in the onset and development of MS and answer questions about the relative roles of genetic (inherited) and non-genetic

(environmental) factors in the etiology of MS

Active 1993

Croatia

(Hrvatska) Unknown MS Barometer 2009—Final results (updated in 2010) indicate that a national MS register does exist. Between 50% and 74% of persons living with MS were recorded on the register.143

– –

Germany MUSIS, SMile-Card, TQMS

Promise and MSDS201 Within the time frame that the MS-Forschungs-und Projektentwicklungs gGmbH project was initiated, a number of other MS database applications appear to be in use in Germany: MUSIS-Multiple Sclerosis Information System; SMile-Card; TQMS Promise and a new database system, MSDS (Multiple Sclerosis Documentation System), which, in 2002, was being implemented at 14 German hospitals (12 university hospitals, 1 general hospital and 1 rehabilitation hospital).

Greece Unknown MS Barometer 2009—Final results (updated in 2010) indicate that a national MS register does exist. Between 50% and 74% of persons living with MS were recorded on the register.143

– –

Iceland Unknown No national MS register as of 2009; however, Iceland participated in the EMSP MS-ID pilot (2007 to 2009) and the U.K. MS Society contact indicated one may now be in place143

Latvia HI Register of MS, Multiple Sclerosis Center Latvian Maritime Medicine Center202

MS Barometer 2009—Final results (updated in 2010) indicate that a national MS register does exist. Between 75% and 94% of persons living with MS were recorded on the register.143

Active 1997

an Multiple Sclerosis Monitoring System: Environmental and Technical Scan

Country Name Purpose

Status (Pilot/Active

/Inactive) Start Year Malta Unknown MS Barometer 2009—Final results (updated in 2010) indicate a national

MS register does exist. Between 25% and 49% of persons living with MS were recorded on the register.143

New Zealand (Aotearoa)

New Zealand National MS

Prevalence Study (NZMSPS)203 In 2007, a research team located at universities of Otago and Canterbury launched the first national prevalence survey on MS (funded jointly by the Health Research Council and the MS Society in conjunction with the MS Society of NZ). The NZMSPS is a cross-sectional study of people with definite MS (DMS) (McDonald criteria 2005) who were a resident in New Zealand on census night, March 7, 2006. Study appears to be ongoing and has as a stated goal “to determine the level of interest among participants in establishing a New Zealand multiple sclerosis register.”

Active 2007

Russian Federation

Unknown MS Barometer 2009—Final results (updated in 2010) indicate that a national MS register does exist. Between 50% and 74% of persons living with MS were recorded on the register.143

Slovenia Unknown MS Barometer 2009—Final results (updated in 2010) indicate that a national MS register does exist. Between 50% and 74% of persons living with MS were recorded on the register.143

– –

United

States Spinal Cord Dysfunction (SCD)

Registry, Veterans Affairs204 The veteran population served is tracked for clinical, administrative and outcome purposes by the SCD Registry minimal data set. Through the registration of veterans within the SCI hub and spokes system, this tool provides a database linked to other Veterans Health Information System and Technology Architecture (VistA) files, allowing providers to track veterans admitted and discharged within the medical centre and to review utilization of laboratory, pharmacy, inpatient and outpatient resources.

The local SCD Registry is also used to capture clinical aspects of care and outcome measures.

Active ?

Source

See references cited in the table.

References

1. J. F. Kurtzke, “Rating Neurologic Impairment in Multiple Sclerosis: An Expanded Disability Status Scale (EDSS),” Neurology 33, 11 (1983): pp. 1444–1452.

2. Multiple Sclerosis International Federation et al., Global Economic Impact of Multiple Sclerosis (2010), accessed from <http://www.msif.org/en/resources/msif_resources/msif_publications/

global_economic_impact_of_ms/index.html>.

3. H. Tremlett et al., “New Perspectives in the Natural History of Multiple Sclerosis,”

Neurology 74, 24 (2010): pp. 2004–2015.

4. World Health Organization and Multiple Sclerosis International Federation, Atlas: Multiple Sclerosis Resources in the World 2008 (2008), accessed from

<http://www.who.int/mental_health/neurology/Atlas_MS_WEB.pdf>.

5. Multiple Sclerosis Society of Canada, Estimated Number of Canadians With Multiple Sclerosis Re-Examined, accessed on July 17, 2011, from <http://mssociety.ca/en/releases/

NR_May06.htm>.

6. S.-M. Orton et al., “Sex Ratio of Multiple Sclerosis in Canada: A Longitudinal Study,”

The Lancet Neurology 5 (2006): pp. 932–936.

7. National Multiple Sclerosis Society, What Is Multiple Sclerosis?, accessed on October 20, 2011, from <http://www.nationalmssociety.org/about-multiple-sclerosis/

what-we-know-about-ms/what-is-ms/index.aspx>.

8. F. D. Lublin and S. C. Reingold, “Defining the Clinical Course of Multiple Sclerosis,”

Neurology 46, 4 (1996): pp. 907–911.

9. Canadian Institute for Health Information, The Burden of Neurological Diseases, Disorders and Injuries in Canada (Ottawa, 2007), accessed from

<http://secure.cihi.ca/cihiweb/products/BND_e.pdf>.

10. World Health Organization, Neurological Disorders: Public Health Challenges (2006).

11. T. J. Murray, “Diagnosis and Treatment of Multiple Sclerosis,” British Medical Journal 332 (2006): pp. 525–527, accessed from <http://www.direct-ms.org/pdf/ImmunologyMS/

Murray%20review%20MS.pdf>.

12. National Multiple Sclerosis Society, What Causes MS?, accessed on August 8, 2011, from

<http://www.nationalmssociety.org/about-multiple-sclerosis/what-we-know-about-ms/

what-causes-ms/index.aspx>.

13. R. A. Marrie, “Environmental Risk Factors in Multiple Sclerosis Aetiology,” The Lancet Neurology 3 (2004): pp. 709–718, accessed from <http://www.direct-ms.org/pdf/

CausalHypothesis/MarrieRiskFactors.pdf>.

14. D. M. Williamson, “Studies of Multiple Sclerosis in Communities Concerned About Environmental Exposures,” J Womens Health (Larchmt.) 15, 7 (2006): pp. 810–814.

15. K. Kakalacheva et al., “Viral Triggers of Multiple Sclerosis,” Biochimica Et Biophysica Acta 1812, 2 (2011): pp. 132–140, accessed from <http://www.sciencedirect.com/

science?_ob=ArticleListURL&_method=list&_ArticleListID=1793760079&_sort=r&_st=

13&view=c&_acct=C000072520&_version=1&_urlVersion=0&_userid=7671283&md5=a44 ad8a41d66f2ac91d034ff2609be98&searchtype=a>.

16. U. Leibowitz et al., “Epidemiological Study of Multiple Sclerosis in Israel: Part II Multiple Sclerosis and Level of Sanitation,” J Neurol.Neurosurg.Psychiatry 29 (1966): pp. 60–68, accessed on August 8, 2011, from <http://www.ncbi.nlm.nih.gov/pmc/articles/

PMC495985/pdf/jnnpsyc00241-0064.pdf>.

17. S. Sotgiu et al., “Does the ‘Hygiene Hypothesis’ Provide an Explanation for the High Prevalence of Multiple Sclerosis in Sardinia?,” Autoimmunity 36, 5 (2003): pp. 257–260, accessed on August 8, 2011, from <http://www.direct-ms.org/pdf/HygieneMS/

SotguiSardiniaHygiene.pdf>.

18. J. O. Fleming and T. D. Cook, “Multiple Sclerosis and the Hygiene Hypothesis,” Neurology 67 (2006): pp. 2085–2086, accessed on August 8, 2011, from <http://www.direct-ms.org/

pdf/HygieneMS/Fleming%20MS%20Hygiene%20Hypoth.pdf>.

19. A. D. Sadovnick et al., “Multiple Sclerosis and Birth Order: A Longitudinal Cohort Study,”

The Lancet Neurology 4, 10 (2005): pp. 611–617, accessed on October 20, 2011, from

<http://www.sciencedirect.com/science/article/pii/S1474442205701708>.

20. G. C. Ebers et al., “Parent-of-Origin Effect in Multiple Sclerosis: Observations in Half-Siblings,” The Lancet Neurology 363 (2004): pp. 1773–1774, accessed from

<http://www.direct-ms.org/pdf/GeneticsMS/HalfSiblingMS.pdf>.

21. Multiple Sclerosis Resource Centre, Causes of MS, accessed on September 24, 2011, from <http://www.msrc.co.uk/index.cfm/fuseaction/show/pageid/746>.

22. Multiple Sclerosis Resource Centre, The Venous Connection to MS—A Timeline, accessed on September 24, 2011, from <http://www.msrc.co.uk/index.cfm/

fuseaction/show/pageid/2953>.

23. P. Zamboni et al., “Chronic Cerebrospinal Venous Insufficiency in Patients With Multiple Sclerosis,” Journal of Neurology, Neurosurgery and Psychology 80 (2008): pp. 392–399.

24. ScienceDaily, Neurologists Investigate Possible New Underlying Cause Of Multiple Sclerosis, accessed on September 24, 2011, from

<http://www.sciencedaily.com/releases/2009/10/091023163358.htm>.

25. R. J. Fox and Cleveland Clinic, Multiple Sclerosis, accessed on July 17, 2011, from

<http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/neurology/

multiple_sclerosis/>.

26. M. S. Freedman, “Long-Term Follow-Up of Clinical Trials of Multiple Sclerosis Therapies,”

Neurology 76, 1 Suppl 1 (2011): pp. S26–S34.

27. National Multiple Sclerosis Society, National MS Society: Diagnosing MS, accessed from

<http://www.nationalmssociety.org/about-multiple-sclerosis/what-we-know-about-ms/

diagnosing-ms/index.aspx>.

28. R. A. Marrie et al., “Comorbidity Delays Diagnosis and Increases Disability at Diagnosis in MS,” Neurology 72 (2009): pp. 117–124.

29. D. H. Miller et al., “Differential Diagnosis of Suspected Multiple Sclerosis: A Consensus Approach,” Multiple Sclerosis 14 (2008): pp. 1157–1174.

30. T. J. Murray, Multiple Sclerosis: The History of a Disease (Demos Medical Publishing, 2005), pp. 488–503.

31. C. Poser et al., “New Diagnostic Criteria for Multiple Sclerosis: Guidelines for Research Protocols,” Ann Neurol 13, 3 (1983): pp. 227–231.

32. I. McDonald et al., “Recommended Diagnostic Criteria for Multiple Sclerosis: Guidelines From the International Panel on the Diagnosis of Multiple Sclerosis,” Ann Neurol 50, 1 (2001): pp. 121–127.

33. C. Polman et al., “Diagnostic Criteria for Multiple Sclerosis: 2005 Revisions to the McDonald Criteria,” Ann Neurol 58, 6 (2005): pp. 840–846.

34. C. Polman et al., “Diagnostic Criteria for Multiple Sclerosis: 2010 Revisions to the McDonald Criteria,” Ann Neurol 69, 2 (2011): pp. 292–302.

35. National Multiple Sclerosis Society, Resources for Clinicians, accessed on August 8, 2011, from <http://www.nationalmssociety.org/for-professionals/healthcare-professionals/

resources-for-clinicians/index.aspx>.

36. National Multiple Sclerosis Society, Tip Sheet 2010 Revised McDonald Diagnostic Criteria for MS, accessed on August 8, 2011, from <http://www.nationalmssociety.org/

for-professionals/healthcare-professionals/resources-for-clinicians/download.asp?id=29943>.

37. Multiple Sclerosis Society of Canada, Treatments, accessed on July 25, 2011, from

<http://mssociety.ca/en/treatments/modify.htm>.

38. National Multiple Sclerosis Society, The MS Disease—Modifying Medications: General Information (2010).

39. National Multiple Sclerosis Society, Treatments, accessed on July 17, 2011, from

<http://www.nationalmssociety.org/about-multiple-sclerosis/what-we-know-about-ms/

treatments/index.aspx>.

40. J. Smolders, “Vitamin D and Multiple Sclerosis: Correlation, Causality and Controversy,”

Autoimmune Diseases 2011 (2011): pp. 1–3, accessed from

<http://www.hindawi.com/journals/ad/2011/629538/>.

41. H. E. Hanwell and B. Banwell, “Assessment of evidence for a protective role of vitamin D in multiple sclerosis,” Biochimica et Biophysica Acta 1812, 2 (February 2011): pp. 202–212.

42. A. Huntley and E. Ernst, “Complementary and Alternative Therapies for Treating Multiple Sclerosis Symptoms: a Systematic Review,” Complementary Therapies in Medicine 8, 2 (2000): pp. 97–105, accessed on August 9, 2011, from

<http://www.sciencedirect.com/science/article/pii/S0965229900903662>.

43. Multiple Sclerosis Resource Centre, MS Research News, accessed on August 9, 2011, from <http://www.msrc.co.uk/index.cfm/fuseaction/show/pageid/7>.

44. ScienceDaily, Exercise Helps Protect Brain of Multiple Sclerosis Patients, Study Suggests, accessed on October 20, 2011, from

<http://www.sciencedaily.com/releases/2010/02/100218141813.htm>.

45. M. P. Wattjes et al., “No Association of Abnormal Cranial Venous Drainage With Multiple Sclerosis: A Magnetic Resonance Venography and Flow-Quantification Study,” J

Neurol.Neurosurg.Psychiatry (2010).

46. CBC News, Lack of MS Treatment Followup Frustrates Patient, accessed on July 17, 2011, from <http://www.cbc.ca/news/canada/ottawa/story/2010/11/17/

ottawa-ms-treatment.html>.

47. CBC News, Ontario Man Dies After MS Vein Opening, accessed on July 17, 2011, from

<http://www.cbc.ca/news/health/story/2010/11/18/multiple-sclerosis-vein-death-costa-rica-mostic.html>.

48. CBC News, 2nd Canadian Dies After MS Surgery, accessed on July 17, 2011, from

<http://www.cbc.ca/news/health/story/2011/07/08/multiple-sclerosis-ccsvi-death.html>.

49. A. Ferlini et al., “Custom CGH Array Profiling of Copy Number Variations (CNVs) on Chromosome 6p21.32 (HLA Locus) in Patients With Venous Malformations Associated With Multiple Sclerosis,” BMC Medical Genetics 11 (April 28, 2010), p. 64.

50. S. Sanna et al., “Variants Within the Immunoregulatory CBLB Gene Are Associated With Multiple Sclerosis,” Nature Genetics 42, 6 (2010): pp. 495–497.

51. The International Multiple Sclerosis Genetics Consortium and The Wellcome Trust Case Control Consortium 2, “Genetic Risk and a Primary Role for Cell-Mediated Immune Mechanisms in Multiple Sclerosis,” Nature 476 (2011): pp. 214–219, accessed on October 20, 2011, from

<http://www.nature.com/nature/journal/v476/n7359/full/nature10251.html>.

52. S. V. Ramagopalan et al., “The Inheritance of Resistance Alleles in Multiple Sclerosis,”

PLoS Genetics 3, 9 (2007): pp. 1607–1613, accessed on October 20, 2011, from

<http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971120/?tool=pubmed>.

53. F. E. Nashold et al., “Estrogen Controls Vitamin D3-Mediated Resistance to Experimental Autoimmune Encephalomyelitis by Controlling Vitamin D3 Metabolism and Receptor Expression,” Journal of Immunology 183, 6 (2009): pp. 3672–3681.

54. Multiple Sclerosis International Federation, MS in Focus: MS in Research (Cambridge Publishers Ltd., 2011).

55. G. Disanto et al., “Heterogeneity in Multiple Sclerosis: Scratching the Surface of a Complex Disease,” Autoimmune Diseases (2011), accessed from

<http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005811/?tool=pubmed>.

56. J. Correale and M. F. Farez, “The Impact of Parasite Infections on the Course of Multiple Sclerosis,” Journal of Neuroimmunology 233 (2011): pp. 6–11.

57. Disabled World, Diabled World—First Oral Treatment for MS Made Available in Canada, accessed on July 17, 2011, from <http://www.disabled-world.com/health/

autoimmunediseases/ms/gilenya-fingolimod.php>.

58. Pharmaceutical Research and Manufacturers of America, Innovation.Org, accessed on August 8, 2011, from <http://www.phrma.org/newmeds/?skin=innovation&reskin>.

59. Stem Cell Network, Multiple Sclerosis, accessed on August 8, 2011, from

<http://www.stemcellnetwork.ca/index.php?page=multiple-sclerosis&hl=eng>.

60. I. Hyun et al., “New ISSCR Guidelines Underscore Major Principles for Responsible Translational Stem Cell Research,” Cell Stem Cell 3 (2008): pp. 607–609, accessed on October 20, 2011, from <http://download.cell.com/cell-stem-cell/pdf/

PIIS1934590908005808.pdf?intermediate=true>.

61. International Society for Stem Cell Research, Top Ten Things to Know About Stem Cell Treatments, accessed on October 20, 2011, from

<http://www.closerlookatstemcells.org/Top_10_Stem_Cell_Treatment_Facts.htm>.

62. Multiple Sclerosis Society of Canada, CCSVI and MS, accessed from

<http://ccsvi.ca/ccsvi.html>.

63. Multiple Sclerosis Society of Canada, Over $2.4 Million Committed to Support Seven Operating Grants to Explore the Relationship of CCSVI to Multiple Sclerosis, accessed on July 12, 2011, from <http://mssociety.ca/en/releases/nr_20100611.htm>.

64. Government of Canada, Statement by Minister Aglukkaq on Chronic Cerebrospinal Venous Insufficiency and Multiple Sclerosis, accessed on July 12, 2011, from

<http://www.hc-sc.gc.ca/ahc-asc/media/nr-cp/_2011/2011_87-eng.php>.

65. D. W. Paty, “The Canadian Experience: Multiple Sclerosis Clinics Versus Traditional Medical Care, and What Made Multiple Sclerosis Research Flourish in Canada?,”

Advances in Multiple Sclerosis Clinical Research and Therapy (Stockholm, Sweden:

Martin Dunitz Ltd., 1999), pp. 203–210.

66. Multiple Sclerosis Society of Canada, Living With MS: MS Clinics, accessed on July 18, 2011, from <http://mssociety.ca/en/help/clinics.htm>.

67. Public Health Agency of Canada, About the Agency, accessed on July 31, 2011, from

<http://www.phac-aspc.gc.ca/about_apropos/index-eng.php>.

68. Government of Canada, Government of Canada Announces New Monitoring System for Multiple Sclerosis, accessed from <http://www.phac-aspc.gc.ca/media/nr-rp/

2011/2011_0323-eng.php>.

69. Public Health Agency of Canada, Responding to the Challenge of Diabetes in Canada.

First Report of the National Diabetes Surveillance System (NDSS) 2003 (2003), accessed from <http://www.phac-aspc.gc.ca/ccdpc-cpcmc/ndss-snsd/english/pubs_reports/

pdf/WEB_NDSS_English_Report-nocover.pdf>.

70. Public Health Agency of Canada, Report From the Canadian Chronic Disease Surveillance System: Hypertension in Canada, 2010 (2010), accessed from

<http://www.phac-aspc.gc.ca/cd-mc/cvd-mcv/ccdss-snsmc-2010/pdf/

CCDSS_HTN_Report_FINAL_EN_20100513.pdf>.

71. Public Health Agency of Canada, Government of Canada Announces First-Ever National Study on Neurological Diseases, accessed on July 12, 2011, from

<http://www.phac-aspc.gc.ca/media/nr-rp/2009/2009_0605-eng.php>.

72. Statistics Canada, Canadian Community Health Survey—Annual Component (CCHS), accessed from <http://www.statcan.gc.ca/cgi-bin/imdb/p2SV.pl?Function=

getSurvey&SDDS=3226&lang=en&db=imdb&adm=8&dis=2>.

73. Email to Tammy Anderson, Program Consultant, Canadian Multiple Sclerosis Monitoring System, Health Spending and Strategic Initiatives Branch, CIHI, from Neetu Shukla, MPH, Analyst, Collaboration and Development Section, Public Health Agency of Canada, Centre for Chronic Disease Prevention and Control, Chronic Disease Surveillance and Monitoring Division, July 29, 2011.

74. Statistics Canada, Statistics Canada: Mandate and Objectives, accessed on July 18, 2011, from <http://www.statcan.gc.ca/about-apercu/mandate-mandat-eng.htm>.

75. N. Shukla and Public Health Agency of Canada, NPHSNC—Overview of Funded Projects (2011).

76. M. Rowat and Statistics Canada, CCHS Data and Multiple Sclerosis (2011).

77. Statistics Canada, Health Models: Microsimulation in Health, accessed on July 18, 2011, from <http://www.statcan.gc.ca/microsimulation/health-sante/health-sante-eng.htm>.

78. Health Canada, Access to Therapeutic Products: The Regulatory Process in Canada, accessed on July 18, 2011, from <http://www.hc-sc.gc.ca/ahc-asc/pubs/

hpfb-dgpsa/access-therapeutic_acces-therapeutique-eng.php>.

79. Health Canada, Health Canada Endorsed Important Safety Information on Tysabri (Natalizumab), accessed on July 20, 2011, from <http://www.hc-sc.gc.ca/

dhp-mps/medeff/advisories-avis/prof/_2009/tysabri_2_hpc-cps-eng.php>.

80. Canadian Agency for Drugs and Technologies in Health, About the Canadian Agency for Drugs and Technologies in Health, accessed on July 18, 2011, from

<http://www.cadth.ca/en/cadth>.

81. Canadian Agency for Drugs and Technologies in Health, Neurology, accessed on July 27, 2011, from <http://www.cadth.ca/en/priorities/neurology>.

82. Canadian Agency for Drugs and Technologies in Health, An Update on the Investigation of Chronic Cerebrospinal Venous Insufficiency for the Treatment of Multiple Sclerosis (2011).

83. Canadian Agency for Drugs and Technologies in Health, Investigating Chronic Cerebrospinal Venous Insufficiency for the Treatment of Multiple Sclerosis (2010), accessed from

<http://www.cadth.ca/media/pdf/Chronic_Cerebrospinal_Venous_Insufficiency_MS_es.15_e.pdf>.

84. Canadian Agency for Drugs and Technologies in Health, Range of Motion Therapy for Patients With Multiple Sclerosis: Clinical Effectiveness and Guidelines (2010), accessed from <http://www.cadth.ca/media/pdf/j0457_range_motion_patients_with_ms_htis-2.pdf>.

85. Multiple Sclerosis Society of Canada, Multiple Sclerosis Society of Canada: About Us, accessed on July 8, 2011, from <http://mssociety.ca/en/community/mssc/default.htm>.

86. endMS Research and Training Network, Welcome to the EndMS Research and Training Network, accessed on October 25, 2011, from

<https://www.endmsnetwork.ca/en/Pages/default.aspx>.

87. endMS Research and Training Network, EndMS RRTCs, accessed on October 25, 2011, from <https://www.endmsnetwork.ca/en/RegionalCentres/Pages/default.aspx>.

88. Canadian Institutes of Health Research, Our Mission, accessed on July 18, 2011, from

<http://www.cihr-irsc.gc.ca/e/7263.html>.

89. Rx&D Health Research Foundation, Innovative Partnership Provides Important Funding for Mental Disorders and Palliative Care Research, accessed on July 15, 2011, from

<https://www.canadapharma.org/en/documents/NewReleaseCIHR-HRFannouncementOct21finale.pdf >.

90. Canadian Institutes of Health Research, CIHR’s Funded Research Database, accessed on July 13, 2011, from <http://webapps.cihr-irsc.gc.ca/funding/

Search?p_language=E&p_version=CIHR>.

91. Rx&D, Rx&D Health Research Foundation, accessed on July 8, 2011, from

<https://www.canadapharma.org/en/difference/foundation/default.aspx>.

92. United States National Institutes of Health, ClinicalTrials.Gov, accessed on July 15, 2011,

92. United States National Institutes of Health, ClinicalTrials.Gov, accessed on July 15, 2011,